Results 61 to 70 of about 1,160,758 (288)

The effects of the entries by bike-sharing platforms on urban air quality

China Economic Quarterly International, 2023
We study the effects of bike-sharing usage on urban air quality in China. Our Difference-in-Differences strategy exploits the staggered entries by two leading bike-sharing companies, ofo and Mobike, and utilizes city-day panel data.
Guangyu Cao, Li-An Zhou, Chang Liu, Jingxin Zhou   +3 more
doaj   +1 more source

Shifting Gears: Framing Bike-sharing Trends in Sun Belt Cities

, 2015
As planners, policymakers and program operators throughout the country develop bike-share systems, they can benefit from a richer understanding of how people use bike-share programs in lower-density, automobile-oriented urban environments.
Walker, Kelsey, Shelton, Kyle
core   +1 more source

TRIM28‐Derived Peptide Exerts Anti‐Tumor Roles by Stabilizing Tumor Suppressive BRD7 Protein in Multiple Cancers

Advanced Science, EarlyView.
An α‐helical peptide, TAB12, designed to mimic the TRIM28 binding interface, competitively disrupts the TRIM28‐BRD7 interaction, thereby blocking ubiquitin‐mediated degradation of the tumor suppressor BRD7. This stabilization unleashes potent anti‐tumor effects across multiple tumor types with a favorable safety profile, offering a feasible strategy ...
Qingqing Wei, Changning Xue, Mengna Li, Jianxia Wei, Lemei Zheng, Shipeng Chen, Yijie Wang, Yumei Duan, Yanwei Luo, Wei Xiong, Ming Zhou   +10 more
wiley   +1 more source

SOLUTION TO FLEET SIZE OF DOCKLESS BIKE-SHARING STATION BASED ON MATRIX ANALYSIS [PDF]

ISPRS Annals of the Photogrammetry, Remote Sensing and Spatial Information Sciences, 2018
Aiming at the problems of the lack of reasonable judgment of fleet size and non-optimization of rebalancing for dockless bike-sharing station, based on the usage characteristics of dockless bike-sharing, this paper demonstrates that the Markov chain is ...
Y. Zhai, J. Liu, J. Du, J. Chen
doaj   +1 more source

Early Spatial and Contextual Coding Deficits in Hippocampal CA1 Precede Performance Decline in an Alzheimer's Disease Model

Advanced Science, EarlyView.
Two‐photon calcium imaging in behaving 5xFAD mice reveals early CA1 coding deficits before behavioral decline. Task‐related place cell activity and splitter cell trajectory coding are impaired, with reduced retrospective dominance and greater prospective weighting.
Yimei Li, Mary Ann Go, Hualong Zhang, Robertas Aleksynas, Juliana Kim, Mingyang Gao, Seigfred Prado, Magdalena Sastre, Simon R. Schultz   +8 more
wiley   +1 more source

Bike-sharing trip frequency: Weekday- and weekend-specific fixed-effects regression results where the treatment is the first executive order.

, 2023
Bike-sharing trip frequency: Weekday- and weekend-specific fixed-effects regression results where the treatment is the first executive order.
Ramah Al Balawi (14074236), Ecem Basak (12099608), Sorouralsadat Fatemi (15198299), Ali Tafti (3141339)   +3 more
core   +1 more source

Similarity‐Enhanced Representation Learning of Non‐Canonical Amino Acids for Therapeutic Peptide Modeling

Advanced Science, EarlyView.
Non‐canonical amino acids (ncAAs) enhance peptide therapeutics but remain difficult to model computationally. SinCAA, a similarity‐enhanced pretraining framework, jointly optimizes contrastive learning guided by a novel conformational similarity metric with masked node reconstruction, capturing both functional relationships and chemical identity of ...
Chencheng Xu, Lesong Wei, Jianmin Wang, Yuanpeng Xiong, Ruochi Zhang, Yu Wang, Chao Zha, Qiangcheng Zeng, Xin Gao   +8 more
wiley   +1 more source

Robust Optimization Model Based on a Static Rebalancing Design for Bike- Sharing Systems Affected by Demand Uncertainty

IEEE Access
Demand uncertainty and variations in user rental-return behavior can lead to an uneven spatial distribution of bicycles, which forces bike-sharing operators to rebalance the bike-sharing system by relocating bicycles from overstocked to understocked ...
Lijun Yu, Yaogeng Xu, Haochen Shi, Zhimin Zhang   +3 more
doaj   +1 more source

Molecular Glue Degraders Enhance CAPRIN1‐Dependent Lysosomal Degradation of APP and Reduce Amyloid β in Alzheimer's Disease

Advanced Science, EarlyView.
A new class of lysosome‐directed molecular glue degraders selectively enhance CAPRIN1–APP interactions, driving APP degradation and reducing amyloid‐β production in human neurons and Alzheimer's disease mouse models. This CAPRIN1‐dependent targeted protein degradation strategy reveals a previously unrecognized therapeutic approach for disrupting the ...
Sunghan Jung, Xu Wang, Bin Liu, Raktim Roy, Nancy Jaiswal, Ratan K. Rai, Yuichiro Takagi, Cen Gao, Lifan Zeng, Ho‐Yin Lo, Reagan K. Wohlford, Ryan K. Higgins, Bruce T. Lamb, Anantha Shekhar, Anita C. Bellail, Chunhai Hao   +15 more
wiley   +1 more source

Beyond Nature's Blueprint: Macrocyclic Peptides Containing Unnatural Amino Acids in Therapeutic Development

Angewandte Chemie, EarlyView.
Strategic incorporation of unnatural amino acids transforms macrocyclic peptides into drug‐like molecules capable of engaging challenging targets. These building blocks enhance stability, permeability, and bioavailability, accelerating the development of next‐generation peptide therapeutics.
Krishna K. Sharma, Komal Sharma, Anku Sharma, Kamya Rao, Rahul Jain, Brett VanVeller   +5 more
wiley   +2 more sources