Results 161 to 170 of about 256,130 (396)

Phase Ib study of anlotinib combined with TQB2450 in pretreated advanced biliary tract cancer and biomarker analysis

Hepatology, EarlyView., 2022
Phase 1b study of anlotinib combined with TQB2450 in pretreated advanced biliary tract cancer and biomarker analysis. Abstract Background and Aims We evaluated the efficacy and safety of the antiangiogenic tyrosine kinase inhibitor anlotinib plus TQB2450, a programmed death‐ligand 1 inhibitor in pretreated advanced biliary tract cancers (BTCs ...
Jun Zhou, Yongkun Sun, Wen Zhang, Jiajia Yuan, Zhi Peng, Wei Wang, Jifang Gong, Lin Yang, Yanshuo Cao, Hong Zhao, Chao Chen, Weifeng Wang, Lin Shen, Aiping Zhou   +13 more
wiley   +1 more source

Updated risk prediction model for pancreaticoduodenectomy using data from the National Clinical Database in Japan

Annals of Gastroenterological Surgery, EarlyView.
The calibration plots of the updated risk models for the endpoints were analyzed in each cohort. The predicted probability of each endpoint matched the observed probability in the development and validation cohorts. Abstract Aim Risk prediction models for mortality, severe postoperative complications, and postoperative pancreatic fistula in patients ...
Masamichi Mizuma, Hideki Endo, Hiroyuki Yamamoto, Mitsuhiro Shimura, Masahiro Iseki, Michiaki Unno, Taro Oshikiri, Yoshihiro Kakeji, Ken Shirabe   +8 more
wiley   +1 more source

Multiomics identifies the link between intratumor steatosis and the exhausted tumor immune microenvironment in hepatocellular carcinoma

Hepatology, EarlyView., 2022
Steatotic HCC can be diagnosed by MRI and forms a pro‐tumor immune microenvironment with high expression of PD‐L1, M2 polarization of macrophages and activation of CAFs, which may be a good target for combined immunotherapy. Abstract Background and Aims Immunotherapy has become the standard‐of‐care treatment for hepatocellular carcinoma (HCC), but its ...
Hiroki Murai, Takahiro Kodama, Kazuki Maesaka, Shoichiro Tange, Daisuke Motooka, Yutaka Suzuki, Yasuyuki Shigematsu, Kentaro Inamura, Yoshihiro Mise, Akio Saiura, Yoshihiro Ono, Yu Takahashi, Yota Kawasaki, Satoshi Iino, Shogo Kobayashi, Masashi Idogawa, Takashi Tokino, Tomomi Hashidate‐Yoshida, Hideo Shindou, Masanori Miyazaki, Yasuharu Imai, Satoshi Tanaka, Eiji Mita, Kazuyoshi Ohkawa, Hayato Hikita, Ryotaro Sakamori, Tomohide Tatsumi, Hidetoshi Eguchi, Eiichi Morii, Tetsuo Takehara   +29 more
wiley   +1 more source

A TGFβ-ECM-integrin signaling axis drives structural reconfiguration of the bile duct to promote polycystic liver disease [PDF]

, 2023
Scott H. Waddell, Yuelin Yao, Paula Olaizola, Alexander Walker, Edward J. Jarman, Konstantinos Gournopanos, Andreea Grãdinaru, Ersi Christodoulou, Philippe Gautier, Melissa M. Boerrigter, Massimiliano Cadamuro, Luca Fabris, Joost P.H. Drenth, Timothy J. Kendall, Jesús M. Bañales, Ava Khamseh, Pleasantine Mill, Luke Boulter   +17 more
openalex   +1 more source

Prognostic value of surgical treatment in elderly patients with ulcerative colitis‐associated colorectal cancer: A subanalysis of a nationwide Japanese multicenter study

Annals of Gastroenterological Surgery, EarlyView.
Our study examined the characteristics of elderly patients diagnosed with ulcerative colitis‐associated colorectal cancer. We showed that factors associated with aggressive tumor characteristics played a significant role in recurrence risk in the nonelderly patients, but not in the elderly patients.
Kinuko Nagayoshi, Yusuke Mizuuchi, Masafumi Nakamura, Koji Okabayashi, Motoi Uchino, Hiroki Ikeuchi, Tatsuki Noguchi, Soichiro Ishihara, Yoichi Ajioka, Kenichi Sugihara, from the Study Group for Inflammatory Bowel Disease Associated Intestinal Cancers by the Japanese Society for Cancer of the Colon and Rectum   +10 more
wiley   +1 more source

Proteogenomic characterization of cholangiocarcinoma

Hepatology, EarlyView., 2022
Proteogenomic characterization of cholangiocarcinoma with therapeutic strategies Abstract Background and Aims Cholangiocarcinoma (CCA) is a highly heterogeneous cancer with limited understanding and few effective therapeutic approaches. We aimed at providing a proteogenomic CCA characterization to inform biological processes and treatment ...
Mengjie Deng, Peng Ran, Lingli Chen, Yunzhi Wang, Zixiang Yu, Ke Cai, Jinwen Feng, Zhaoyu Qin, Yanan Yin, Subei Tan, Yang Liu, Chen Xu, Guoming Shi, Yuan Ji, Jian‐Yuan Zhao, Jian Zhou, Jia Fan, Yingyong Hou, Chen Ding   +18 more
wiley   +1 more source

Title: Presence of fatty liver disease leads to unusual rise of liver enzymes in patients with common bile duct colic. [PDF]

, 2023
R. C. Siriwardana, Deleepa Senajith Ediriweera, Lakmali Paranaheva, Chanaka Sandharuwan Ekanayake, Suchintha Thilakarathne   +4 more
openalex   +1 more source

Nationwide medical database study for postoperative nutritional management in patients undergoing gastroenterological cancer surgery

Annals of Gastroenterological Surgery, EarlyView.
The study aim was to clarify how nutrition was managed in patients based on surgical site during the first 7 d after gastrointestinal cancer surgery. As results, oral intake after gastrointestinal cancer surgery started earliest in patients having liver surgery and latest in patients having esophageal surgery.
Yoshikuni Kawaguchi, Kenta Murotani, Nahoki Hayashi, Satoru Kamoshita   +3 more
wiley   +1 more source

Correlation of mechanical factors and gallbladder pain [PDF]

, 2008
Acalculous biliary pain occurs in patients with no gallstones, but is similar to that experienced by patients with gallstones. Surgical removal of the gallbladder (GB) in these patients is only successful in providing relief of symptoms to about half of ...
Bird, N.C., Chin, S.B., Hill, N.A., Johnson, A.G., Li, W.G., Luo, X.Y., Smythe, A.   +6 more
core   +3 more sources

Accepting Our Technical Limitations: Intraoperative Bile Duct Margin in Perihilar Cholangiocarcinoma Reflects Disease Biology [PDF]

, 2023
Seth J. Concors, Rebecca A. Snyder
openalex   +1 more source