Results 1 to 10 of about 120,649 (299)

Human extrahepatic and intrahepatic cholangiocyte organoids show region-specific differentiation potential and model cystic fibrosis-related bile duct disease

Scientific Reports, 2020
The development, homeostasis, and repair of intrahepatic and extrahepatic bile ducts are thought to involve distinct mechanisms including proliferation and maturation of cholangiocyte and progenitor cells.
Monique M. A. Verstegen, Floris J. M. Roos, Ksenia Burka, Helmuth Gehart, Myrthe Jager, Maaike de Wolf, Marcel J. C. Bijvelds, Hugo R. de Jonge, Arif I. Ardisasmita, Nick A. van Huizen, Henk P. Roest, Jeroen de Jonge, Michael Koch, Francesco Pampaloni, Sabine A. Fuchs, Imre F. Schene, Theo M. Luider, Hubert P. J. van der Doef, Frank A. J. A. Bodewes, Ruben H. J. de Kleine, Bart Spee, Gert-Jan Kremers, Hans Clevers, Jan N. M. IJzermans, Edwin Cuppen, Luc J. W. van der Laan   +25 more
doaj   +2 more sources

Bioengineered Bile Duct for Liver Regenerative Medicine and Bile Duct Reconstruction [PDF]

JGH Open
Bioengineered tubular bile ducts are an emerging strategy in liver regenerative medicine and extrahepatic bile duct reconstruction, offering potential solutions to address biliary diseases and improve outcomes in liver transplantation.
Peilin Li, Di Huang, Weili Gu, Yi Gao, Yu Huang   +4 more
doaj   +2 more sources

Cholangiocyte organoids from human bile retain a local phenotype and can repopulate bile ducts in vitro

Clinical and Translational Medicine, 2021
The well‐established 3D organoid culture method enabled efficient expansion of cholangiocyte‐like cells from intrahepatic (IHBD) and extrahepatic bile duct (EHBD) tissue biopsies.
Floris J. M. Roos, Haoyu Wu, Jorke Willemse, R. Lieshout, Laura A Muñoz Albarinos, Yik Y. Kan, J. Poley, M. Bruno, J. de Jonge, R. Bártfai, H. Marks, J. Ijzermans, M. Verstegen, Luc J. W. van der Laan   +13 more
semanticscholar   +1 more source

Glucagon- and insulin-immunopositive endocrine cells in porcine extrahepatic bile ducts and gallbladder

Frontiers in Veterinary Science, 2023
IntroductionPancreatic β-cells and α-cells have been found in the murine extrahepatic biliary ducts but not in the gallbladder. However, there has been no information reported in the specialized literature about the presence of glucagon- and insulin ...
Ivaylo Stefanov Stefanov, Ivaylo Stefanov Stefanov, Stefan Ivaylov Stefanov, Maya Vladova Gulubova, Maya Vladova Gulubova   +4 more
doaj   +1 more source

Scaffolds obtained from decellularized human extrahepatic bile ducts support organoids to establish functional biliary tissue in a dish

Biotechnology and Bioengineering, 2020
Biliary disorders can lead to life‐threatening disease and are also a challenging complication of liver transplantation. As there are limited treatment options, tissue engineered bile ducts could be employed to replace or repair damaged bile ducts.
Jorke Willemse, Floris J. M. Roos, Iris J. Voogt, Ivo J. Schurink, M. Bijvelds, H. D. de Jonge, Luc J. W. van der Laan, J. de Jonge, M. Verstegen   +8 more
semanticscholar   +1 more source

Primary Extrahepatic Bile Duct Carcinoids [PDF]

HPB Surgery, 1996
Biliary tact carcinoids are extremely rare: only ten cases have been reported up to now. The Authors describe a successfully treated carcinoid tumour ofthe proximal bile duct and review the literature about these rare malignancies.Despite extensive preoperative work‐up, including ultrasound, CT scan and ERCP, a definite diagnosis is hardly possible ...
Belli, Giulio, Rotondano, Gianluca, D'Agostino, Alberto, Marano, Ines   +3 more
openaire   +2 more sources

Carcinoma of the Extrahepatic Bile Ducts [PDF]

Annals of Surgery, 1969
A A, el-Domeiri, R D, Brasfield, J L, O'Quinn   +2 more
openaire   +5 more sources

Cystic biliary anomaly in a newborn with features of choledochal cyst and cystic biliary atresia

Journal of Pediatric Surgery Case Reports, 2021
Cystic biliary atresia (CBA) and choledochal cysts (CDC) can present similarly with early onset jaundice, conjugated hyperbilirubinemia, and radiographic cystic biliary dilatations. We present the case of an infant antenatally diagnosed with a congenital
C.L. Berkowitz, A.W. Peters, J.D. Stratigis, P.D. Barone, A.V. Kadenhe-Chiweshe, P.S. Oh   +5 more
doaj   +1 more source

Treatment and prevention of hepatic failure in acute biliary pancreatitis in patients with diabetes mellitus

Mìžnarodnij Endokrinologìčnij Žurnal, 2017
Background. The purpose of the study was to evaluate the effectiveness of traditional and optimized programs for integrated treatment and prevention of clinical and laboratory manifestations of hepatic dysfunction in acute biliary pancreatitis in ...
S.I. Savoliuk, Ya.V. Tomashevsky, T.O. Melnik   +2 more
doaj   +1 more source

Features of medical tactics and its perioperative medications in acute pancreatitis of biliary etiology in diabetic patients

Mìžnarodnij Endokrinologìčnij Žurnal, 2017
The aim of the study was clinical and laboratory evaluation of the effectiveness of traditional and optimized therapeutic and diagnostic technologies in acute pancreatitis of biliary etiology in diabetic patients with diabetes mellitus.
S.I. Savoliuk, Y.V. Tomashevsky
doaj   +1 more source