Results 201 to 210 of about 309,439 (265)

From "Monarch, Minister, Assistant, and Envoy" to "Microbial Dialogue": A Review of Novel Mechanisms by Which Chinese Herb Pairs Improve Metabolic Diseases Through Gut Microbiota Metabolic Regulation. [PDF]

Gastroenterol Res Pract
Wang Z.
europepmc   +1 more source

Ceftriaxone‐induced liver injury: Incidence, phenotypic characterization and predictive factors

British Journal of Clinical Pharmacology, EarlyView.
Introduction Ceftriaxone is a widely used third‐generation cephalosporin in hospitalized patients. Although generally considered safe, it has been associated with hepatobiliary complications and emerging reports of drug‐induced liver injury (DILI). However, data on its true incidence, phenotypic patterns, and predictors remain limited. This study aimed
Mohamed Hatem, Mohannad N. AbuHaweeleh, Humam Emad Rajha, Mhd Osama Rahhal, Ahmad Hamdan, Lina Naseralallah   +5 more
wiley   +1 more source

Resveratrol ameliorates intrahepatic cholestasis of pregnancy by modulating the gut-liver axis and FXR-mediated bile acid homeostasis. [PDF]

Front Immunol
Hu N, Yang Y, Chen R, Guan J, Gu H, Zhang L, Zhang X, Wang X, Zhang L.   +8 more
europepmc   +1 more source

UGT1A1 genotype testing for irinotecan: A guideline developed by the UK Centre of Excellence in Regulatory Science and Innovation in Pharmacogenomics (CERSI‐PGx)

British Journal of Clinical Pharmacology, EarlyView.
Abstract Irinotecan, a topoisomerase I inhibitor, is available as both non‐pegylated and pegylated formulations. The non‐pegylated formulation is licensed for use in advanced colorectal cancer either in combination with other agents or as monotherapy.
Dharmisha Chauhan, Cinzia Dello Russo, Jack Thompson, Dyfrig A. Hughes, Katherine Payne, Maria Tsakiroglou, Paul Ross, Rena Chauhan, Simon Jenkinson, Jessica Keen, Sophie Harding, Eleanor Lau, Michael Braun, Roshan Agarwal, Richard Adams, Elisabeth Rolf, Farah Al‐Sheikhli, Sarah Mitchell, Ruth Hammond, Rosie Roberts, Lorna Cairns, Shirley Heggarty, Janet Graham, Justin Mencel, Munir Pirmohamed   +24 more
wiley   +1 more source

Delayed Diagnosis of Low Phospholipid-Associated Cholelithiasis Syndrome, Consideration of DHCR7 Mutations. [PDF]

ACG Case Rep J
Meltzer OA, Medina SP, Ibarra A, Davis BG, Goldman ML, Mukhtar NA.   +5 more
europepmc   +1 more source

A descriptive case series of hepatotoxicity associated with CFTR modulators and possible relevance of pharmacogenetic polymorphisms in cystic fibrosis patients

British Journal of Clinical Pharmacology, EarlyView.
Cystic fibrosis transmembrane conductance regulator (CFTR) modulators are widely used in patients with cystic fibrosis and significantly improve respiratory function and quality of life. However, their effectiveness may be limited by liver damage, which sometimes leads to treatment discontinuation, and the mechanisms underlying this remain poorly ...
Clara Laffitte Redondo, Venceslas Bourdin, Abd El Kader Ait Tayeb, Sihem Benaboud, Inès Martins, Caroline Joyau, Myriam Benhamida, Isabelle Sermet‐Gaudelus, Clémence Martin, Pierre Régis Burgel, Céline Verstuyft, Laurent Chouchana, Estelle Ayme‐Dietrich   +12 more
wiley   +1 more source

Safety and efficacy analysis of in vivo lentiviral gene therapy in pre-clinical ARC syndrome models. [PDF]

Nat Commun
Cozmescu CA, Nazari M, Touramanidou L, Gurung S, Perocheau D, Sebire N, Hu YT, Goldsworthy S, Burden JJ, Khalil Y, Doykov I, Counsell JR, Karda R, Castellano S, Mills P, Clayton P, Heywood W, Moulding D, Waddington SN, Baruteau J, Turchiano G, Gissen P.   +21 more
europepmc   +1 more source

Effects of Dietary Glycerol Monolaurate on Growth Performance, Bile Acid Metabolism, and Intestinal Health in Asian Swamp Eel (<i>Monopterus albus</i>). [PDF]

Animals (Basel)
Liu H, Yang H, Guo X, Lin M, Zhao M, Zhou W, Cai H.   +6 more
europepmc   +1 more source

A guide for establishing patient-derived organoids from bile samples obtained during endoscopic procedures and performing gene expression knockdown. [PDF]

Front Cell Dev Biol
Rojo C, Vila JJ, Guembe L, Arrubla-Gamboa A, Jusué-Irurita V, Carrascosa-Gil J, Rullan M, Rández-Garbayo J, Fernández-Barrena MG, Huch M, Urman J, Ávila MA, Berasain C, Arechederra M.   +13 more
europepmc   +1 more source