Results 91 to 100 of about 309,439 (265)

Cobalt Single‐Atom Nanozyme for Enhanced Intestinal Radioprotection and Tumor Radiosensitization via Bidirectional ROS Modulation

Advanced Science, EarlyView.
Orally administered, pH‐responsive Co‐SAN exerts dual functions: in the alkaline intestinal milieu, it scavenges reactive oxygen species (ROS) and suppresses the PI3K/AKT pathway and NETs formation, thus providing radioprotection; whereas in the acidic tumor microenvironment, it generates ROS and alleviates hypoxia, thereby enhancing radiosensitization.
Shengqi Yin, Junjie Li, Yishu Zou, Yang Liu, Yilin Zheng, Lu Yu, Wanying Zheng, Yajun Zou, Zehui Zhang, Tao Li, Peiqun Yin, Jianlin Zhang, Yuen Wu, Yi Ding   +13 more
wiley   +1 more source

Commentaire: M. Gagarin - P. Perlman, The Laws of Ancient Crete, c.650-400 B. C., Oxford 2016, 566 p. en abrégé GP

Dike, 2018
Monique Bile
doaj   +1 more source

The Metabolic Pathway of Bile Secretion Is Vulnerable to Salmonella enterica Exposure in Porcine Intestinal Epithelial Cells

Animals
Pigs can be colonized with Salmonella enterica and become established carriers. However, the mechanisms of the host’s response to Salmonella enterica infection are largely unclear.
Jiajia Cai, Xiaolei Chen, Chao Xu, Xiaoyang Zhu, Haifei Wang, Shenglong Wu, Demin Cai, Hairui Fan   +7 more
doaj   +1 more source

Mechanical Flexibility Enables DNA Origami to Overcome Steric Confinement in Mucus

Advanced Science, EarlyView.
Mechanical flexibility is introduced as a design parameter to enhance nanocarrier transport in mucus. Using DNA origami, flexibility is decoupled from size, shap and surface chemistry, revealing improved passage through confined hydrogel networks. While surface passivation reduces aggregation, flexibility further boosts transport, offering a general ...
Matteo Tollemeto, Emily Tsang, Marie Karen Tracy Hong Lin, Luca Mannino, Kurt V. Gothelf, Anja Boisen   +5 more
wiley   +1 more source

HMGCR‐Driven Cholesterol Metabolism Promotes Osteoarthritis Progression by Accelerating Synovial Fibroblast Senescence

Advanced Science, EarlyView.
In the pathological context of osteoarthritis (OA), the phosphorylation of AKT1 at Ser473 enhances its binding to Lys140 of Insig1, which facilitates the formation of AKT1–Insig1 complex. Subsequently, the activation of AKT1 promotes the phosphorylation of Insig1 at Ser189, potentially enhancing the dissociation of Insig1 from sterol regulatory element‑
Xiaoqi Zhang, Siru Zhou, Xi Liu, Wei Xiang, Xiuqin Peng, Yu Tian, Song Li, Hailin Wang, Bo Liao, Shunzheng Fang, Runze Jin, Jinhui Wu, Chuanqing Bai, Wei Zhang, Bo Huang, Bingfei Li, Lifeng Chen, Lin Chen, Bin Zhang, Zhenhong Ni   +19 more
wiley   +1 more source

Moderate increase in dietary fat induces alterations of microbiota and metabolome along the digestive tract prior to systemic metabolic changes: insights from a pig model

Gut Microbes
The small intestine is a key site for nutrient sensing and host–microbiota interactions, yet how it functionally adapts to dietary changes remains poorly understood.
Axel Ranson, Marta Vazquez Gomez, Rohia Alili, Julia Duraffourd, Oriane Vitalis, Paul Taillandier, Clémentine Rebière, Fatiha Merabtene, Eugeni Belda, Daniel Crespo-Piazuelo, Antonio Gonzalez-Bulnes, Geneviève Marcelin, Adil Mardinoglu, Karim Chikh, Tiphaine Le Roy, Karine Clément   +15 more
doaj   +1 more source

Chemoselective Metabolomics via a Modular Reactivity‐Encoding Platform

Advanced Science, EarlyView.
Conventional LC–MS underrepresents numerous metabolites due to heterogeneous ionization efficiencies and matrix interference. Here, we introduce a modular reactivity‐encoding platform (MREP) comprising four alkyne‐tagged probes that selectively derivatize key functional groups, followed by unified click‐chemistry capture to eliminate matrix components ...
Xin Tao, Cang‐Man Zhang, Ru‐Jie Yang, Min Ren, Zhuo‐Ling Zhong, Kang‐Hui Wang, Rui‐Xue Hu, Jia‐Yue Liu, Jun‐Yi Zhou, Hou‐Kai Li, Jian‐Bo Wan   +10 more
wiley   +1 more source

A study on bile from patients with recurrent common bile duct stones and cholangiocarcinoma following ERCP using non-targeted metabolomics

Frontiers in Medicine
ObjectiveThis study aimed to analyze bile samples from patients with common bile duct stones and cholangiocarcinoma using non-targeted liquid chromatography-mass spectrometry (LC-MS)-based metabolomics, in order to identify disease-associated ...
Yong-Kai Kuang, Yu-Tong Wu, Dan-Dan Wang, Gao-Feng Lu   +3 more
doaj   +1 more source

Molecular Dynamics‐Guided Sterol Engineering of mRNA‐Lipid Nanoparticles Reprograms Biodistribution and Enhances Spleen‐Selective Immunity

Advanced Science, EarlyView.
Sterol engineering enables precise control of mRNA lipid nanoparticles by tuning membrane organization. Replacing cholesterol with bile acid‐derived sterols redirects protein expression from the liver to the spleen. Notably, CA‐20 LNP enhances antigen‐specific immune responses while exhibiting a favorable safety profile, highlighting sterols as a ...
Sanghyuk Jeon, Seo‐Hyeon Bae, Jungyong Ji, Jisun Lee, Hosam Choi, Min‐Ho Kang, Sang‐In Park, Hyemin Kim, Nakyung Lee, Hajin Lee, Seonghoon Kim, Jungmin Kim, Subin Yoon, Seonghyun Lee, Seongje Cho, Dahyeon Ha, Ayoung Oh, Sohee Jo, Huijeong Choi, Yeeun Lee, Sowon Lee, Hyo‐Jung Park, Gitak Nam, Jisu Shin, Yujin Kang, Wonpil Im, Kiyoun Lee, Jae‐Hwan Nam   +27 more
wiley   +1 more source

Profiling bile acid composition in bile from mice of different ages and sexes

Frontiers in Physiology
IntroductionBile BA profiling is important for understanding the pathogenetic mechanisms underlying gallbladder and gastrointestinal diseases. Until now, bile BAs have been explored mainly in adult male mice.
Jiajian Liu, Qing Zhao, Chun Qu, Kun Ge, Yang Li, Wei Jia, Aihua Zhao   +6 more
doaj   +1 more source