Results 141 to 150 of about 759,424 (401)
Bile acids trigger cholemic nephropathy in common bile‐duct–ligated mice
Tubular epithelial injury represents an underestimated but important cause of renal dysfunction in patients with cholestasis and advanced liver disease, but the underlying mechanisms are unclear.
P. Fickert+17 more
semanticscholar +1 more source
Cholestatic liver disease is characterized by gut dysbiosis and excessive toxic hepatic bile acids (BAs). Modification of gut microbiota and repression of BA synthesis are potential strategies for the treatment of cholestatic liver disease.
Yunhuan Liu+15 more
semanticscholar +1 more source
This study uncovers the activation, heterogeneity, and regulatory roles of pancreatic stellate cells (PSCs) at single‐cell and spatial levels. It further identifies PLXDC1+ PSCs near aggressive LRRC15+ cancer‐associated myofibroblasts and SPP1+ macrophages, forming a desmoplastic and immunosuppressive tumor niche that promotes CD8+ T cell exhaustion ...
Yanhua Du+12 more
wiley +1 more source
Six Rare Biliary Tract Anatomic Variations: Implications for Liver Surgery
Objective: The variations in the anatomy of the biliary tract need to be recognized in modern liver surgery. The purpose of this clinical and anatomical study is to describe several novel biliary tract variations and to outline their practical importance
Daniel V. Kostov, Georgi L. Kobakov
doaj
On turbulent friction in straight ducts with complex cross section: the wall law and the hydraulic diameter [PDF]
We develop predictive formulas for friction resistance in ducts with complex cross-sectional shape based on the use of the log law and neglect of wall shear stress nonuniformities. The traditional hydraulic diameter naturally emerges from the analysis as the controlling length scale for common duct shapes as triangles and regular polygons. The analysis
arxiv +1 more source
BACKGROUND & AIMS Limited endoscopic sphincterotomy with large balloon dilation (ESBD) is an alternative to endoscopic sphincterotomy (ES) for removing bile duct stones, but it is not clear which procedure is most effective.
A. Teoh+8 more
semanticscholar +1 more source
Silk Fibroin Nanoparticles for Enhanced Cuproptosis and Immunotherapy in Pancreatic Cancer Treatment
Cuproptosis can be triggered via intracellular copper overload mediated by elesclomol (ES).Enhancing ES‐Cu's tumor targeting and circulation stability can efficiently induce tumor cuproptosis. TSF@ES‐Cu protect ES‐Cu, target tumors via natural RGD sequences, and release through multi‐responsiveness.
Si Gao+7 more
wiley +1 more source
Recurrent chemical pancreatitis complicating choledochal cystic disease [PDF]
A seventeen year old lady presented with a twelve year history of self-limiting attacks of severe epigastric pain, associated with occasional fever, normal total white cell count (WCC), normal or mildly elevated serum alanine transaminase (ALT) (13-200iu/
Pullicino, Edgar
core
Spontaneous common bile duct perforation due to chronic pancreatitis, presenting as a huge cystic retroperitoneal mass: a case report [PDF]
Spontaneous perforation of the bile duct, is a disease in which spontaneous perforation occurs in the wall of the extrahepatic or intrahepatic duct without any traumatic or iatrogenic injury and more often described in neonates.
Kebapçı, Mahmut+2 more
core +2 more sources
Endoscopic management of difficult common bile duct stones.
Endoscopy is widely accepted as the first treatment option in the management of bile duct stones. In this review we focus on the alternative endoscopic modalities for the management of difficult common bile duct stones. Most biliary stones can be removed
G. Trikudanathan+2 more
semanticscholar +1 more source