Results 111 to 120 of about 982,648 (300)

Disrupted TFEB/GDNF–cAMP/ATP Coupling Underlies Astrocytic Dysfunction and Depression in LRRK2 G2019S Parkinson's Mice

open access: yesAdvanced Science, EarlyView.
ABSTRACT The LRRK2 G2019S mutation, a Parkinson's disease–linked variant, has been associated with depression‐like phenotypes, but mechanisms remain unclear. We chart age‐dependent behavioral changes and astrocyte reactivity in G2019S mice and define a pathway connecting LRRK2 to TFEB/GDNF signaling, cellular energetics, and inflammation.
Longping Yao   +5 more
wiley   +1 more source

Investigation of asymmetry in some morphological characteristics of two freshwater fishes from Iraq

open access: yesOceanological and Hydrobiological Studies
This research aims to investigate the levels of fluctuating asymmetry (FA) in six external morphological traits, along with four meristic traits in two commercially exploited fish species, Cyprinus carpio and Leuciscus vorax.
Fatle Fatema Ali Al, Jawad Laith A.
doaj   +1 more source

Economic costs and payoffs of bilateral/regional trade agreements [PDF]

open access: yes
The rapid increase in the number of bilateral and regional free-trade agreements since 1995 is a striking development. The proliferation of these agreements has raised questions among academicians and policymakers about whether they have, in fact, opened
Hallahan, Charles B.   +1 more
core  

Pre‐Regenerative Endothelial Cells Empowered by Antler Blood Exosomes Orchestrate Peripheral Nerve Repair

open access: yesAdvanced Science, EarlyView.
The pre‐regenerative vascular niche (PVN) is essential for nerve repair, yet its endothelial blueprint remains unclear. We identified angiogenic ECs (AECs) as the dominant pre‐regenerative subset and found that antler blood–derived exosomes (AB‐EXO) promote repair via IMP3.
Jinsheng Huang   +11 more
wiley   +1 more source

Bilateral trade agreements in the Asia Pacific: wise or foolish policies? [PDF]

open access: yes, 2005
Bilateralism is mushrooming in the Asia - Pacific, yet the motives for it remain puzzling. Why do countries devote substantial effort to bilateral free trade agreements that are providing limited additional benefits when compared both with unilateral ...
Dieter, Heribert
core  

Microglial Deubiquitinase OTUD7B Stabilizes STAT3 to Promote Neuroinflammation and Cognitive Decline in Alzheimer's Disease

open access: yesAdvanced Science, EarlyView.
. ABSTRACT Neuroinflammation driven by microglial activation is a defining feature of Alzheimer's disease (AD), yet the molecular mechanisms sustaining this proinflammatory state remain unclear. Here, we identify the deubiquitinase OTUD7B as a critical regulator of microglial activation and AD pathology.
Luyao Li   +15 more
wiley   +1 more source

Bilateral Shoulder Dislocation

open access: yes
This patient suffered a bilateral shoulder dislocation after getting involved in a fight, in which he was held from behind by one of his ...

core  

On construction of robust composite indices by linear aggregation [PDF]

open access: yes
In this paper we construct thirteen different types of composite indices by linear combination of indicator variables (with and without outliers/data corruption). Weights of different indicator variables are obtained by maximization of the sum of squared
Mishra, SK
core  

The effects of entry in bilateral oligopoly [PDF]

open access: yes, 2002
We show that a firm’s profits under Cournot oligopoly can be increasing in the number of firms in the industry if wages are determined by (decentralised) bargaining in unionized bilateral oligopoly.
Naylor, Robin
core  

The Mind From Within: Visceral Roots of Human Cognition

open access: yesAdvanced Science, EarlyView.
The physiological activity of visceral organs, such as the heart, the lungs, and the gut, is surprisingly linked to many sophisticated mental operations, such as remembering the past, being aware of ourselves, making choices, and forging social bonds.
Alessandro Monti   +1 more
wiley   +1 more source

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