Results 91 to 100 of about 205,806 (279)
Generic bifurcations of low codimension of planar Filippov Systems
, 2011 In this article some qualitative and geometric aspects of non-smooth dynamical systems theory are discussed. The main aim of this article is to develop a systematic method for studying local (and global) bifurcations in non-smooth dynamical systems.
M. Guardia, T. M. Seara, M. Teixeira
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Dual Aptamers‐Based SETDB1 PROTACs as Effective Anti‐Tumor Strategies for Breast Cancer
Advanced Science, EarlyView.This study establishes dual‐aptamer PROTACs targeting SETDB1 using a SETDB1‐specific aptamer conjugated to AS1411. The designed PROTACs penetrate cells, recruit MDM2 to degrade SETDB1, and inhibit cancer cell proliferation and migration. Remarkably, they also overcome tamoxifen resistance and enhance CD8+ T cell cytotoxicity, suppressing tumor growth ...
Yanxuan Guo +6 more
wiley +1 more source
Advanced Science, EarlyView.This study is pioneering in constructing the shortest known synthetic pathway for L‐theanine production from xylose within E coli. Through comprehensive metabolic engineering strategies, our engineered strain achieved the highest reported L‐theanine titer from xylose, with a titer of 95.42 g/L, and a yield of 0.55 g/g.
Haolin Han +5 more
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Advanced Science, EarlyView.Autologous tumor‐infiltrating lymphocyte (TIL) therapy shows promising efficacy in acral melanoma, yet determinants of durable response remain unclear. By integrating single‐cell transcriptomics and TCR sequencing, this study reveals that TIL products enriched for T follicular helper and intermediate exhausted T cells establish persistent clonal ...
Chao Zhang +12 more
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Advanced Science, EarlyView.A biomimetic Prussian White nanoparticle (PW) is engineered to achieve long‐term local retention and orchestrate immunometabolic‐epigenetic remodeling for sciatic nerve regeneration. PW directly targets hexokinase 2 to suppress glycolysis, thereby elevating α‐ketoglutarate and driving Kdm4a/b‐mediated demethylation of H3K9me3.
Wenying Xu +6 more
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Refuge used by prey as a function of predator numbers in a Leslie-type model
Selecciones MatemáticasThis paper deals with a continuous-time predator-prey model of Leslie-Gower type considering the use of a physical refuge by a fraction of the prey population.
Paulo Tintinago-Ruiz +2 more
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Magneto‐X Effects in Magnetic Soft Materials and Their Applications
Advanced Science, EarlyView.This review systematically explores magnetic soft materials (MSMs), a novel class of composites that transform under magnetic fields. It catalogs fundamental “Magneto‐X” effects, classifies materials by their matrix and magnetic fillers, and highlights transformative applications in soft robotics, biomedical devices, flexible electronics, etc. Finally,
Ziyin Xiang +5 more
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Bifurcation and Chaos in a Nonlinear Population Model with Delayed Nonlinear Interactions
MathematicsThis paper investigates the dynamic behavior of a second-order nonlinear rational difference equation modeling a population system with nonlinear interactions between current and previous population states.
Bashir Al-Hdaibat, A. Alameer
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Advanced Science, EarlyView.The adsorption of AsV on akaganeite nanorods was found to provide a magnetic signature. A change in the surface spin order gave rise to a second peak in the zero‐field cooled curve. AsIII adsorption does not provide any change in the magnetic behavior of the sorbent.
Marco Sanna Angotzi +11 more
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Nonlinear Oscillations, Dynamical Systems, and Bifurcations of Vector Fields
Applied Mathematical Sciences, 1983 J. Guckenheimer, P. Holmes
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