Results 101 to 110 of about 595,039 (309)

Porphyria cutanea tarda increases risk of hepatocellular carcinoma and premature death: a nationwide cohort study

Orphanet Journal of Rare Diseases, 2019
Background Porphyria cutanea tarda (PCT) is a skin disorder originating from a deficit of the liver enzyme uroporphyrinogen decarboxylase. PCT may be a risk factor for hepatocellular carcinoma (HCC) and other cancers, but the evidence is unclear.
Carl Michael Baravelli, Sverre Sandberg, Aasne Karine Aarsand, Mette Christophersen Tollånes   +3 more
doaj   +1 more source

Malignant Biliary Tract Obstruction: Evaluation and Therapy

, 2010
Malignant biliary tract obstruction is a common clinical entity. Patients with tumors causing biliary tract obstruction are often asymptomatic until disease is significantly advanced.
Douglas G. Adler, David Chu
core   +1 more source

Utilization of immune checkpoint inhibitors for the treatment of cancer in Scotland, 2018–2024: A national retrospective cohort study

British Journal of Clinical Pharmacology, EarlyView.
Aims The aim of the study is to describe the use of immune checkpoint inhibitors (ICIs) for the treatment of cancer in Scotland. Methods The retrospective observational cohort study included patients aged 18 years or older who commenced treatment with an ICI in Scotland between 1 January 2018 and 31 December 2024.
Tanja Mueller, Christine Crearie, Liya Lu, Jiafeng Pan, Fraser N. Sneden, David Martin, Amanj Kurdi, Catherine S. Thomson, Julie Clarke, Marion Bennie   +9 more
wiley   +1 more source

Biliary Tract Cancer

, 2017
Biliary tract cancers encompass tumors of the gallbladder, extrahepatic bile ducts, and ampulla of Vater. In the United States, biliary tract cancer is the fifth most common malignant neoplasm of the digestive tract, accounting for about 3,700 deaths per
Jill Koshiol, Joseph F. Fraumeni, Catterina Ferreccio, Susan S. Devesa, Juan Carlos Roa   +4 more
core   +1 more source

In-hospital mortality after resection of biliary tract cancer in the United States [PDF]

, 2010
ObjectiveTo assess perioperative mortality following resection of biliary tract cancer within the U.S.BackgroundResection remains the only curative treatment for biliary tract cancer. However, current data on operative mortality after surgical resections
McPhee, James T., Tseng, Jennifer F., Sing Chau Ng, Shah, Shimul A., James T. McPhee, Shimul A. Shah, Carroll, James E. Jr., Carroll Jr, James E., Hurwitz, Zachary M., Zachary M. Hurwitz, James E. Carroll Jr, Jessica P. Simons, Simons, Jessica P., Ng, Sing Chau, Al-Refaie, Waddah B., Jennifer F. Tseng, Waddah B. Al-Refaie   +16 more
core   +1 more source

Regulatory harmonization: Evolution, globalization and future directions

British Journal of Clinical Pharmacology, EarlyView.
Regulatory harmonization has become an increasingly important and accepted approach to streamline regulatory review processes and expedite access to safe, effective and high‐quality medicines globally. This review explores the evolution and current status of regulatory harmonization, convergence and reliance initiatives.
Orin Chisholm, Elaine Y. L. Blair, Christine Y. Lu   +2 more
wiley   +1 more source

[Surgical treatment of biliary tract neoplasms].

Wiadomosci lekarskie (Warsaw, Poland : 1960), 1998
The authors present their own experiences concerning the treatment of the 34 patients with the benign and malignant tumors of the biliary tract. In the group of patients with malignant tumors, the type and extent of the surgery were dictated by the stage of the disease.
W, Patkowski, M, Krawczyk, K, Zieniewicz, P, Nyckowski, J, Pawlak, A, Karwowski   +5 more
openaire   +1 more source

Double blind controlled trial of D-penicillamine in patients with primary biliary cirrhosis. [PDF]

, 1985
One hundred and eighty nine patients with primary biliary cirrhosis were entered into a double blind, placebo controlled randomised trial starting in January 1978 to assess the therapeutic value of d-penicillamine 1200 mg daily.
Tygstrup, Niels, Williams, Roger, Rodés, J., Ranek, L., Neuberger, J., Christensen, E., Caballeria Rovira, Joan, Portmann, B.   +7 more
core   +1 more source

Vacancy defect‐induced electron homing breaks phosphodiester bonds for RNA depletion‐driven cancer therapy

BMEMat, EarlyView.
Illustration of 5% S‐vacancy Bi2S3 mediated phosphodiester bonds cleavage in RNA of hepatocellular carcinoma cells, which suppressing ERI3 expression, inhibiting cell proliferation and promoting apoptosis. Abstract Genome‐wide hypertranscription is a hallmark of malignant progression.
Chuncheng Yang, Zehao Shen, Guangming Xiang, Zhe Liu, Huaxin Liu, Jiabei Li, Ao Wang, Yelin Wu, Peiran Zhao, Xingwu Jiang, Jinghan Wang, Xiaoqing Jiang, Wenbo Bu   +12 more
wiley   +1 more source

Mixed squamous – neuroendocrine carcinoma of the gallbladder: A case report of a rare pathological entity

Cancer Research, Statistics, and Treatment
Gallbladder cancers are the most common biliary tract malignancies in the world. Adenocarcinoma constitutes the most common histology in gallbladder cancer.
Rohik Anjum T. Siddeek, Amit Gupta, Krishna Bhukya Sai, Edem Sanketh, Deepak Rajput, Sweety Gupta, Ravi Hari Phulware   +6 more
doaj   +1 more source