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Neurodevelopmental Phenotypes and Brain Anomalies in Individuals With Heterozygous SEMA6A Variants

Clinical Genetics, Volume 110, Issue 3, Page 325-335, September 2026.
SEMA6A plays a role in cell migration and axon guidance in the developing central nervous system. Phenotypes seen in eleven individuals heterozygous for SEMA6A variants included developmental delay, intellectual disability, autism/autistic behaviors, behavioral abnormalities, attention disorders, hypotonia, and brain anomalies.
Evan Burchfiel +27 more
wiley +1 more source

Artificial Intelligence‐Based Approach for Determining the Risk of Temporomandibular Disorders

Journal of Oral Rehabilitation, Volume 53, Issue 9, Page 1665-1674, September 2026.
AI‐based model aims to be a practical decision support tool for early diagnosis and prevention of temporomandibular disorders, ultimately contributing to better clinical care and patient well‐being. ABSTRACT Objectives This study aims to predict TMD using ML approaches based on clinical and sociodemographic variables to aid in the early detection and ...
Damla Torul +4 more
wiley +1 more source

Old dog, new trick: Charybdotoxin as a novel ryanodine receptor blocker

The Journal of Physiology, Volume 604, Issue 17, Page 7246-7263, 1 September 2026.
Abstract figure legend The peptide toxin charybdotoxin (ChTx) from the scorpion Leiurus quinquestriatus was tested on single‐channel currents of the ryanodine receptor incorporated into planar lipid bilayers. The structure–function relationship of ChTx was investigated using toxin variants generated by isosteric substitutions of the basic amino acids ...
Zsuzsanna Édua Magyar +10 more
wiley +1 more source

Visual Input Is the Main Trigger and Parametric Determinant for Catch-Up Saccades During Video Head Impulse Test in Bilateral Vestibular Loss. [PDF]