Results 131 to 139 of about 455 (139)

Bilobetin attenuates Staphylococcus aureus virulence by targeting Von Willebrand factor-binding protein and staphylocoagulase

World Journal of Microbiology and Biotechnology, 2023
Staphylococcus aureus (S. aureus) induces a variety of infectious diseases in humans and animals and is responsible for hospital- and community-acquired infections. The aim of this study was to investigate how bilobetin, a natural compound, attenuates S.
Chunjie Hu, Mengli Jin, Wu Song
exaly   +3 more sources

Quantitative determination of bilobetin in rat plasma by HPLC–MS/MS and its application to a pharmacokinetic study

Biomedical Chromatography, 2020
AbstractAlthough bilobetin, a biflavone isolated from the leaves of Ginkgo biloba, represents a variety of pharmacological activities, to date there have been no validated determination methods for bilobetin in biological samples. Thus, we developed a liquid chromatographic method using a tandem mass spectrometry for the determination of bilobetin in ...
Wonku Kang
exaly   +3 more sources

Bilobetin induces kidney injury by influencing cGMP-mediated AQP-2 trafficking and podocyte cell cycle arrest

Phytomedicine, 2019
Ginkgo biloba (Gb) extracts have been used as a traditional Chinese medicine. Gb contains flavonoids, which are considered to be its active ingredients and have been used in the treatment of a variety of diseases. However, few scientific research studies on the side effects of flavonoid in Gb have been reported.The present study aimed to investigate ...
Hong Xin
exaly   +3 more sources

Identification of bilobetin metabolites, in vivo and in vitro, based on an efficient ultra‐high‐performance liquid chromatography coupled with quadrupole time‐of‐flight mass spectrometry strategy

Journal of Separation Science, 2020
AbstractBilobetin, a natural compound extracted from Ginkgo biloba, has various pharmacological activities such as antioxidation, anticancer, antibacterial, antifungal, anti‐inflammatory, antiviral, and promoting osteoblast differentiation. However, few studies have been conducted and there are no reports on its metabolites owing to its low content in ...
Xue Feng, Luya Li, Lantong Zhang
exaly   +3 more sources

Pharmacotherapeutic potential of bilobetin to combat chromium induced hepatotoxicity via regulating TLR-4, Nrf-2/Keap-1, JAK1/STAT3 and NF-κB pathway: A pharmacokinetic and molecular dynamic approach

Journal of Trace Elements in Medicine and Biology
Chromium (Cr) is one of the top-notch noxious heavy metals that is documented to exert deleterious effects on various body organs including the liver. Bilobetin (BLB) is a natural flavonoid which exhibits a wide range of medicinal properties.This trial was executed to investigate the pharmacotherapeutic potential of BLB to avert Cr instigated ...
Mahmoud El Safadi, Muhammad Faisal Hayat, Fuad M Alzahrani   +2 more
exaly   +3 more sources

Bilobetin Shows Immunomodulatory and Chemopreventive Activities in Benzo(a)pyrene-Induced Lung Cancer in Mice Model

Indian Journal of Pharmaceutical Education and Research
Zhenjie Xu, Lihuan Zhu, Shentao Wang
exaly   +2 more sources

Bilobetin Mitigates Osteoporosis in Ovariectomy-Induced Rats by Modulating Bone Remodeling Markers, RANKL/ OPG, and NF-κB/SIRT1 Pathways

Indian Journal of Pharmaceutical Education and Research
Haifei Zhang, Kai Li
exaly   +2 more sources

Bilobetin, a novel small molecule inhibitor targeting influenza virus polymerase acidic (PA) endonuclease was screened from plant extracts

Natural Product Research, 2021
Jinrui Zhang, Ye Wang
exaly  

Biflavonoids: Important Contributions to the Health Benefits of Ginkgo (Ginkgo biloba L.)

Plants, 2022
Dunja Samec, Erna Karalija, Sabina Dahija   +2 more
exaly