Results 151 to 160 of about 24,640,092 (292)

The promise of big data: don't fence me in. [PDF]

World Psychiatry
Vigo D.
europepmc   +1 more source

A context‐dependent modulatory role for eIF6 in acquired resistance to vemurafenib in melanoma

FEBS Letters, EarlyView.
Acquired resistance to vemurafenib upregulates the translation factor eIF6 in melanoma cells. Silencing eIF6 in resistant cells reduces proliferation and partially restores drug sensitivity, whereas its overexpression increases sensitivity across melanoma lines regardless of BRAF status, via modulation of mTOR, S6K, and MAPK signaling.
George Kyriakopoulos, Antonia Petropoulou, Alexandra Anastogianni, Angelina Bania, Vassilis Stamatakis, Argyris Alexiou, Chi‐Ping Day, Glenn Merlino, Katerina Grafanaki, Constantinos Stathopoulos   +9 more
wiley   +1 more source

Thicket of Diversity Pamphlet

, 2000
Fundraising pamphlet for the Big Thicket Association's "Thicket of Diversity" All Taxa Biodiversity Inventory of Big Thicket National Preserve ...
Big Thicket Association
core  

Big data, disease mechanisms and clinically actionable discovery. [PDF]

World Psychiatry
McIntosh A.
europepmc   +1 more source

Metastatic niche shaped by host factors influences disseminated cancer cell fate

FEBS Letters, EarlyView.
Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward, Álvaro Ruiz‐Tabas, Patricia Altea‐Manzano   +2 more
wiley   +1 more source

Big Bear bakey photo

, 1962
Black and white photo of a Big Bear bakery, featured in the Grocers Beacon, Special Edition on Big Bear. Big Bear Bakeries, Inc. ("Bakery") owned and operated a central bakery in Columbus and manufactured and distributed fresh bread and pastery products ...
Big Bear
core  

Big data research: the importance of the data-generating process and domain expertise. [PDF]

World Psychiatry
Smoller JW.
europepmc   +1 more source

Invisible but not inaccessible—Revealing transient oligomers formed by intrinsically disordered proteins with solution NMR and complementary methods

FEBS Letters, EarlyView.
Transient oligomers formed by intrinsically disordered proteins may be ‘invisible’ to direct detection yet remain accessible to solution NMR through equilibrium‐exchange measurements and pressure‐jump experiments. Complementary methods report on mass, stoichiometry, selected distance distributions, morphology, and internal packing.
Martin D. Gelenter, Ad Bax
wiley   +1 more source

Big data and psychiatry: advances, constraints and future directions. [PDF]

World Psychiatry
Stein DJ, Kessler RC, Torous J, Garavan H, van den Heuvel OA, Derks EM, Mathews C, Cuijpers P, Salum GA, Andreassen OA, Thompson PM, Penninx BWJ, McGrath JJ.   +12 more
europepmc   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source