Results 151 to 160 of about 589,491 (167)

Soman induces endoplasmic reticulum stress and apoptosis of cerebral organoids via the GRP78‐ATF6‐CHOP signaling pathway

open access: yesFEBS Open Bio, EarlyView.
Cerebral organoids were employed as a novel model to explore the neurotoxicity of soman. Soman inhibited acetylcholinesterase activity, increased cell apoptosis and upregulated endoplasmic reticulum (ER) stress markers glucose‐regulated protein 78 (GRP78), activating transcription factor 6 (ATF6) and C/EBP homologous protein (CHOP).
Yue Wei   +7 more
wiley   +1 more source

On subcellular distribution of the zinc finger 469 protein (ZNF469) and observed discrepancy in the localization of endogenous and overexpressed ZNF469

open access: yesFEBS Open Bio, EarlyView.
ZNF469 regulates the expression of genes encoding extracellular matrix proteins. Endogenous ZNF469 is predominantly cytoplasmic, while in transfected cells, it forms aggregates reminiscent of biomolecular condensates, located mainly in the nucleus. These condensates exhibit overlapping staining with proteasomes and are also associated with the mitotic ...
Anne Elisabeth Christensen Mellgren   +8 more
wiley   +1 more source

Enhanced discovery of bacterial laccase‐like multicopper oxidase through computer simulation and metagenomic analysis of industrial wastewater

open access: yesFEBS Open Bio, EarlyView.
We obtained potential bacterial laccase‐like multicopper oxidase (LMCO) sequences through metagenomic sequencing. All sequences exhibited significant differences from known LMCOs in databases. To select the most promising candidates, we performed structure prediction and molecular docking using alphafold2, metal3d and rosetta.
Ting Cui   +5 more
wiley   +1 more source

Protein O‐glycosylation in the Bacteroidota phylum

open access: yesFEBS Open Bio, EarlyView.
Species of the Bacteroidota phylum exhibit a unique O‐glycosylation system. It modifies noncytoplasmic proteins on a specific amino acid motif with a shared glycan core but a species‐specific outer glycan. A locus of multiple glycosyltransferases responsible for the synthesis of the outer glycan has been identified.
Lonneke Hoffmanns   +2 more
wiley   +1 more source

Big Questions for “Big Data”

Annals of Emergency Medicine, 2016
Annals of Emergency Medicine - In Press.Proof corrected by the author Available online since mardi 20 octobre ...
Deborah J. Williams   +2 more
openaire   +3 more sources

Big data, big picture

Veterinary Record, 2018
Ten years ago, a pilot project was launched from the University of Liverpool to explore whether it would be feasible to collect data from small animal veterinary practices and diagnostic laboratories. Surveillance data were well established on the farm side – through data collected by APHA and its previous guises, the SAC and AFBI.
openaire   +2 more sources

Big Data, Big Challenges

Ophthalmology, 2016
The relatively rapid and recent adoption of electronic health records (EHRs) in ophthalmology has been associated with the promise that the accumulation of large volumes of clinical data would facilitate quality improvement and help to answer a variety of research questions.
openaire   +3 more sources

Big business with Big Data Big Business mit Big Data

GIS Business, 2019
Big business with Big Data Big Business mit Big ...
openaire   +1 more source

Big data, big opportunities

Veterinary Record, 2016
The potential use of ‘big data’ in veterinary surveillance was highlighted by two speakers at the BVA Congress at the London Vet Show last month.
openaire   +2 more sources

Big Data Behind Big Data

2016
There is data related to the collection and management of big data that is as relevant as the primary datasets being collected, and can itself be very large. In this chapter, we will examine two aspects of High Performance Computing (HPC) data that fall under the category of big data.
Elizabeth Bautista   +2 more
openaire   +2 more sources

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