Results 331 to 340 of about 25,420,692 (388)

Polydatin ameliorates ovalbumin‐induced asthma in a rat model through NCOA4‐mediated ferroautophagy and ferroptosis pathway

FEBS Open Bio, EarlyView.
In this research, a rat model of asthma was created using OVA, and polydatin served as an intervention. By inhibiting ferroautophagy mediated by NCOA4 and averting ferroptosis, polydatin has been demonstrated to reduce asthma. This work presents new ideas for investigating the mechanism of polydatin's ability to alleviate asthma, in addition to ...
Wei Li, Yuwei Tang, Wenkang Liu, Fang Fang, Jiepeng Wang, Chaoyi Fang   +5 more
wiley   +1 more source

Empirical evidence and role mechanisms of big data enabling corporate green development. [PDF]

Sci Rep
Wang Y, Li Y, Ruan Z, Tang Z, Gao T.
europepmc   +1 more source

Blocking the voltage‐gated sodium channel hNav1.5 as a novel pH‐dependent mechanism of action for tamoxifen

FEBS Open Bio, EarlyView.
Patch‐clamp recordings revealed that tamoxifen inhibits voltage‐gated sodium channels, especially under acidic conditions, both common in metastatic cancer cells. These effects may explain certain antitumor properties of tamoxifen, highlighting a novel mechanism of action beyond its known endocrine effects.
Karl Josef Föhr, Michael Fauler, Thomas Zimmer, Bettina Jungwirth, Hubert Schrezenmeier, David Alexander Christian Messerer   +5 more
wiley   +1 more source

Big Data Analytics for Uncovering Voxel Connectivity Patterns in Attention Deficit Hyperactivity Disorder. [PDF]

J Multidiscip Healthc
Caraka RE, Supardi K, Gio PU, Isnaniawardhani V, Chen RC, Djatmiko B, Pardamean B.   +6 more
europepmc   +1 more source

High LRIG1 expression predicts lymph node metastasis in patients with uterine cervical cancer

FEBS Open Bio, EarlyView.
Lymph node status is crucial in determining treatment for women with early‐stage cervical cancer. We demonstrate that high LRIG1 protein expression in primary tumors can predict lymph node metastases. Our findings support further investigation of LRIG1 as a biomarker to improve staging accuracy and guide treatment decisions in cervical cancer patients.
Pernilla Israelsson, Lisa Lif, Husam Oda, Alexandra Lorenzzi de Melo, David Lindquist, Håkan Hedman   +5 more
wiley   +1 more source

A guide to reverse metabolomics-a framework for big data discovery strategy. [PDF]

Nat Protoc
Charron-Lamoureux V, Mannochio-Russo H, Lamichhane S, Xing S, Patan A, Portal Gomes PW, Rajkumar P, Deleray V, Caraballo-Rodríguez AM, Chua KV, Lee LS, Liu Z, Ching J, Wang M, Dorrestein PC.   +14 more
europepmc   +1 more source

Spatial heterogeneity of built environment's impact on urban vitality using multi-source big data and MGWR. [PDF]

Sci Rep
Wu W, Liu X, Zhou Y, Zhao K.
europepmc   +1 more source

The Big Data Era in Cardiology and Cardiovascular Medicine: Advanced Analytics for Truly Personalized Care. [PDF]

Diagnostics (Basel)
Ambrosino P, Manzo F, Candia C, Spedicato GA, Grassi G, Maniscalco M.   +5 more
europepmc   +1 more source

Big-Data Analysis of Geometric Descriptors as Efficient Predictors of Energetic Stability in Nonplanar Polycyclic Aromatic Hydrocarbons. [PDF]

J Comput Chem
Gregory KP, Karton A.
europepmc   +1 more source

RETRACTION: Challenges and Opportunities of Big Data Analytics in Healthcare. [PDF]

Health Care Sci
europepmc   +1 more source