Results 11 to 20 of about 6,121 (183)

Efficacy and Safety of Pharmacological, Endoscopic, and Surgical Treatments for Obesity: A GRADE-Based Network Meta-Analysis. [PDF]

Obesity (Silver Spring)
ABSTRACT Objective This review compared antiobesity strategies—obesity management medications (OMM), endoscopic bariatric procedures (EBP), and metabolic bariatric surgery (MBS)—with lifestyle intervention, placebo, or no therapy (LSI/Pbo/NT). Methods This network meta‐analysis included randomized clinical trials comparing OMM, EBP, and MBS versus LSI ...
De Luca M, Cohen RV, Belluzzi A, Navarra G, Di Lorenzo N, Petry TBZ, Sbraccia P, Busetto L, Buscemi S, Barazzoni R, Ragghianti B, Mannucci E, Monami M.   +12 more
europepmc   +2 more sources

A surgical model of short bowel syndrome induces a long-lasting increase in pancreatic beta-cell mass [PDF]

, 2015
Several surgical techniques are used nowadays as a severe treatment for obesity and diabetes mellitus type 2. These techniques are aggressive due to drastic changes in the nutrient flow and non-reversible modifications on the digestive tube.
Aguilar Diosdado, Manuel, Camacho Ramírez, Alonso, Lechuga Sancho, Alfonso María, Prada Oliveira, José Arturo, Pérez Arana, Gonzalo Martín, Sancho Maraver, Eva, Segundo Iglesias, María del Carmen   +6 more
core   +2 more sources

Can medical therapy mimic the clinical efficacy or physiological effects of bariatric surgery? [PDF]

, 2013
The number of bariatric surgical procedures performed has increased dramatically. This review discusses the clinical and physiological changes, and in particular, the mechanisms behind weight loss and glycaemic improvements, observed following the ...
le Roux, CW, Miras, AD
core   +1 more source

Comparative Efficacy of Metabolic/Bariatric Surgery Versus GLP‐1 Receptor Agonists: A Network Meta‐Analysis of Randomized Controlled Trials

Obesity, EarlyView.
ABSTRACT Objective This study compared the efficacy of metabolic/bariatric surgery (MBS) and GLP‐1 receptor agonists (GLP‐1 RAs), including dual GLP‐1/GIP analogues, for weight and metabolic outcomes in adults with obesity. Methods A network meta‐analysis of randomized controlled trials compared MBS or GLP‐1 RAs versus lifestyle intervention in adults ...
Lucas Sabatella, Patricia M. Ortega, Víctor Valentí Azcárate, Fernando Rotellar Sastre, Adriana Uriz Pagola, Ahmed Ahmed, Sanjay Purkayastha, Carlota Tuero Ojanguren, Nuria Blanco Asensio, Manuel F. Landecho   +9 more
wiley   +1 more source

Bariatric Surgery Prior to Hip and Knee Arthroplasty: A Systematic Review and Meta‐Analysis of Postoperative Outcomes

ANZ Journal of Surgery, EarlyView.
ABSTRACT Background Obesity is a major risk factor for perioperative complications following total joint arthroplasty (TJA). Bariatric surgery has been proposed to reduce these risks, but previous studies report inconsistent findings. The effect of bariatric surgery before arthroplasty remains uncertain.
Mohammad Faraz, Saiuj Bhat, Safa Gufran, Nicholas Calvert   +3 more
wiley   +1 more source

Is AMP‐activated protein kinase activation a central mechanism of cardio‐metabolic outcomes after metabolic and bariatric surgery?

Diabetes, Obesity and Metabolism, EarlyView.
Abstract Metabolic and bariatric surgery (MBS) is the most effective treatment for severe obesity. It usually results in spectacular weight loss, associated with improvements of obesity‐associated comorbidities. The mechanisms underlying these benefits are not fully understood but could involve a postoperative activation of the enzyme 5′ AMP‐activated ...
Adrien Delcour, Nathalie Niederhoffer
wiley   +1 more source

Ophthalmic Complications of Bariatric Surgery [PDF]

, 2014
Obesity is increasing vastly in the world, and the number of bariatric surgeries being performed is also increasing. Patients being submitted to bariatric surgeries, especially malabsorptive procedures, have an increased risk of developing nutrient ...
A Serra, A Sommer, A Sommer, BA Swinburn, CR Parrish, EH Harrison, EJ DeMaria, GH Slater, GV Chaves, H Sun, L Aills, M Hatizifotis, N Scopinaro, P Angulo, P Shankar, RA Sawaya, RH Clements, RM Smets, RT Naismith, Rui Azevedo Guerreiro, Rui Ribeiro, S Ledoux, S Pee de, SA Tanumihardjo, SL Pineles, SL Robbins, SR Jaiser, VL Gloy, WB Lee, WJ Pories, World Health Organization, Y Spits   +31 more
core   +1 more source

Transforming Treatment: The Impact of Bariatric Surgery on Oral Drug Absorption

Obesity Reviews, Volume 27, Issue 4, April 2026.
ABSTRACT Obesity represents a significant threat to global public health, with an estimated 16% of adults worldwide (2022) being classified as people with obesity, with a body mass index of 30 or more. Bariatric surgery is regarded as the most effective treatment option for people with obesity, with the three main types of bariatric surgery being ...
Danielle Wigg, Andrea Edginton, Matthew D. Jones, Nikoletta Fotaki   +3 more
wiley   +1 more source

Changes in Plasma Sphingolipid Metabolites Following Roux‐En‐Y Gastric Bypass in Women With Obesity and Type 2 Diabetes: A Pilot Metabolomic Cohort Study

Lipids, Volume 61, Issue 2, Page 195-205, March 2026.
ABSTRACT Although sphingolipids are key players in lipotoxicity and metabolic diseases, their response to bariatric surgery and their relation to metabolic improvement remain unclear. This pilot study investigated plasma sphingolipid remodeling after Roux‐en‐Y gastric bypass (RYGB) and its associations with clinical and biochemical markers of ...
Gabriela de Oliveira Lemos, Raquel Susana Torrinhas, Natasha Mendonça Machado, Dan Linetzky Waitzberg   +3 more
wiley   +1 more source

Bariatric surgery is accompanied by changes in extracellular vesicle-associated and plasma Fatty Acid Binding Protein 4 [PDF]

, 2017
BACKGROUND: Bariatric surgery markedly reduces fat mass with beneficial effects on cardiometabolic health but the mechanisms involved are not fully understood. Extracellular vesicles (EVs) are secreted by a variety of cells, including adipocytes, and
James, Philip, Min, Thinzar, Prior, Sarah L., Rees, Aled, Stephens, Jeffrey W., Witczak, Justyna   +5 more
core   +4 more sources