Results 61 to 70 of about 3,434,319 (342)

Making tau amyloid models in vitro: a crucial and underestimated challenge

FEBS Letters, EarlyView.
This review highlights the challenges of producing in vitro amyloid assemblies of the tau protein. We review how accurately the existing protocols mimic tau deposits found in the brain of patients affected with tauopathies. We discuss the important properties that should be considered when forming amyloids and the benchmarks that should be used to ...
Julien Broc, Clara Piersson, Yann Fichou
wiley   +1 more source

A high temporal resolution global gridded dataset of human thermal stress metrics

Scientific Data
The human thermal stress indices and datasets are vital for promoting public health and reducing negative environmental impacts as global climate change and extreme meteorological events increase.
Hongdeng Jian, Zhenzhen Yan, Xiangtao Fan, Qin Zhan, Chen Xu, Weijia Bei, Jianhao Xu, Mingrui Huang, Xiaoping Du, Junjie Zhu, Zhimin Tai, Jiangtao Hao, Yanan Hu   +12 more
doaj   +1 more source

Impact of Biases in Big Data [PDF]

, 2018
The underlying paradigm of big data-driven machine learning reflects the desire of deriving better conclusions from simply analyzing more data, without the necessity of looking at theory and models. Is having simply more data always helpful? In 1936, The
Glauner, Patrick, State, Radu, Valtchev, Petko   +2 more
core   +1 more source

Clustering Big Data

Proceedings of the 7th International Conference on Data Science, Technology and Applications, 2018
abstract
Michele Ianni, Elio Masciari, Giuseppe M. Mazzeo, Carlo Zaniolo   +3 more
openaire   +6 more sources

Interaction vesicles as emerging mediators of host‐pathogen molecular crosstalk and their implications for infection dynamics

FEBS Letters, EarlyView.
Interaction extracellular vesicles (iEVs) are hybrid vesicles formed through host‐pathogen communication. They facilitate immune evasion, transfer pathogens' molecules, increase host cell uptake, and enhance virulence. This Perspective article illustrates the multifunctional roles of iEVs and highlights their emerging relevance in infection dynamics ...
Bruna Sabatke, Izadora Volpato Rossi, Marcel I. Ramirez   +2 more
wiley   +1 more source

Deconstructability prediction for building using machine learning and ensemble feature selection techniques

Scientific Reports
Construction industries remain one of the most significant users of materials and generators of waste in the UK and globally. Notwithstanding, the principle of circular economy is becoming prominent as an effective means for powering greater resource ...
Habeeb Balogun, Hafiz Alaka, Eren Demir, Christian Nnaemeka Egwim, Godoyon Ebenezer Wusu, Wasiu Yusuf, Muideen Adegoke, Iqbal Qasim   +7 more
doaj   +1 more source

The Prediction of Multistep Traffic Flow Based on AST-GCN-LSTM

Journal of Advanced Transportation, 2021
Aiming at the traffic flow prediction problem of the traffic network, this paper proposes a multistep traffic flow prediction model based on attention-based spatial-temporal-graph neural network-long short-term memory neural network (AST-GCN-LSTM).
Fan Hou, Yue Zhang, Xinli Fu, Lele Jiao, Wen Zheng   +4 more
doaj   +1 more source

Managing Research Data in Big Science [PDF]

, 2012
The project which led to this report was funded by JISC in 2010--2011 as part of its 'Managing Research Data' programme, to examine the way in which Big Science data is managed, and produce any recommendations which may be appropriate.
Carozzi, Tobia, Gray, Norman, Woan, Graham   +2 more
core   +1 more source

B cell mechanobiology in health and disease: emerging techniques and insights into therapeutic responses

FEBS Letters, EarlyView.
B cells sense external mechanical forces and convert them into biochemical signals through mechanotransduction. Understanding how malignant B cells respond to physical stimuli represents a groundbreaking area of research. This review examines the key mechano‐related molecules and pathways in B lymphocytes, highlights the most relevant techniques to ...
Marta Sampietro, Marco Cellani, Cristina Scielzo   +2 more
wiley   +1 more source

Disruption of SETD3‐mediated histidine‐73 methylation by the BWCFF‐associated β‐actin G74S mutation

FEBS Letters, EarlyView.
The β‐actin G74S mutation causes altered interaction of actin with SETD3, reducing histidine‐73 methylation efficiency and forming two distinct actin variants. The variable ratio of these variants across cell types and developmental stages contributes to tissue‐specific phenotypical changes. This imbalance may impair actin dynamics and mechanosensitive
Anja Marquardt, Marcus S. Münchhoff, Jacqueline Krohn, Philip M. Palarz, Manuel H. Taft, Johannes N. Greve, Nataliya Di Donato, Falk F. R. Buettner, Dietmar J. Manstein   +8 more
wiley   +1 more source