Results 51 to 60 of about 120,649 (299)

A genome-wide association study identifies a susceptibility locus for biliary atresia on 2p16.1 within the gene EFEMP1 [PDF]

, 2018
Biliary atresia (BA) is a rare pediatric cholangiopathy characterized by fibrosclerosing obliteration of the extrahepatic bile ducts, leading to cholestasis, fibrosis, cirrhosis, and eventual liver failure.
Bailey-Wilson, Joan E, Chen, Ying, Devoto, Marcella, Gilbert, Melissa A, Grochowski, Christopher M, Hakonarson, Hakon, Llewellyn, Jessica, Loomes, Kathleen M, Mceldrew, Deborah, Russo, Pierre, Spinner, Nancy B, Waisbourd-Zinman, Orith, Wells, Rebecca G   +12 more
core   +2 more sources

F13A1‐Mediated Macrophage Activation Promotes MASH Progression via the PKM2/HIF1A Pathway

Advanced Science, EarlyView.
In fatty liver disease, hepatocytes exposed to palmitate release S1P, which activates calcium signaling in macrophages. Elevated calcium enhances the activity of F13A1, driving PKM2 dimerization. The PKM2 dimers cause Warburg effect, translocate to the nucleus, cooperate with HIF1A, and upregulate IL1B expression, ultimately promoting classical ...
Qianrang Lu, Meiching Ong, Xuewen Yi, Muqiong Xing, Xinyao Tian, Ke Zhang, Ling Lu, Hao Wang, Xiaohan Lin, Jun Fang, Aibo Mu, Jiaying Cao, Jingyu Jiang, Feng Gao, Hongjun Li, Baohong Wang, Qi Ling   +16 more
wiley   +1 more source

Type Va extrahepatic bile duct duplication: a case report

Journal of Medical Case Reports, 2019
Background Extrahepatic bile duct duplication is an extremely rare congenital anomaly in which two common bile ducts exist. There are five different types of this anomaly and we present an unusual variant of duplication of an extrahepatic biliary system ...
Bharat Mani Banjade, Ashish Rajbhandari, Rabin Koirala, Tuhin Shah, Chitra Lal Bhattachan   +4 more
doaj   +1 more source

Evidence for Recipient-Derived Cells in Peribiliary Glands and Biliary Epithelium of the Large Donor Bile Ducts After Liver Transplantation

Frontiers in Cell and Developmental Biology, 2020
IntroductionChimerism after orthotopic liver transplantation (OLT) has largely been investigated in intrahepatic cellular constituents. However, little is known about chimerism in the extrahepatic and large intrahepatic bile ducts.
Iris E. M. de Jong, Iris E. M. de Jong, Michael E. Sutton, Michael E. Sutton, Marius C. van den Heuvel, Annette S. H. Gouw, Robert J. Porte   +6 more
doaj   +1 more source

Choledochal cyst with a twist: Type 1 choledochal cyst and dilated cystic duct with aberrant accessory right hepatic drainage

Journal of Pediatric Surgery Case Reports, 2023
Choledochal cysts are rare cystic dilations of the biliary tree that typically involve the extrahepatic bile duct and more infrequently, the intrahepatic bile ducts. Todani's classification of choledochal cysts is the most referenced system in which five
Pia V. Sodhi, Erin Glennon, Sarah McIntyre, Shailee Lala, Laura Martin, Sandra Tomita   +5 more
doaj   +1 more source

Minimally invasive papillary carcinoma of the extrahepatic bile ducts [PDF]

, 2008
Invasive papillary carcinomas of the Extrahepatic Bile Ducts (EBD) are uncommon (4-5%). The course is less aggressive than conventional adenocarcinomas of the extrahepatic bile ducts.
Ahmad, Zubair, Fatima, Samia, Minhas, Khurram, Pal, Inam, Qureshi, Asim   +4 more
core   +1 more source

Educational Impact of Artificial Intelligence‐Navigation Surgery on Anatomical Landmark Recognition in Medical Students

Annals of Gastroenterological Surgery, EarlyView.
This study evaluated the educational impact of artificial intelligence (AI)‐navigation surgery that provides real‐time anatomical landmark recognition during laparoscopic cholecystectomy for medical students. Thirty students were randomized into surgeon‐guided, self‐learning, and AI‐learning groups, and their performance was assessed using Dice ...
Shigeo Ninomiya, Yusuke Matsunobu, Tabito Oyama, Hiroomi Takayama, Takashi Masuda, Teijiro Hirashita, Yuichi Endo, Tatsushi Tokuyasu, Masafumi Inomata   +8 more
wiley   +1 more source

The Algorithm of Treatment Tactics for Patients with Tumor Obstruction of Extrahepatic Bile Ducts

Львівський клінічний вісник, 2013
Introduction. The problem of surgical treatment of patients with tumors of the extrahepatic bile ducts is one of the most important and complicated in the surgery of the hepatopancreatoduodenal zone and is of increasing interest to the researchers.
Dutka Ya.
doaj   +1 more source

Biliary Anomalies in Patients With HNF1B Diabetes [PDF]

, 2017
Context: The clinical spectrum of organogenetic anomalies associated with HNF1B mutations is heterogeneous. Besides cystic kidney disease, diabetes, and various other manifestations, odd cases of mainly neonatal and posttransplantation cholestasis have ...
Färkkilä, Martti, Kettunen, Jarno L. T., Lantto, Eila, Miettinen, Päivi J., Parviainen, Helka, Salonen, Pia, Tamminen, Marjo, Tuomi, Tiinamaija   +7 more
core   +1 more source

Surgical Outcomes and Recurrence Management in Borderline Resectable Hepatocellular Carcinoma: Implications for Multidisciplinary Strategies

Annals of Gastroenterological Surgery, EarlyView.
Multivariate analysis identified that up‐to‐7 out (p < 0.001), lymph node metastasis (p < 0.001), and non‐anatomical resection (p = 0.02) were independent predictors of cancer recurrence, while older age (p = 0.01), Child‐Pugh B (p < 0.001), up‐to‐7 out (p = 0.01), macrovascular invasion (p = 0.01), and lymph node metastasis (p < 0.001) were ...
Koichiro Haruki, Kenei Furukawa, Munetoshi Akaoka, Yuto Yamahata, Shinji Onda, Yoshihiro Shirai, Masashi Tsunematsu, Tomohiko Taniai, Michinori Matsumoto, Toru Ikegami   +9 more
wiley   +1 more source