Homologous expression and purification of human HAX‐1 for structural studies
FEBS Open Bio, EarlyView.This research protocol provides detailed instructions for cloning, expressing, and purifying large quantities of the intrinsically disordered human HAX‐1 protein, N‐terminally fused to a cleavable superfolder GFP, from mammalian cells. HAX‐1 is predicted to undergo posttranslational modifications and to interact with membranes, various cellular ...
Mariana Grieben
wiley +1 more source
Public and Patient Involvement in Artificial Intelligence and Big Data Healthcare Research: An Exploration of Issues and Challenges Within the AI-Multiply Project. [PDF]
Health ExpectThompson A +6 more
europepmc +1 more source
Extracting Market Value of Business and Business Decision from Big Data Analytics
, 2016 Sarswati Kumar
openalex +1 more source
Thrombolytic proteins profiling: High‐throughput activity, selectivity, and resistance assays
FEBS Open Bio, EarlyView.We present optimized biochemical protocols for evaluating thrombolytic proteins, enabling rapid and robust screening of enzymatic activity, inhibition resistance, and fibrin affinity, stimulation, and selectivity. The outcome translates to key clinical indicators such as biological half‐life and bleeding risk. These assays streamline the development of
Martin Toul +3 more
wiley +1 more source
Biomedical Big Data and Artificial Intelligence in Blood. [PDF]
Genomics Proteomics BioinformaticsHe F, Zhang Z, Fang X, Wang QF.
europepmc +1 more source
The Significance Of Big Data For The Base Of The Pyramid Segment
, 2018 Keerthan Raj, P. S. Aithal
openalex +2 more sources
Overview of molecular signatures of senescence and associated resources: pros and cons
FEBS Open Bio, EarlyView.Cells can enter a stress response state termed cellular senescence that is involved in various diseases and aging. Detecting these cells is challenging due to the lack of universal biomarkers. This review presents the current state of senescence identification, from biomarkers to molecular signatures, compares tools and approaches, and highlights ...
Orestis A. Ntintas +6 more
wiley +1 more source
RETRACTION: Evaluation of Ecological Water Consumption in Yanhe River Basin Based on Big Data. [PDF]
Comput Intell NeurosciNeuroscience CIA.
europepmc +1 more source
APPROACHES OF BIG DATA IN HEALTHCARE: A CRITICAL REVIEW
, 2018 Faizan Ahmad, Manish Madhava Tripathi
openalex +2 more sources
Molecular determinants of signal transduction in tropomyosin receptor kinases
FEBS Open Bio, EarlyView.Tropomyosin receptor kinases control critical neuronal functions, but how do the same receptors produce diverse cellular responses? This review explores the structural mechanisms behind Trk signaling diversity, focusing on allosteric modulation and ligand bias.
Giray Enkavi
wiley +1 more source