Advanced Science, EarlyView.A novel PLGA/PBAE polymer microparticle platform revolutionizes intermediate‐stage liver cancer treatment by co‐delivering panobinostat and IL‐12 via a single TACE‐like injection. This sustained‐release system overcomes tumor immunosuppression, triggers robust innate and adaptive immune responses, and establishes tertiary lymphoid structures ...
Hongzhe Yu +7 more
wiley +1 more source
Advanced Science, EarlyView.This bioinspired acinus‐on‐a‐chip recapitulates VILI pathology, revealing that volutrauma drives P53/NF‐κB pathways while barotrauma triggers mitochondrial‐Wnt dysregulation. A fibrotic transitional cell cluster was identified. Pharmacological interventions targeting these pathways significantly ameliorated injury, establishing a mechanobiological ...
Heng Lu +10 more
wiley +1 more source
Experiences across a genetic screening and testing programme pathway: a qualitative study of mammogram patient perspectives. [PDF]
BMJ OpenDevine C +5 more
europepmc +1 more source
China's Low‐Carbon Energy Transition Over the Past Two Decades: Experiences and Implications
Advanced Science, EarlyView.China's low‐carbon energy transition features a brief decline and subsequent rebound in coal consumption, alongside the rapid expansion of renewable energy. This study develops a stage‐based analytical framework to explain this evolution from the perspectives of economic development, energy security, and environmental sustainability, revealing how ...
Yu Liu +3 more
wiley +1 more source
Exploring the Dynamics of Attracting and Retaining Acute Care Psychiatric Registered Nurses: An In-Depth Analysis Using Focus Groups. [PDF]
J Nurs ManagRatnapradipa KL +10 more
europepmc +1 more source
OsCPK12‐OsATPD1 Module Regulates Photosynthetic Acclimation to Light Stress in Rice
Advanced Science, EarlyView.OsCPK12 interacts and phosphorylates OsAtpD1 at Ser8 in its transit peptide. This phosphorylation promote its chloroplast translocation, thereby maintaining ATP synthase activity and proton gradient (ΔpH) homeostasis and regulating photosynthetic acclimation, photoprotection, and repair under light stress.
Beifang Wang +17 more
wiley +1 more source
Toolkit to Promote Collaboration Between Surgeons and Anesthesiologists: Addressing Common Barriers to Perioperative Teamwork. [PDF]
J Am Coll SurgWei HS +12 more
europepmc +1 more source
Advanced Science, EarlyView.An integrative review of microfluidics‐enabled wearables and implantable systems reveals a single‐track translation pipeline, bridging functional biomaterials with clinical utility. Dynamic feedback loops driven by artificial intelligence advance diagnostics toward personalized closed‐loop theranostics.
Ke Huang +3 more
wiley +1 more source
Exploring the Motivations and the Concerns Behind Self-Managed Medication Abortion Done by Purchasing Medication Online: Qualitative Interview Study With US Abortion Seekers Post-Roe. [PDF]
J Med Internet ResBosco C, Otenen E, Shih PC.
europepmc +1 more source
As Big Tech corporations like Microsoft, Amazon, Meta, Apple, and Alphabet wield growing influence over society, concerns about their accountability remain unresolved. Their transnational operations, financial power, and lobbying efforts have outpaced regulatory mechanisms, creating an accountability gap. This dissertation investigates the role of news
openaire +1 more source