Results 111 to 120 of about 575,936 (265)

Extrapolation and pharmacokinetic protocol design optimization for ceftriaxone as an exemplar for the development of antibiotics for children

British Journal of Clinical Pharmacology, EarlyView.
Aim Ceftriaxone is a cephalosporin commonly used for the treatment of acute, severe infections; however, there are conflicting data on its disposition properties in children, making it a suitable case study for the evaluation of the appropriateness of extrapolation approaches based on exposure matching principles for paediatric patients and exploring ...
Daniel Valente Neves, Umberto Villani, Salvatore D'Agate, Sean Oosterholt, Ricardo de Carvalho Cavalli, Fabio Carmona, Vera Lucia Lanchote, Oscar Della Pasqua   +7 more
wiley   +1 more source

Bronchogenic cyst of pancreas: a rare case report

Frontiers in Surgery
BackgroundBronchogenic cyst is a rare congenital developmental abnormality of the anterior bowel. Peri-pancreatic bronchogenic cyst (PBC) is extremely rare, when only a few cases reported worldwide.
Ruiqi Zou, Yushi Dai, Fuyu Li, Fei Liu, Yixin Lin   +4 more
doaj   +1 more source

Imaging diagnosis-extrahepatic biliary tract obstruction secondary to a duodenal foreign body in a cat

, 2007
A 13-month-old, neutered female domestic shorthaired cat was evaluated for vomiting, anorexia, and lethargy. The cat was icteric and hyperbilirubinemic.
JOHANN LANG, ARIANE SCHWEIGHAUSER, Lang, Johann, Forterre, Franck, FRANCK FORTERRE, Schweighauser, Ariane, Della Santa, Daniele, DANIELE DELLA SANTA   +7 more
core   +1 more source

Regulatory harmonization: Evolution, globalization and future directions

British Journal of Clinical Pharmacology, EarlyView.
Regulatory harmonization has become an increasingly important and accepted approach to streamline regulatory review processes and expedite access to safe, effective and high‐quality medicines globally. This review explores the evolution and current status of regulatory harmonization, convergence and reliance initiatives.
Orin Chisholm, Elaine Y. L. Blair, Christine Y. Lu   +2 more
wiley   +1 more source

Aberrant promoter hypermethylation in biliary tract carcinoma

, 2006
論文(Article)Biliary tract carcinoma is a relatively rare tumor with a poor survival rate. The molecular biological mechanisms underlying the development of biliary tract carcinomas are not well understood.
Koga, Y, Kitajima, Y, Kohya, N, Miyazaki, K, 84078, 84077, 84076, 84075   +7 more
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Coledocoduodenostemia Látero-Lateral com oclusão do coto do colédoco distal para evitar a "SUMP SYNDROME". [PDF]

, 1996
Trabalho de Conclusão de Curso - Universidade Federal de Santa Catarina, Centro de Ciências da Saúde, Departamento de Clínica Cirúrgica, Curso de Medicina, Florianópolis ...
Chatagnier, Bernardo de Toledo BarDa Ros
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Tackling cancer stemness with nanotechnology in the era of precision medicine

BMEMat, EarlyView.
Precise customization of nanoparticles (NPs) enables active targeting of cancer stem cells (CSCs), thereby improving drug delivery and therapeutic efficacy. NP‐based probing enhances CSC detection through imaging and liquid biopsy, whereas diverse therapeutic payloads improve therapeutic outcomes.
Shaolei Guo, Shun Yao, Lihui Meng, Chunyuan Chen, Yuechu Lucinda Lu, Rong Lu, Kashif Rafiq Zahid, Umar Raza, Qingzhi Wu, Wenli Chen   +9 more
wiley   +1 more source

Robotic versus open pancreaticoduodenectomy in elderly patients: a meta-analysis

Frontiers in Oncology
ObjectiveWith the aging population and increasing indications for pancreatic surgery, more elderly patients are being considered for pancreaticoduodenectomy (PD).
Cuifang Zeng, Lin Xie, Jie Zhang, Gang Tang, Rongxing Zhou   +4 more
doaj   +1 more source

Controllable engineered probiotic microspheres for treating ulcerative colitis: A cascade enzyme‐catalyzed strategy to restore intestinal redox homeostasis

BMEMat, EarlyView.
A dual strategy integrating genetic engineering and physical encapsulation was proposed to enhance the cell viability and antioxidant properties of probiotics. The cascade antioxidant enzymes released from probiotic microspheres restore intestinal redox homeostasis by eliminating intestinal reactive oxygen species for ulcerative colitis treatment ...
Xiaolong Mao, Xiangwei Lv, Miaomiao Zhang, Jiayi Liu, Yun Chen, Yunna Li, Gaoyuan Liu, Fuming Yang, Ziqiang Han, Yunyun Wei   +9 more
wiley   +1 more source

A Case of Magnetic Compression Anastomosis in Benign Ischemic Biliary Stricture from Hepatic Artery Embolization to Control Hemorrhage due to Liver Laceration [PDF]

, 2013
Percutaneous and endoscopic interventions are treatments of choice in benign biliary stricture, while lesions with complete obstructions or with acute angulations may require surgical management.
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