Results 111 to 120 of about 608,465 (311)

Extrapolation and pharmacokinetic protocol design optimization for ceftriaxone as an exemplar for the development of antibiotics for children

British Journal of Clinical Pharmacology, EarlyView.
Aim Ceftriaxone is a cephalosporin commonly used for the treatment of acute, severe infections; however, there are conflicting data on its disposition properties in children, making it a suitable case study for the evaluation of the appropriateness of extrapolation approaches based on exposure matching principles for paediatric patients and exploring ...
Daniel Valente Neves, Umberto Villani, Salvatore D'Agate, Sean Oosterholt, Ricardo de Carvalho Cavalli, Fabio Carmona, Vera Lucia Lanchote, Oscar Della Pasqua   +7 more
wiley   +1 more source

[Histological sectioning of brush bristles allows an improved diagnosis of biliary tract lesions].

, 2007
Biliary tract brush cytology is increasingly being recognized as a favoured method for evaluating abnormalities of the biliary tract. In order to increase the diagnostic accuracy, we devise a new brush processing method finalized to the complete and ...
ASIOLI, SOFIA, Accinelli G, Bussolati G.
core   +1 more source

Case Report: First case of percutaneous transhepatic cholangioscopy guided triple bridge drainage between multiple bile ducts for malignant hilar biliary obstruction

Frontiers in Oncology
BackgroundBiliary drainage for advanced malignant hilar biliary obstruction (MHBO) remains a significant challenge in current clinical practice.Case descriptionA 58-year-old male diagnosed with unresectable advanced intrahepatic cholangiocarcinoma with ...
Gang Tang, Jie Zhang, Rui Chen, Jingyi Zhang, Rongxing Zhou   +4 more
doaj   +1 more source

Regulatory harmonization: Evolution, globalization and future directions

British Journal of Clinical Pharmacology, EarlyView.
Regulatory harmonization has become an increasingly important and accepted approach to streamline regulatory review processes and expedite access to safe, effective and high‐quality medicines globally. This review explores the evolution and current status of regulatory harmonization, convergence and reliance initiatives.
Orin Chisholm, Elaine Y. L. Blair, Christine Y. Lu   +2 more
wiley   +1 more source

C2ORF68 stabilizes SIVA1 to upregulate BCL-2 and suppress apoptosis in gallbladder cancer

Cell Death Discovery
Gallbladder cancer (GBC) is the most aggressive malignancy of the biliary tract, and its molecular drivers remain insufficiently understood. SIVA1 (apoptosis regulatory protein Siva 1) has been implicated in the regulation of cell survival, but its ...
Xuanjia Dong, Lingxiao Zhang, Wenjun Dong, Qiuyi Tang, Jingwei Zhao, Zhaohui Jin, Lin Jiang, Wenting Dai, Yangyang Zhai, Ying Huang   +9 more
doaj   +1 more source

Recurrent hepatocellular carcinoma treated by laparoscopic non-anatomical liver resection via the retroperitoneal approach: a case report

Frontiers in Surgery
BackgroundRepeat laparoscopic hepatic resection is an important treatment for recurrent hepatocellular carcinoma. However, intra-abdominal adhesions from prior open surgery and poor exposure of posterior segment lesions significantly increase surgical ...
Kecheng Zhang, Yang Liu, Bing Liu, Ruiliang Ge   +3 more
doaj   +1 more source

Surgical anatomy of the biliary tract

, 2015
An accurate knowledge of intra-hepatic bile duct ramifications and their variations, as well as the variations in the confluence of the hepatic ducts and their branches, is of crucial importance for hepato-biliary surgeons. Lack of knowledge in this area
CUCCHETTI, ALESSANDRO, MAZZOTTI, FEDERICO   +1 more
core  

Tackling cancer stemness with nanotechnology in the era of precision medicine

BMEMat, EarlyView.
Precise customization of nanoparticles (NPs) enables active targeting of cancer stem cells (CSCs), thereby improving drug delivery and therapeutic efficacy. NP‐based probing enhances CSC detection through imaging and liquid biopsy, whereas diverse therapeutic payloads improve therapeutic outcomes.
Shaolei Guo, Shun Yao, Lihui Meng, Chunyuan Chen, Yuechu Lucinda Lu, Rong Lu, Kashif Rafiq Zahid, Umar Raza, Qingzhi Wu, Wenli Chen   +9 more
wiley   +1 more source

Malignant Neoplasia of the Extrahepatic Biliary Tract

, 1922
University of Minnesota Masters thesis. April 1922. Major: Surgery. 1 computer file (PDF); 64 pages.Renshaw, Kinsley. (1922). Malignant Neoplasia of the Extrahepatic Biliary Tract. Retrieved from the University Digital Conservancy, https://hdl.handle.net/
Renshaw, Kinsley
core  

Controllable engineered probiotic microspheres for treating ulcerative colitis: A cascade enzyme‐catalyzed strategy to restore intestinal redox homeostasis

BMEMat, EarlyView.
A dual strategy integrating genetic engineering and physical encapsulation was proposed to enhance the cell viability and antioxidant properties of probiotics. The cascade antioxidant enzymes released from probiotic microspheres restore intestinal redox homeostasis by eliminating intestinal reactive oxygen species for ulcerative colitis treatment ...
Xiaolong Mao, Xiangwei Lv, Miaomiao Zhang, Jiayi Liu, Yun Chen, Yunna Li, Gaoyuan Liu, Fuming Yang, Ziqiang Han, Yunyun Wei   +9 more
wiley   +1 more source