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Effect of biguanides and atromid on fibrinolysis
Journal of Atherosclerosis Research, 1967Summary The effects of phenformin, metformin, and Atromid on blood fibrinolytic activity, plasma fibrinogen, and serum cholesterol levels were compared in a study of 36 out-patients with occlusive vascular disease. Atromid was the least satisfactory fibrinolytic drug, having only a transient effect on the blood clot lysis time, though a more ...
Elizabeth D. Hocking +3 more
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Review of Biguanide (Metformin) Toxicity
Journal of Intensive Care Medicine, 2018In the 1920s, guanidine, the active component of Galega officinalis, was shown to lower glucose levels and used to synthesize several antidiabetic compounds. Metformin (1,1 dimethylbiguanide) is the most well-known and currently the only marketed biguanide in the United States, United Kingdom, Canada, and Australia for the treatment of non-insulin ...
Christopher Hoyte +3 more
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Biguanid-induzierte Laktatazidose
1995Es gibt Angaben, das das Risiko einer Laktatazidose unter Metformintherapie bei 0,024-0,084 Fallen pro 1000 Patientenjahre lage. Das entspricht 1:11000 bis 1:40 000 der Metformin-behandelten Patienten pro Jahr. Die Mortalitat ist nochmal um den Faktor 3 geringer. Die beschriebenen Todesfalle traten bei Patienten mit Kontraindikationen fur Metformin auf.
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CHAPTER 17:Antidiabetic Biguanides as Anti-Aging Drugs
, 2017Evidence has emerged that metformin and other antidiabetic biguabides are promising candidates for pharmacological interventions leading to slowing down of aging, prolonged life span and preventing or postponing age-associate diseases, including cancer ...
V. Anisimov
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Journal of the Chemical Society A: Inorganic, Physical, Theoretical, 1969
A series of quadricovalent cationic complexes of silver(III) with biguanide and with methylbiguanide having the composition [AgIIIL2]X3, where L is a bidentate ligand and X a univalent anion, has been prepared and characterised. In alkaline, neutral, and feebly acidic medium (pH > 5), the biguanide molecule possesses filled π-type delocalised orbitals.
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A series of quadricovalent cationic complexes of silver(III) with biguanide and with methylbiguanide having the composition [AgIIIL2]X3, where L is a bidentate ligand and X a univalent anion, has been prepared and characterised. In alkaline, neutral, and feebly acidic medium (pH > 5), the biguanide molecule possesses filled π-type delocalised orbitals.
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Environmental Fate of Polyhexamethylene Biguanide
Bulletin of Environmental Contamination and Toxicology, 2011Polyhexamethylene biguanide (PHMB) is used as a bacteriocidal agent in a variety of applications from medical devices to pools, but is highly toxic to some aquatic species. The stability of PHMB in various environmental matrices was examined. 80% of PHMB was present in fortified creek samples after 20 days, but bound immediately to soils with the ...
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Clinical Pharmacology of Biguanides
1996The biguanide drugs have been used to treat hyperglycaemia in non-insulin-dependent diabetes mellitus (NIDDM) for almost 40 years (Sterne 1969; Hermann 1979; Schafer 1983; Bailey 1992). Repeated reports of phenformin-associated lactic acidosis led to the withdrawal of this biguanide in the United States in 1977 and in most other countries.
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FIBRINOLYTIC EFFECT OF BIGUANIDES
Annals of the New York Academy of Sciences, 1968R. Chakrabarti +3 more
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