Results 121 to 130 of about 4,493 (261)

Hybrid Macrocyclic Peptides — Synthetic Strategies to Diversify and Cyclize Peptide Libraries in Phage Display Selections

Chemistry – A European Journal, EarlyView.
Hybrid macrocyclic peptides unite genetically encoded peptide libraries with the structural complexity of synthetic small molecules. This Review critically analyzes phage‐compatible cyclization and diversification chemistries, highlights emerging opportunities beyond traditional cysteine‐based approaches, and outlines how future advances may enable the
Titia Rixt Oppewal, Clemens Mayer
wiley   +1 more source

Reversible Assembly and Disassembly of σ‐Aromatic B3 Rings

Chemistry – A European Journal, EarlyView.
B3 rings are the smallest σ‐aromatic boron compounds. Here, we show for the first time that cationic diboranes with an electron‐precise (2c,2e) bond can be reversibly converted to σ‐aromatic B3 rings with electron‐deficient (3c,2e) bonding. Base‐induced disassembly of the B3 ring leads back to cationic diboranes and monoborane adducts.
Julian Krauß, Frederick Koch, Niels Karsten Paul Hecht, Elisabeth Kaifer, Hans‐Jörg Himmel   +4 more
wiley   +1 more source

Mechanistic Insights Into Luminol Chemiexcitation: The Role of the Amide Carbonyls

Chemistry – A European Journal, EarlyView.
By means of quantum‐chemical calculations, we demonstrate that the 1,2‐dioxin ring forms following nitrogen release from parent luminol. We also identify alkoxide groups derived from the amide carbonyls of luminol as key enhancers of the chemiexcitation yield.
Juliana Cuéllar‐Zuquin, Héctor Vila‐Cervera, Angelo Giussani, Daniel Roca‐Sanjuán   +3 more
wiley   +1 more source

A White Paper on Advancing Long‐Acting Therapeutics for Maternal and Pediatric Health by Bridging Gaps in Clinical Research, Access and Regulation

Clinical Pharmacology &Therapeutics, EarlyView.
As use cases for long‐acting therapeutics expand across clinical indications, there is a critical need to ensure the inclusion of women who are pregnant or breastfeeding, infants and children—populations with a historical gap in the availability of interventions already approved for use in adults.
Moherndran Archary, Robert Bies, Osei Boateng, Rachel Daley, Pierre Gashema, Mili Karina, Emily Njuguna, Sharon Nachman, Nathaniel Nkrumah, Carolyne Odula, Andrew Owen, Ethel D. Weld, Prajith Venkatasubramanian, Adeniyi Olagunju, on behalf of the Community of Practice for Long‐acting Therapeutics for Maternal and Paediatric Health, Rana Abutaima, Dorothy Akongo, Abdulnaser Alsharaa, Moherndran Archary, Shakir Atoyebi, Benoit Bestgen, Robert Bies, Osei Boateng, Andrew Butler, Edmund Capparelli, Rachel Daley, Layla Davies, Joelle Dountio, Henry Enzama, Pierre Gashema, Katila George, Dan Hawcutt, Rene Holm, Patrick Gad Iradukunda, Elodie Jambert, Mili Karina, Linda Lewis, Grace Miheso, Sebastien Morin, Andrew Morrison, Sharon Nachman, Shadia Nakalema, Emily Njunga, Nathaniel Nkrumah, Carolyne Odula‐Obonyo, Brenda Okware, Adeniyi Olagunju, Andrew Owen, Martina Penazzato, Natella Rakhmanina, Mphako Brighton Ratlabyana, Rachel Scott, Kimberly Struble, Andre‐Marie Tchouatieu, Catherine Unsworth, Prajith Venkatasubramanian, Catriona Waitt, Ethel Weld, Janine Winterbottom, Leena Zino   +59 more
wiley   +1 more source

Artificial Intelligence as a Catalyst for Environmental and Social Sustainability Practices in SMEs: The Moderating Role of Sustainability, Digitalization, and Innovation Barriers

Corporate Social Responsibility and Environmental Management, EarlyView.
ABSTRACT This study examines the relationship between artificial intelligence and both environmental and social sustainability practices in small and medium‐sized enterprises, with a specific focus on the moderating effects of implementation barriers relating to sustainability, digitalization, and innovation.
Gülçinay Mumcu, Steven A. Brieger
wiley   +1 more source

Shifting Tides: A Decade of Business Climate Adaptation and Resilience Research (2013–2023)

Corporate Social Responsibility and Environmental Management, EarlyView.
ABSTRACT Climate change is causing significant disruptions to the socio‐ecological systems in which organizations operate, presenting unprecedented challenges for businesses across sectors in adapting to shifting environmental conditions and building resilience to extreme weather events.
Domenico Villano, Laura Colli, Federico Martellozzo, Sara Lombardi   +3 more
wiley   +1 more source

Optimization problem of bike-sharing system rebalancing based on dynamic pricing. [PDF]

PLoS One
Cai J, Wen Q, Chen T, Xie L, Yu J, Liu Y.   +5 more
europepmc   +1 more source

Digital and Gender Attributes of IC in Sustainability Reporting of Italian Firms

Corporate Social Responsibility and Environmental Management, EarlyView.
ABSTRACT Italian listed enterprises increasingly rely on intellectual capital (IC) to enhance competitiveness and sustainability performance. As IC, comprising human, structural, and relational capital, is rarely recognised in financial statements due to the lack of standardised frameworks, its disclosure has gained relevance in sustainability ...
Alessandra Buonasera, Simona Catuogno
wiley   +1 more source