Results 301 to 310 of about 821,293 (407)

The Contribution of Cholesterol and Squalene Synthase in Cancer: Molecular Mechanisms, Lipid Rafts and Therapeutic Approaches

open access: yesMedicinal Research Reviews, EarlyView.
ABSTRACT A plethora of cellular signaling pathways are dysregulated in cancer cells, promoting carcinogenesis and migration. Cholesterol has recently been linked to cancer by several subcellular mechanisms, especially by its involvement in the formation of lipid rafts, which promote oncogenic signaling and cancer cell invasion. Squalene synthase (SQS),
Danai Mavridi   +2 more
wiley   +1 more source

Limy Bile in the Common Bile Duct

open access: yesInternational Journal of Clinical Practice, 1961
openaire   +2 more sources

Validation of Intravoxel Incoherent Motion MRI Using Perfused Explanted Human Livers

open access: yesMagnetic Resonance in Medicine, EarlyView.
ABSTRACT Purpose Evaluate the feasibility of using perfused explanted human livers for validating intravoxel incoherent motion (IVIM). Methods Eight (n = 8) explanted livers from deceased donors were obtained. The portal vein and hepatic artery of each explanted liver were connected to a perfusion system.
Gregory Simchick   +6 more
wiley   +1 more source

Highly Reproducible, Vendor‐Agnostic, Motion‐Insensitive Liver PDFF Mapping at 0.55T, 1.5T, and 3T

open access: yesMagnetic Resonance in Medicine, EarlyView.
ABSTRACT Purpose To develop and validate a vendor‐agnostic, motion‐insensitive proton‐density fat‐fraction (PDFF) quantification method. Methods Flip‐angle‐modulated (FAM) 2D chemical‐shift‐encoded (CSE) MRI for PDFF quantification was implemented in both the vendor‐agnostic platform Pulseq (“Pulseq‐FAM”) and one vendor‐specific platform (“GE‐specific ...
Jiayi Tang   +27 more
wiley   +1 more source

Bile Acid Binding Resins Improve Glucagon Receptor Agonist‐Mediated Weight Loss in Diet‐Induced Obese Mice

open access: yesObesity, EarlyView.
ABSTRACT Objective Glucagon‐receptor (GCGR) agonism reguglates bile acid (BA) metabolism and promotes weight loss in diet‐induced obese (DIO) mice. Thus, we hypothesized that BA signaling contributes to GCGR‐stimulated weight loss. Methods To test this hypothesis, we utilized BA‐binding resins (BARs; colesevelam [Colsv] and cholestyramine [Cstyr]) to ...
Teayoun Kim   +9 more
wiley   +1 more source

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