Results 311 to 320 of about 26,034,833 (395)

LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro

Molecular Oncology, EarlyView.
Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix, Daniel Samaga, Katharina Gehr, Benedek Dankó, Mohamed Schumann, Guido Drexler, Ahmed Alnatsha, Georg Beyer, Ujjwal Mahajan, Martin Selmansberger, Julia Mayerle, Claus Belka, Horst Zitzelsberger, Kirsten Lauber   +13 more
wiley   +1 more source

Analysis of the distribution of health services in the State of São Paulo: focus on Big Data. [PDF]

Einstein (Sao Paulo)
Marques MA, Maximiano CFC, Martins TGDS, Nascimento AVD.   +3 more
europepmc   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

The future of big data and artificial intelligence on dairy farms: A proposed dairy data ecosystem. [PDF]

JDS Commun
Hostens M, Franceschini S, van Leerdam M, Yang H, Pokharel S, Liu E, Niu P, Zhang H, Noor S, Hermans K, Salamone M, Sharma S.   +11 more
europepmc   +1 more source

Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition

Molecular Oncology, EarlyView.
We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li, Shuichi Tatarano, Hirofumi Yoshino, Saeki Saito, Mitsuhiko Tominaga, Junya Arima, Ikumi Fukuda, Takashi Sakaguchi, Ryosuke Matsushita, Yasutoshi Yamada, Hideki Enokida   +10 more
wiley   +1 more source

Turning data into insights in Jub, an extensible generic big data platform for life science and healthcare applications. [PDF]

Sci Rep
Castillo-Barrios I, Crespo-Sanchez M, Reyes-Anastacio HG, Gonzalez-Compean JL, Lopez-Arevalo I, Barron-Lugo JA, Morin-Garcia JC, Leal YA, Calderon-Hernandez J, Aguirre-Meneses H, Núñez-Gaona MA.   +10 more
europepmc   +1 more source

Infrared laser sampling of low volumes combined with shotgun lipidomics reveals lipid markers in palatine tonsil carcinoma

Molecular Oncology, EarlyView.
Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff, Manuela Moritz, Dennis Eggert, Anna Worthmann, Joerg Heeren, Henrike Zech, Till S. Clauditz, Waldemar Wilczak, Hartmut Schlüter, Christian S. Betz, Arne Böttcher, Jan Hahn   +11 more
wiley   +1 more source

Opportunities for RNA sequencing in physiology: from big data to understanding homeostasis and heterogeneity. [PDF]

Function (Oxf)
Prokop JW, Bilinovich SM, Tokarski E, Vishweswaraiah S, VanderWeele S, Das AS, Chhetri SB, Dao A, Arora S, Goodyke A, Buelow KL, Westgate M, VanSickle EA, Edell CJ, Benson LN, Campbell DB, Bupp CP, Holsworth A, Hartog NL, Krueger JM, Cordoba M, Sims M, Tamae Kakazu MA, Peraino AM, Graham SF, Triche T, Hussain E, Leimanis-Laurens ML, Krawczyk CM, Pollock JS, Rajasekaran S.   +30 more
europepmc   +1 more source

Cyber Security: Big Data Think II Working Group Meeting

, 2015
Thomas H. Hinke, Derek Shaw
openalex   +1 more source

Crucial parameters for precise copy number variation detection in formalin‐fixed paraffin‐embedded solid cancer samples

Molecular Oncology, EarlyView.
This study shows that copy number variations (CNVs) can be reliably detected in formalin‐fixed paraffin‐embedded (FFPE) solid cancer samples using ultra‐low‐pass whole‐genome sequencing, provided that key (pre)‐analytical parameters are optimized.
Hanne Goris, Vasiliki Siozopoulou, Léon C van Kempen, Anne Sieben, Ella Roelant, Stig Hellemans, Elyne Backx, Laure Sorber, Koen De Winne, Senada Koljenović, Karen Zwaenepoel   +10 more
wiley   +1 more source