Results 21 to 30 of about 643 (132)

Bictegravir Plus Tenofovir Alafenamide Nanoformulation as a Long-Acting Pre-Exposure Prophylaxis Regimen: Application of Modeling to Design Non-Human Primate Pharmacokinetic Experiments

open access: yesFrontiers in Pharmacology, 2020
Bictegravir (BIC) and tenofovir alafenamide fumarate (TAF), two potent anti-HIV drugs, had been nanoformulated (nBIC-TAF) to achieve once-a-month PrEP coverage. In-vivo mouse experiments for nBIC-TAF exhibited favorable subcutaneous (SC) pharmacokinetics.
Simone Perazzolo   +3 more
doaj   +1 more source

The Inflation Reduction Act: A boon for the generic and biosimilar industry

open access: yesJournal of Clinical Pharmacy and Therapeutics, Volume 47, Issue 11, Page 1738-1751, November 2022., 2022
The Inflation Reduction Act gives a significant boost to generics and biosimilars!Soon lowered out‐of‐pocket costBiosimilars promoted and adopted Abstract What is Known and Objective After more than a year of negotiation, a $740 billion climate and health care bill known as The Inflation Reduction Act (IRA) became law on 16 August 2022.
Sarfaraz K. Niazi
wiley   +1 more source

Safe performance of cytoreductive surgery and hyperthermic intraperitoneal chemotherapy in patients with HIV infection

open access: yesCancer Reports, Volume 5, Issue 10, October 2022., 2022
Abstract Background Patients with HIV (PHIV) are living longer with the adoption of anti‐retroviral therapy. As such, more patients are presenting with advanced cancer diagnoses, including peritoneal surface malignancies. The objective of this study was to assess the safety of CRS/HIPEC in this cohort of patients.
Anna Coghill   +6 more
wiley   +1 more source

Safety and Efficacy of Coformulated Bictegravir, Emtricitabine, and Tenofovir Alafenamide Among People Living with HIV-1

open access: yes, 2023
HIV-1 infection is a global health issue. In the past few years, antiretroviral (ARV) drugs has been the common drugs for the treatment of HIV-1. At present, the commonly used daily oral drugs often appear in triple or double combination, which requires ...
ShengNan Zhao, Wenjing Wang
core   +1 more source

1593. Switch to DOVATO in Patients Suppressed on Biktarvy (The SOUND Study), week 48 interim analysis

open access: yesOpen Forum Infectious Diseases, 2023
Abstract Background Dolutegravir/lamivudine(DTG/3TC) is a complete regimen, approved by the FDA for the treatment of HIV-1 infection in treatment-naïve or virologically suppressed patients with no prior virologic failure or resistance to DTG/3TC.
Slim, Jihad   +5 more
openaire   +1 more source

Physiologically‐Based Pharmacokinetic Modeling to Support the Clinical Management of Drug–Drug Interactions With Bictegravir

open access: yesClinical Pharmacology &Therapeutics, Volume 110, Issue 5, Page 1231-1239, November 2021., 2021
Bictegravir is equally metabolized by cytochrome P450 (CYP)3A and uridine diphosphate‐glucuronosyltransferase (UGT)1A1. Drug–drug interaction (DDI) studies were only conducted for strong inhibitors and inducers, leading to some uncertainty whether moderate perpetrators or multiple drug associations can be safely coadministered with bictegravir. We used
Felix Stader   +2 more
wiley   +1 more source

The effect of changing to Bictegravir on lipids using real world data: A brief report [PDF]

open access: yes, 2022
What is known and objective: Cardiovascular disease is of increasing concern in patients living with HIV. The significant advancement in antiretroviral treatment has ensured that patients are now succumbing to traditional diseases of ageing.
Hughes, Elen   +4 more
core   +1 more source

Bictegravir/Emtricitabine/Tenofovir Alafenamide for HIV-1: What is the Hidden Potential of This Emerging Treatment?

open access: yesHIV/AIDS: Research and Palliative Care, 2023
Jenna E Januszka, Emily N Drwiega, Melissa E Badowski University of Illinois at Chicago, College of Pharmacy, Chicago, IL, USACorrespondence: Melissa E Badowski, Clinical Assistant Professor of Pharmacy Practice, Department of Pharmacy Practice, College ...
Januszka JE, Drwiega EN, Badowski ME
doaj  

Outcomes After Switching to BIC/FTC/TAF in Patients with Virological Failure to Protease Inhibitors or Non-Nucleoside Reverse Transcriptase Inhibitors: A Real-World Cohort Study

open access: yesInfection and Drug Resistance, 2021
Hui-Min Chang,1– 3 Pei-Yun Chou,4,5 Chen-Hsi Chou,2 Hung-Chin Tsai4– 6 1Department of Pharmacy, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan; 2Institute of Clinical Pharmacy and Pharmaceutical Sciences, College of Medicine, National Cheng Kung ...
Chang HM, Chou PY, Chou CH, Tsai HC
doaj  

2489. Adverse Events with Biktarvy: Post-Marketing Study

open access: yesOpen Forum Infectious Diseases, 2019
Abstract Background Bictegravir (BIC)/emtricitabine (FTC)/tenofovir alafenamide (TAF) was FDA approved in February 2018. There are no published post-marketing data evaluating safety and efficacy. After large uptake of BIC/FTC/TAF at our institution, reports of rash prompted a real-world review.
Hayes, Edwin   +5 more
openaire   +1 more source

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