Results 41 to 50 of about 15,104 (253)
Advanced Science, EarlyView.Gemcitabine resistance remains a major challenge in pancreatic ductal adenocarcinoma. This study identifies STYK1 as a key mediator of chemoresistance through autophagy‐dependent maintenance of cancer stemness. Gemcitabine‐activated AMPK phosphorylates STYK1 at Ser91 and Ser304, enhancing autophagy and stemness.
Xueying Dong +20 more
wiley +1 more source
AASLD practice guidance on drug, herbal, and dietary supplement–induced liver injury
, 2022 Hepatology, EarlyView.
Robert J. Fontana +6 more
wiley +1 more source
T-tube vs Primary Common Bile Duct Closure
Journal of Nepal Medical Association, 2010 INTRODUCTION: Closure of the common bile duct over T-tube after exploration is a widely practiced traditional method. However, its use may give rise to many complications. We do primary closure of common bile duct after exploration.
M R Joshi, DR Singh
doaj +1 more source
Review of Gastrointestinal Capsule Robots: Materials, Actuation, Diagnostics, and Therapeutics
Advanced Science, EarlyView.This review examines gastrointestinal capsule robots through a systems engineering lens, covering shell materials, actuation and localization strategies, diagnostic modalities, therapeutic interventions, and commercialization status. By mapping the complete technological chain from fabrication to clinical deployment, this work identifies critical gaps ...
Zengsheng Li +8 more
wiley +1 more source
Hem-o-lok Clips Migration: An Easily Neglected Complication after Laparoscopic Biliary Surgery
Case Reports in Surgery, 2017 Clip migration into the common bile duct (CBD) is a rare but well-established phenomenon of laparoscopic biliary surgery. The mechanism and exact incidence of clip migration are both poorly understood.
Jun-wen Qu +3 more
doaj +1 more source
Advanced Science, EarlyView.IGF2BP1 promotes gemcitabine resistance in pancreatic cancer by stabilizing m6A‐modified FTH1 transcripts and protecting them in stress granules, thereby suppressing ferroptosis. Pharmacological inhibition of IGF2BP1 disrupts this protective pathway, restores ferroptotic sensitivity, and enhances gemcitabine efficacy in resistant tumors.
Ying‐Qin Zhu +10 more
wiley +1 more source
Frontiers in Surgery, 2022 ObjectiveTo investigate the effectiveness and clinical value of cholangiography in the diagnosis of bile duct stones in laparoscopic cholecystectomy.Methods200 patients who underwent laparoscopic cholecystectomy in our hospital from January 2017 to ...
Yunqing Zhao +9 more
doaj +1 more source
F7 Drives Gastric Cancer Metastasis Through Anoikis Resistance and Tumor Microenvironment Remodeling
Advanced Science, EarlyView.ABSTRACT Coagulation factor VII (F7) has been implicated in tumor progression; however, its role in gastric cancer metastasis and immune evasion remains incompletely understood. In this study, we identified F7 as a clinically relevant driver of gastric cancer.
Lei Gao +9 more
wiley +1 more source
Open Common Bile Duct Exploration in a Nigerian Tertiary Hospital
The Annals of African Surgery, 2018 Background: The prevalence of extra-hepatic biliary stones in Nigeria is unknown and its treatment frequently undocumented. We have observed an increase in bile duct exploration in our hospital.
Adewale Adisa +5 more
doaj
Advanced Science, EarlyView.The CXCL5/CXCR2 axis directly inhibits ferroptosis in ICC cells by activating the NF‐κB/PTGS2 pathway. Meanwhile, the CXCL5/CXCR2 axis recruits N2 TANs, and the activated PTGS2 promotes the secretion of TNF‐α from the recruited N2 TANs via the CCL2/CCL7/CCR2 pathway, thereby activating the NF‐κB/PTGS2 axis and forming a positive feedback loop, which ...
Chanqi Ye +17 more
wiley +1 more source