Results 91 to 100 of about 226,924 (326)
Biliary atresia: Potential for a new decade.
Seminars in Pediatric Surgery, 2020 Biliary atresia is characterised as an obliterative cholangiopathy of both extra-and intra-hepatic bile ducts. There is marked aetiological heterogeneity with a number of different variants, some syndromic and others perhaps virally-mediated.
F. Scottoni, M. Davenport
semanticscholar +1 more source
Rotavirus Reassortant–Induced Murine Model of Liver Fibrosis Parallels Human Biliary Atresia
Hepatology, 2020 Biliary atresia (BA) is a devastating neonatal cholangiopathy that progresses to fibrosis and end‐stage liver disease by 2 years of age. Portoenterostomy may reestablish biliary drainage, but, despite drainage, virtually all afflicted patients develop ...
S. Mohanty +14 more
semanticscholar +1 more source
The Surgery of Biliary Atresia
Annals of Surgery, 1989 One hundred thirty-one consecutive infants with biliary atresia were operated on during the 15-year period between 1973 and 1988. Six patients did not have biliary reconstruction because of advanced cirrhosis or transplant preference. The other 125 infants had excision of all nonpatent extrahepatic bile ducts; biliary drainage was provided by a ...
J R, Lilly +7 more
openaire +3 more sources
Human Cyclophilins—An Emerging Class of Drug Targets
Medicinal Research Reviews, EarlyView.ABSTRACT Cyclophilins are a family of enzymes with peptidyl‐prolyl isomerase activity found in all cells of all organisms. To date, 17 cyclophilin isoforms have been identified in the human body, participating in diverse biological processes. Consequently, cyclophilins have emerged as promising targets for drug development to address a wide array of ...
Katarina Jurkova +3 more
wiley +1 more source
Weaning of immunosuppression in long - Term liver transplant recipients [PDF]
, 1995 Seventy-two long-surviving liver transplant recipients were evaluated prospectively, including a baseline allograft biopsy for weaning off of immunosuppression.
Abu-Elmagd, K +11 more
core +1 more source
mBio, 2020 There is substantial evidence indicating the possible involvement of rotavirus in biliary atresia (BA) development, at least in a subset of patients, but concrete proof remains lacking.
Sunrui Chen +8 more
semanticscholar +1 more source
Application of machine learning in constructing a diagnostic model for neonatal biliary atresia
Pediatric Investigation, EarlyView.This study included 85 neonates who visited the hospital due to pathological jaundice. Using the basic clinical characteristics and serological examination data of the neonatal period, we developed six machine‐learning (ML) models. Extreme gradient boosting has the maximum potential to diagnose biliary atresia in the neonatal period.
Dingding Wang +11 more
wiley +1 more source
Journal of hepato-biliary-pancreatic sciences, 2020 The purpose of this study was to prepare clinical practice guidelines for biliary atresia according to the Medical Information Network Distribution Service (MINDS) Handbook for Clinical Practice Guideline Development 2014.
Hisami Ando +6 more
semanticscholar +1 more source
CPT: Pharmacometrics &Systems Pharmacology, EarlyView.ABSTRACT Pediatric extrapolation strategies issued by health authorities have streamlined pediatric drug development and reduced the unnecessary burden of conducting pediatric clinical studies. In line with these strategies, physiologically based pharmacokinetic (PBPK) models have been utilized extensively for initial dosing regimen and sampling ...
James W. T. Yates +26 more
wiley +1 more source
Hepatology, 2019 Biliary atresia (BA) is a neonatal liver disease featuring cholestasis and severe liver fibrosis (LF). Despite advances in the development of surgical treatment, lacking an early diagnostic marker and intervention of LF invariably leads to death from end‐
Yongtao Xiao +7 more
semanticscholar +1 more source