Results 151 to 160 of about 26,034,833 (395)
The role and implications of mammalian cellular circadian entrainment
FEBS Letters, EarlyView.At their most fundamental level, mammalian circadian rhythms occur inside every individual cell. To tell the correct time, cells must align (or ‘entrain’) their circadian rhythm to the external environment. In this review, we highlight how cells entrain to the major circadian cues of light, feeding and temperature, and the implications this has for our
Priya Crosby
wiley +1 more source
Peptide‐based ligand antagonists block a Vibrio cholerae adhesin
FEBS Letters, EarlyView.The structure of a peptide‐binding domain of the Vibrio cholerae adhesin FrhA was solved by X‐ray crystallography, revealing how the inhibitory peptide AGYTD binds tightly at its Ca2+‐coordinated pocket. Structure‐guided design incorporating D‐amino acids enhanced binding affinity, providing a foundation for developing anti‐adhesion therapeutics ...
Mingyu Wang +9 more
wiley +1 more source
Is big data a big deal? A competition law approach to big data [PDF]
, 2017 Greg Sivinski +2 more
openalex +1 more source
Proceedings of the ACM Eighteenth International Workshop on Data Warehousing and OLAP, 2015 It is widely accepted today that Relational databases are not appropriate in highly distributed shared-nothing archi- tectures of commodity hardware, that need to handle poorly structured heterogeneous data. This has brought the bloom- ing of NoSQL systems with the purpose of mitigating such problem, specially in the presence of analytical workloads ...
openaire +2 more sources
FEBS Letters, EarlyView.This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley +1 more source
Real‐time assay of ribonucleotide reductase activity with a fluorescent RNA aptamer
FEBS Letters, EarlyView.Ribonucleotide reductases (RNR) synthesize DNA building blocks de novo, making them crucial in DNA replication and drug targeting. FLARE introduces the first single‐tube real‐time coupled RNR assay, which enables isothermal tracking of RNR activity at nanomolar enzyme levels and allows the reconstruction of allosteric regulatory patterns and rapid ...
Jacopo De Capitani +4 more
wiley +1 more source
Big Data: Big Challenges, Big Opportunities: The Reification of Consilience [PDF]
, 2019 Reed, Daniel A.
core +2 more sources
Big Data, Sentiment Analysis, and Examples during the COVID-19 Pandemic
, 2022 Kyvele Constantina Diareme +2 more
openalex +2 more sources
Business Intelligence and Analytics: From Big Data to Big Impact
MIS Q., 2012 Hsinchun Chen +2 more
semanticscholar +1 more source