Results 321 to 330 of about 26,034,833 (395)

Korea's Bio Big Data Project: Importance and Challenges of Governance and Data Utilization. [PDF]

Healthc Inform Res
Kim JS, Hong DU.
europepmc   +1 more source

Phenotypic and genotypic characterization of single circulating tumor cells in the follow‐up of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon, Rui P. L. Neves, Nikolas H. Stoecklein, Sven‐Thorsten Liffers, Jens Siveke, Jan D. Kuhlmann, Pauline Wimberger, Paul Buderath, Rainer Kimmig, Sabine Kasimir‐Bauer   +9 more
wiley   +1 more source

Small Bugs, Big Data: Metagenomics for Arthropod Biodiversity Monitoring. [PDF]

Ecol Evol
López Clinton S, Iwaszkiewicz-Eggebrecht E, Miraldo A, Goodsell R, Webster MT, Ronquist F, van der Valk T.   +6 more
europepmc   +1 more source

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

Molecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang, Dong Jun Koo, Peter M. Tessier, Greg M. Thurber   +3 more
wiley   +1 more source

The institutional responses to new plant variety protection in China in the context of big data. [PDF]

Front Plant Sci
Yu F, Liu X.
europepmc   +1 more source

Tumor mutational burden as a determinant of metastatic dissemination patterns

Molecular Oncology, EarlyView.
This study performed a comprehensive analysis of genomic data to elucidate whether metastasis in certain organs share genetic characteristics regardless of cancer type. No robust mutational patterns were identified across different metastatic locations and cancer types.
Eduardo Candeal, Andrea Moreno‐Manuel, Miguel Salvadó‐Pertierra, Cristina Santos‐Vivas, Rebeca Sanz‐Pamplona   +4 more
wiley   +1 more source

Correction: NanoBERTa-ASP: predicting nanobody paratope based on a pretrained RoBERTa model

BMC Bioinformatics
Shangru Li, Xiangpeng Meng, Rui Li, Bingding Huang, Xin Wang   +4 more
doaj   +1 more source

The analysis of the internet of things technology for mental health of sports education students based on big data. [PDF]

Sci Rep
He Y.
europepmc   +1 more source

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

Molecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli, Alessio Bevilacqua, Mathias Wenes, Denis Migliorini, Lars van der Veen, Sigrid S Skånland, Giusy Di Conza, Kjetil Taskén   +7 more
wiley   +1 more source

Development of data-driven clinical pathways: the big data clinical evidence-based pathways. [PDF]

BMJ Health Care Inform
Cui X, Sui M, Xie H, Chen W, Tian W, Wang P, Jiang X, Fu C, Xu S.   +8 more
europepmc   +1 more source