Results 201 to 210 of about 951,209 (293)

Aspirin‐Derived Salicyl‐CoA Drives Histone Lysine Salicylation Regulated by CBP and SIRT2

Advanced Science, EarlyView.
Aspirin‐derived salicyl‐CoA serves as a previously unrecognized acyl donor for protein lysine salicylation. This study identifies histone lysine salicylation as a reversible epigenetic modification regulated by CBP and SIRT2, expanding the biochemical actions of aspirin beyond its canonical acetylation‐dependent mechanisms and providing a new framework
Facai Zhang, Chuanzan Zhou, Jiaoyan He, Pengpeng Huang, Rong Zhang, Huan Hu, Meng Jiao, Linyi Hu, Feng Liu, Xiaolong Qi, Xiang He, Yunkai Yang, Y Eugene Chinn, Dechao Feng, Dahong Zhang, Qi Zhang   +15 more
wiley   +1 more source

Commercial Translation of Electrochemical Biosensors: Supply Chain Strategy, Scale-Up Manufacturing, and Regulatory-Quality Considerations. [PDF]

Biosensors (Basel)
Zhou G, Liu H.
europepmc   +1 more source

Modulation of the TGF‐β/Smad Signaling Pathway by a Bioactive Oxidized Polygonati Rhizoma Polysaccharide Crosslinked Chitosan Hydrogel as Therapeutic Carrier for Parkinson's Disease Treatment

Advanced Science, EarlyView.
An injectable, self‐healing COPRP hydrogel integrates structurally defined oxidized Polygonati rhizoma polysaccharide with carboxymethyl chitosan through dynamic Schiff‐base crosslinking. The bioactive matrix scavenges reactive oxygen species, suppresses neuroinflammation, protects dopaminergic neurons, and supports sustained levodopa release.
Peng Dai, Jikuang Zhao, Chang Xue, Kailei Xu, Liang Yong, Zhuangwei Zhang, Yi Huang, Jianwei Shuai, Xianzhen Chen, Sheng Nie, Junpeng Xu   +10 more
wiley   +1 more source

Therapeutic value in the time of digital brainwaves. [PDF]

Soc Stud Sci
Marathe M.
europepmc   +1 more source

Thickness‐Gradient Liquid Metal Connectors for Seamless Electrophysiological Sensors

Advanced Science, EarlyView.
Thickness‐gradient liquid metal interfaces with elastomeric substrates enable seamless integration between ultrathin skin‐conformal electrodes and external interconnects. The mechanically compliant connector reduces interfacial mismatch and supports stable ECG/EMG monitoring under bending and motion.
Jinyoung Kim, Jaejun Lee, Christopher E. Tabor, Vladimir V. Tsukruk   +3 more
wiley   +1 more source

In their own words: qualitative interviews with veterinarians on handling decisions during dog examinations. [PDF]

Front Vet Sci
Nakonechny L, Schroeder K, Stellato AC.
europepmc   +1 more source

TROP2‐Targeting Chimeras (TRTACs) for Tumor Cell‐Selective Membrane Protein Degradation and Enhanced Drug Delivery

Advanced Science, EarlyView.
TROP2 is identified as a novel tumor‐selective lysosomal‐targeting receptor with established clinical relevance. TROP2‐targeting chimeras (TRTACs) are developed by genetically fusing a TROP2‐binding nanobody to nanobodies against specific target proteins.
Luping Chen, Xinying Fu, Wenqian Dong, Xiaobei Deng, Simin Chen, Fujun Wang, Jian Zhao, Shiqun Shao, Liqiang Fan, Jingyu Zhang, Lixin Zhang   +10 more
wiley   +1 more source

Underserved and overburdened: an ethnographic examination of rural animal sheltering. [PDF]

Front Vet Sci
Bray LA, Jervis LL.
europepmc   +1 more source

Tailoring Electronic Structure of NbB2 Nanorods Through Selenium Incorporation for Synergistically Enhanced Hydrogen Evolution and Triboelectric Energy Harvesting

Advanced Science, EarlyView.
Selenium incorporation modulates the electronic structure of niobium diboride (Se‐NbB2) nanorods, enhancing the active site density and resulting in superior hydrogen evolution performance for sustainable energy applications. ABSTRACT The sluggish hydrogen evolution reaction (HER) kinetics of non‐noble‐metal catalysts remain a major challenge for ...
Shalmali R Burse, Vikram Mahamiya, Ali Mohammadi, Swapnil R Patil, Harshitha B Tyagaraj, Gagankumar S K, Amal AlGhafri, Ebrahim Al Hajri, Nilesh R. Chodankar, Yun Suk Huh, Young‐Kyu Han   +10 more
wiley   +1 more source