Results 151 to 160 of about 982,648 (300)

Computing Classical Power Indices For Large Finite Voting Games. [PDF]

Voting Power Indices enable the analysis of the distribution of power in a legislature or voting body in which different members have different numbers of votes.
Leech, D.
core  

A Small‐Molecule DEPTAC Rescues Cognitive Deficits by Targeted Dephosphorylation of Pathological Tau

Advanced Science, EarlyView.
TP2 is a fully synthetic small‐molecule dephosphorylation‐targeting chimera that recruits endogenous PP2A‐Bα to Tau, enabling targeted removal of pathological phosphate modifications. In two tauopathy mouse models, systemic TP2 reduces Tau pathology, preserves neuronal and synaptic integrity, improves neuroimmune homeostasis, and rescues cognition ...
Fei Sun, Yang Liu, Qiuzhi Zhou, Qingyuan Hu, Weixia Wang, Yue Xiao, Jingfen Su, Guanting Liu, Miaomiao Sun, Lixia Chen, Hua Li, Ying Yang, Jian‐Zhi Wang   +12 more
wiley   +1 more source

Compensatory proximal malalignment despite preserved macroscopic gait in pediatric flexible flatfoot: A dual-level analysis of static alignment and dynamic kinematics. [PDF]

PLoS One
Wang H, Li M, Liang X, Wang W, Luo P, Zhang J, Du Y, Liu T, Zhang B, Wang X, Jin Z, Zhu Y, Han T.   +12 more
europepmc   +1 more source

Assessing scientific research performance and impact with single indices [PDF]

We provide a comprehensive and critical review of the h-index and its most important modifications proposed in the literature, as well as of other similar indicators measuring research output and impact.
Panaretos, John, Malesios, Chrisovaladis
core  

Entorhinal Astrocyte Transplants Restore Spatial Exploration and Alleviate Amyloid‐Beta Pathology in Alzheimer's Mice

Advanced Science, EarlyView.
Impaired MEC astrocytic Ca2+ signaling is associated with fragmented spatial exploration in AD mice. Region‐specific glial progenitor transplantation generates engrafted astrocytes that are accompanied by improved AQP4 polarization, reduced amyloid‐β‐associated pathology, attenuated neuroinflammation, preserved synaptic integrity, and ameliorated ...
Fengjuan Wu, Jihua Fan, Xiang Zhou, Zhiqi Yang, Mingyue Gong, Mingzhu Huang, Zhenlu Cai, Shaofan Yang, Teng Teng, Chuanyan Yang, Jin Li, Haoyu Wang, Shuangshuang Dai, Chunhai Chen, Xiaowei Chen, Manxia Wang, Kuan Zhang   +16 more
wiley   +1 more source

TRPC3‐Driven Calcium Microdomains Instruct Peripheral Nerve Regeneration With Protective Implications for Central Neurons

Advanced Science, EarlyView.
How localized Ca2+ signals orchestrate neural repair remains unclear. Here, we show that TRPC3‐driven calcium microdomains direct nerve repair by coupling spatially confined Ca2+ signals to axon regeneration. This module operates in injured peripheral neurons and correlates with neuroprotection in Parkinson's disease, revealing a spatial logic for ...
Yu Lu, Jianbo Zhao, Zhenli Xie, Yuan Wang, Ruolin Wang, Bianbian Wang, Chuhan Shen, Yali Chen, Jingyu Yao, Ziyang Li, Huadong Xu, Zuying Chai, Zhuoyu Zhang, Changhe Wang, Rong Huang   +14 more
wiley   +1 more source

Predictive Performance of Simplified First-Trimester Placental Volume Estimation Combined with Uterine Artery Doppler and Maternal Serum Biomarkers for Preeclampsia and Fetal Growth Restriction: A Retrospective Cohort Study. [PDF]

Metabolites
Kel Ilgın S, Duran MN, Sarıdaş Demir S, Demir B.   +3 more
europepmc   +1 more source

Perceived Time Shapes Physical Fatigue Accumulation and Its Neural Oscillatory Correlates

Advanced Science, EarlyView.
Can a clock change the course of physical fatigue? By covertly manipulating the clock calibration during repeated isometric contractions, we showed that perceived time shapes fatigue accumulation and frontal oscillatory dynamics. While fatigue accumulation was only reduced when the clock was slowed down, frontal oscillatory dynamics followed perceived ...
Pierre‐Marie Matta, Julien Duclay, Robin Baurès, Andrea Alamia   +3 more
wiley   +1 more source

A Case Report on Cerebral Autoregulation in Posterior Reversible Encephalopathy Syndrome After Aneurysmal Subarachnoid Hemorrhage. [PDF]

Crit Care Explor
Weiss M, Kastenholz N, Conzen-Dilger C, Clusmann H, Park S, Schubert GA.   +5 more
europepmc   +1 more source

TAB2 Causes Neuronal Damage by Aggravating Microglia‐Mediated Neuroinflammation in Parkinson's Disease

Advanced Science, EarlyView.
In microglia, STAT3 upregulates TAB2, which promotes NF‐κB activation through its NZF domain‐mediated recognition of K63‐linked ubiquitin chains, leading to inflammatory cytokine release and subsequent neuronal injury. Lumacaftor suppresses TAB2 expression and directly binds the TAB2‐NZF domain to interrupt K63 ubiquitin recognition, thereby blocking ...
Yanhao Zhao, Zimeng Huang, Jianing Gao, Aolan Li, Huizhi Wang, Yingchuan Chen, Guanyu Zhu, Xin Zhang, Yin Jiang, Moxuan Zhang, Fangang Meng, Jianguo Zhang, Tingting Du   +12 more
wiley   +1 more source