Results 201 to 210 of about 3,103,465 (226)

Soman induces endoplasmic reticulum stress and apoptosis of cerebral organoids via the GRP78‐ATF6‐CHOP signaling pathway

FEBS Open Bio, EarlyView.
Cerebral organoids were employed as a novel model to explore the neurotoxicity of soman. Soman inhibited acetylcholinesterase activity, increased cell apoptosis and upregulated endoplasmic reticulum (ER) stress markers glucose‐regulated protein 78 (GRP78), activating transcription factor 6 (ATF6) and C/EBP homologous protein (CHOP).
Yue Wei, Zhanbiao Liu, Jingjing Shi, Qian Jin, Wenqian Chen, Xuejun Chen, Liqin Li, Hui Chen   +7 more
wiley   +1 more source

A psycho-behavioral perspective research for elderly leisure sports participation via big-data and comparative analyses. [PDF]

BMC Psychol
Choi C, Park SU, Kim DK.
europepmc   +1 more source

On subcellular distribution of the zinc finger 469 protein (ZNF469) and observed discrepancy in the localization of endogenous and overexpressed ZNF469

FEBS Open Bio, EarlyView.
ZNF469 regulates the expression of genes encoding extracellular matrix proteins. Endogenous ZNF469 is predominantly cytoplasmic, while in transfected cells, it forms aggregates reminiscent of biomolecular condensates, located mainly in the nucleus. These condensates exhibit overlapping staining with proteasomes and are also associated with the mitotic ...
Anne Elisabeth Christensen Mellgren, Ileana Cristea, Thomas Stevenson, Endy Spriet, Per Morten Knappskog, Stig Ove Bøe, Harald Kranz, Sushma N. Grellscheid, Eyvind Rødahl   +8 more
wiley   +1 more source

Large Language Model-Based Critical Care Big Data Deployment and Extraction: Descriptive Analysis.

JMIR Med Inform
Yang Z, Xu SS, Liu X, Xu N, Chen Y, Wang S, Miao MY, Hou M, Liu S, Zhou YM, Zhou JX, Zhang L.   +11 more
europepmc   +1 more source

A big data analysis algorithm for massive sensor medical images. [PDF]

PeerJ Comput Sci
Alzakari SA, Alruwais N, Sorour S, Ebad SA, Hassan Elnour AA, Sayed A.   +5 more
europepmc   +1 more source

Enhanced discovery of bacterial laccase‐like multicopper oxidase through computer simulation and metagenomic analysis of industrial wastewater

FEBS Open Bio, EarlyView.
We obtained potential bacterial laccase‐like multicopper oxidase (LMCO) sequences through metagenomic sequencing. All sequences exhibited significant differences from known LMCOs in databases. To select the most promising candidates, we performed structure prediction and molecular docking using alphafold2, metal3d and rosetta.
Ting Cui, Ariel Kushmaro, Hana Barak, Anja Poehlein, Rolf Daniel, Hans‐Jürgen Mägert   +5 more
wiley   +1 more source

Big-data empowered traffic signal control could reduce urban carbon emission. [PDF]

Nat Commun
Wu K, Ding J, Lin J, Zheng G, Sun Y, Fang J, Xu T, Zhu Y, Gu B.   +8 more
europepmc   +1 more source

Pharmacogenomics and Big Data in medical oncology: developments and challenges. [PDF]

Ther Adv Med Oncol
Marcu LG, Marcu DC.
europepmc   +1 more source

Big Data-Driven Evolution of a Diagnostic Multiplex IgE-Test: Enhancing Accuracy and Efficacy in Allergy Diagnostics. [PDF]

Int J Mol Sci
Lupinek C, Forstenlechner P, Ringauf A, Campana R, Salihu A, Aumayr M, Mittermann I.   +6 more
europepmc   +1 more source

Planning and layout of tourism and leisure facilities based on POI big data and machine learning. [PDF]

PLoS One
Wu S, Wang J, Jia Y, Yang J, Li J.
europepmc   +1 more source