Results 71 to 80 of about 83,082 (294)

Genetic predisposition to porto‐sinusoidal vascular disorder: A functional genomic‐based, multigenerational family study

Hepatology, EarlyView., 2022
A deleterious variant of FCHSD1 results in mTOR pathway overactivation and may cause porto‐sinusoidal vascular disorder (PSVD). The pedigree of the family demonstrated an autosomal dominant disease with variable expressivity. Whole‐genome sequencing and Sanger sequencing both validated the existence of the FCHSD1 variant and the heterozygosity of c ...
Jingxuan Shan, André Megarbane, Aziz Chouchane, Deepak Karthik, Ramzi Temanni, Atilio Reyes Romero, Huiying Hua, Chun Pan, Xixi Chen, Murugan Subramanian, Chadi Saad, Hamdi Mbarek, Cybel Mehawej, Eliane Chouery, Sirin W. Abuaqel, Alexander Dömling, Sami Remadi, Cesar Yaghi, Pu Li, Lotfi Chouchane   +19 more
wiley   +1 more source

Review of the anatomical basis for predicting plutonium alpha particle radiation induced osteogenic cancers

The Anatomical Record, EarlyView.
Abstract Plutonium was discovered and first synthesized in the early 1940's. Several isotopes of plutonium are used in nuclear technologies, 238Pu for heat generation and 239Pu for energy production and weapons. Both isotopes emit alpha particles, which pose a significant radiation hazard when incorporated into the body.
Scott C. Miller
wiley   +1 more source

Fasting-induced RNF152 resensitizes gallbladder cancer cells to gemcitabine by inhibiting mTORC1-mediated glycolysis

iScience
Summary: Abnormal mTORC1 activation by the lysosomal Ragulator complex has been implicated in cancer and glycolytic metabolism associated with drug resistance. Fasting upregulates RNF152 and mediates the metabolic status of cells.
Ying Tao, Zijun Gong, Sheng Shen, Yaqi Ding, Rui Zan, Bohao Zheng, Wentao Sun, Chaolin Ma, Mengxuan Shu, Xiao Lu, Han Liu, Xiaoling Ni, Houbao Liu, Tao Suo   +13 more
doaj  

The footprint of gut microbiota in gallbladder cancer: a mechanistic review

Frontiers in Cellular and Infection Microbiology
Gallbladder cancer (GBC) is the most common malignant tumor of the biliary system with the worst prognosis. Even after radical surgery, the majority of patients with GBC have difficulty achieving a clinical cure. The risk of tumor recurrence remains more
Shujie Liu, Weijian Li, Weijian Li, Weijian Li, Weijian Li, Jun Chen, Jun Chen, Jun Chen, Jun Chen, Maolan Li, Maolan Li, Maolan Li, Maolan Li, Yajun Geng, Yajun Geng, Yajun Geng, Yajun Geng, Yingbin Liu, Yingbin Liu, Yingbin Liu, Yingbin Liu, Wenguang Wu, Wenguang Wu, Wenguang Wu, Wenguang Wu   +24 more
doaj   +1 more source

Dietary Baicalin Supplementation Can Enhance the Growth Performance of Weaned Piglets and Maintain the Intestinal Barrier Integrity

Animal Research and One Health, EarlyView.
This research innovatively illustrates baicalin’s multifaceted mechanisms in enhancing piglets’ intestinal health: modulating bile acid metabolism via probiotics, reinforcing tight junction proteins (ZO‐1/claudin), suppressing TLR4/NF‐κB‐mediated inflammation, whereas promoting growth and reducing diarrhea.
Yuhui Gao, Jie Liu, Rui Yang, Xizhen Fan, Cheng Liang, Xin'e Shi, Jianjun Jin   +6 more
wiley   +1 more source

Multi‐Omics Insights Into the Role of Fructooligosaccharides Supplementation in Alleviating Salpingitis in Laying Hens

Animal Research and One Health, EarlyView.
Multi‐omics analysis revealed that FOS supplementation increased the abundance of Phascolarctobacterium, GCA‐900066575, Shuttleworthia, Olsenella, Eubacterium_hallii_group while decreasing Alistipes. It also influenced the metabolism of S‐lactoylglutathione, p‐cresol glucuronate, 2‐phenylethanol glucuronide, propionic acid, dulcitol, and inhibited the ...
Dan Song, Tao Duan, Rong Li, Xiaoqiu Wang, Fengdong Zhang, Jia Feng, Lin Qiao, Junlin Cheng, Lixian Chen, Aike Li, Yuna Min, Weiwei Wang   +11 more
wiley   +1 more source

Effects of Dietary Protein Level on Growth Performance, Serum Biochemistry, Intestinal Morphology, and Intestinal Microbiota in Ningxiang Finishing Pigs

Animal Research and One Health, EarlyView.
A low‐protein (LP) diet maintained growth performance while enhancing colonic microbiota composition and nitrogen utilization in Ningxiang finishing pigs. These findings enhance our understanding of protein nutrition in indigenous fat‐type pig breeds and provide a theoretical foundation for optimizing dietary formulations in Ningxiang pigs.
Xianglin Zeng, Wenzhi Liu, Zhaobin Wang, Kai Yang, Qiye Wang, Huansheng Yang   +5 more
wiley   +1 more source

Research hotspots and trends of biodegradable magnesium and its alloys

Smart Materials in Medicine, 2023
With the increasing demand for innovative therapies, biodegradable magnesium has attracted more and more attention, which could avoid secondary surgery and reduce complications. Until now, plenty of researchers take part in the research & development
Rui Zan, Sheng Shen, Yuanding Huang, Han Yu, Yaohui Liu, Shi Yang, Bohao Zheng, Zijun Gong, Wenhui Wang, Xiaonong Zhang, Tao Suo, Houbao Liu   +11 more
doaj  

Dietary supplement of sodium butyrate improves the growth performance and intestinal health by targeting Wnt/β‐catenin signaling pathway in rabbits

Animal Research and One Health, EarlyView.
Dietary supplement of sodium butyrate, may relate to regulating intestinal health and thus the growth performance and meat quality of rabbits by regulating the continuous process of promoting the periodic cycle of cecal epithelial cells. Abstract Supplementation of sodium butyrate (SB) has been proved to be beneficial for improving the growth ...
Mengke Ni, Zhitong Wang, Zhichao Li, Mengjuan Chen, Hui He, Hanfang Cai, Zhi Chen, Ming Li, Huifen Xu   +8 more
wiley   +1 more source

Plants, plant‐derived compounds, probiotics, and postbiotics as green agents to fight against poultry coccidiosis: A review

Animal Research and One Health, EarlyView.
Therapeutic effect of natural products on chicken coccidiosis. Abstract The intestinal tract is the main place for animals to digest food and absorb nutrients, which also serves as the first line of defense against pathogens that invade the internal environment.
Pan Chen, Kaili Liu, Taojing Yue, Yanan Lu, Senyang Li, Fuchun Jian, Shucheng Huang   +6 more
wiley   +1 more source