Results 321 to 330 of about 5,534,791 (400)

Open‐Chain Tetrapyrroles Meet Metal Ions in the Functional Molecular Material Science

ChemPlusChem, EarlyView.
Open‐chain tetrapyrroles, synthesized via oxidative cleavage and condensation, offer greater structural flexibility than cyclic counterparts like porphyrins. Their tunable electronic and geometric properties through metalation enable applications in bioimaging, therapies, ion sensing, chiroptical materials, and spintronic devices, making them valuable ...
Aninda Ghosh, Sandipa Bhandari, Hiroyuki Furuta, Masatoshi Ishida   +3 more
wiley   +1 more source

New therapeutic concepts in bile acid transport and signaling for management of cholestasis

Hepatology, 2017
M. Trauner, C. Fuchs, E. Halilbasic, G. Paumgartner   +3 more
semanticscholar   +1 more source

Gut microbiota regulates hepatic ketogenesis and lipid accumulation in ketogenic diet-induced hyperketonemia by disrupting bile acid metabolism. [PDF]

Gut Microbes
Luo Z, Huang Y, Yong K, Wu D, Zheng L, Yao X, Shen L, Yu S, Wang B, Cao S.   +9 more
europepmc   +1 more source

Inhibition of OATP1B1/3 Rather Than UGT1A1 May Be the Major Cause of the Bilirubin Elevation After Atazanavir Administration

Clinical Pharmacology &Therapeutics, EarlyView.
Atazanavir has been reported to increase total serum bilirubin level up to ninefold. It is widely believed that the observed total bilirubin elevation is primarily due to UGT1A1 inhibition. However, UGT enzymes are well‐known as a low‐affinity and high‐capacity system, and the observed drug–drug interaction mediated by UGTs is usually less than twofold.
Jin Dong, Pradeep Sharma, Rasha Emara, Derek Cheung, Weifeng Tang, Diansong Zhou, David W. Boulton, Mats Någård, Miki S. Park   +8 more
wiley   +1 more source

A Gallbladder-Specific Hydrophobic Bile Acid-FXR-MUC1 Signaling Axis Mediates Cholesterol Gallstone Formation. [PDF]

Adv Sci (Weinh)
Chen H, Jiang X, Li Y, Guo H, Wu J, Li S, Hu F, Xu G.   +7 more
europepmc   +1 more source

SLCO1B1 Functional Variants, Bilirubin, Statin‐Induced Myotoxicity, and Recent Sub‐Saharan African Ancestry: A Precision Medicine Health Equity Study

Clinical Pharmacology &Therapeutics, EarlyView.
Statin pharmacogenetic implementation guidelines are derived from evidence of primarily Eurocentrically biased study populations. Functional SLCO1B1 variants that are rare in these study populations have not been equitably investigated and are thus missing from guidelines.
Tanushree Haldar, Mark Kvale, Jia Yang, Michael P. Douglas, Willow Coyote‐Maetas, Linda Kachuri, John S. Witte, Carlos Iribarren, Marisa W. Medina, Ronald M. Krauss, Sook Wah Yee, Akinyemi Oni‐Orisan   +11 more
wiley   +1 more source

The Synthesis of Stero-bile Acid. IV. The Partial Synthesis of Norsterocholic Acid

, 1953
Tatsumi BABA
openalex   +2 more sources

Microbiota-produced immune regulatory bile acid metabolites control central nervous system autoimmunity. [PDF]

Cell Rep Med
Antonini Cencicchio M, Montini F, Palmieri V, Massimino L, Lo Conte M, Finardi A, Mandelli A, Asnicar F, Pavlovic R, Drago D, Ungaro F, Andolfo A, Segata N, Martinelli V, Furlan R, Falcone M.   +15 more
europepmc   +1 more source

Identification and Clinical Evaluation of Potential Biomarkers for Breast Cancer Resistance Protein (BCRP/ABCG2)

Clinical Pharmacology &Therapeutics, EarlyView.
Clinical inhibition and genetic variation of the Breast Cancer Resistance Protein (BCRP/ABCG2) efflux transporter can significantly influence drug exposure, highlighting the need for reliable BCRP functional biomarkers. This study aimed to identify and evaluate biomarkers predictive of BCRP function in humans.
Andrew M. Riselli, Sook Wah Yee, Jia Yang, Claire M. Brett, Kelsey Trumbach, Xujia Zhou, Renmeng Liu, Xiaomin Liang, Yurong Lai, Runlan Huo, Yongjun Xue, Hong Shen, Lei Zhang, Xinning Yang, Qi Liu, Shiew‐Mei Huang, Kathleen M. Giacomini   +16 more
wiley   +1 more source