Results 91 to 100 of about 294,501 (380)

Involvement of the JNK/FOXO3a/Bim Pathway in Neuronal Apoptosis after Hypoxic-Ischemic Brain Damage in Neonatal Rats. [PDF]

, 2015
c-Jun N-terminal kinase (JNK) plays a key role in the regulation of neuronal apoptosis. Previous studies have revealed that forkhead transcription factor (FOXO3a) is a critical effector of JNK-mediated tumor suppression.
Li, Deyuan, Li, Jinhui, Li, Xihong, Mu, Dezhi, Qu, Yi, Tang, Jun, Wu, Jinlin, Xiong, Tao, Zhang, Li   +8 more
core   +2 more sources

DualPG‐DTA: A Large Language Model‐Powered Graph Neural Network Framework for Enhanced Drug‐Target Affinity Prediction and Discovery of Novel CDK9 Inhibitors Exhibiting in Vivo Anti‐Leukemia Activity

Advanced Science, EarlyView.
This study introduces DualPG‐DTA, a framework integrating two pre‐trained models to generate molecular and protein representations. It constructs dual graphs processed by specialized neural networks with dynamic attention for feature fusion, achieving superior benchmark performance.
Yihao Chen, Jindi Huang, Cong Liu, Shipeng Zhang, Xinze Li, Zhang Zhang, Tie‐Gen Chen, Ling Wang   +7 more
wiley   +1 more source

Prototyping a Chatbot for Site Managers Using Building Information Modeling (BIM) and Natural Language Understanding (NLU) Techniques [PDF]

, 2023
Will Y. Lin
openalex   +1 more source

THE ANALYSIS OF BARRIERS TO BIM IMPLEMENTATION FOR INDUSTRIALIZED BUILDING CONSTRUCTION: A CHINA STUDY

, 2021
The emerging Building Information Modeling (BIM) can better promote the development of building industrialization, with data integration between information-rich building models and business processes.
Ping Wu, R. Jin, Yidong Xu, Fengjian Lin, Yiting Dong, Z. Pan   +5 more
semanticscholar   +1 more source

Investigating Approaches of Integrating BIM, IoT, and Facility Management for Renovating Existing Buildings: A Review

Sustainability, 2021
The importance of building information is highly attached to the ability of conventional storing to provide professional analysis. The Internet of Things (IoT) and smart devices offer a vast amount of live data stored in heterogeneous repositories, and ...
Abubaker Basheer Abdalwhab Altohami, N. A. Haron, T. Law   +2 more
semanticscholar   +1 more source

T Cell Exhaustion in Cancer Immunotherapy: Heterogeneity, Mechanisms, and Therapeutic Opportunities

Advanced Science, EarlyView.
T cell exhaustion limits immunotherapy efficacy. This article delineates its progression from stem‐like to terminally exhausted states, governed by persistent antigen, transcription factors, epigenetics, and metabolism. It maps the exhaustion landscape in the TME and proposes integrated reversal strategies, providing a translational roadmap to overcome
Yang Yu, Xiaoyu Yao, Qingyang Wang, Mengrui Yang, Runze Li, Jiangjiang Qin, Jing Zhuang, Changgang Sun   +7 more
wiley   +1 more source

Comparison of Single-Camera-Based Depth Estimation Technology for Digital Twin Model Synchronization of Underground Utility Tunnels

Applied Sciences, 2023
Digital twin technology can be used for disaster safety management of underground utility tunnels, which are social infrastructures. To verify its efficiency in an underground utility tunnel, it must be implemented and monitored in the real world ...
Sangmi Park, Changhee Hong, Inkyu Hwang, Jaewook Lee   +3 more
doaj   +1 more source

Problem-based learning: enhancing students learning of building information modelling [PDF]

, 2018
Building Information Modelling (BIM) is an innovative collaborative process underpinned by digital technologies introduced to improve project performance in the Architecture, Engineering and Construction (AEC) industry.
Chukwudi, Obi, Moses, Tochukwu, Obi, Lovelin   +2 more
core  

Developing Project Managers’ Transversal Competences Using Building Information Modeling [PDF]

, 2019
The emergence of building information modeling (BIM) methodology requires the training of professionals with both specific and transversal skills. In this paper, a project-based learning experience carried out in the context of a project management ...
García Sanz-Calcedo, Justo, Martínez Sánchez-Cortés, Mercedes, Reyes-Rodríguez, Antonio Manuel, Zamora-Polo, Francisco   +3 more
core   +1 more source

Adopting Building Information Modeling (BIM) for the Development of Smart Buildings: A Review of Enabling Applications and Challenges

, 2021
The construction industry is undergoing a digital revolution due to the emergence of new technologies. A significant trend is that construction projects have been transformed and upgraded to the digital and smart mode in the whole life cycle.
A. Yang, Mingzhe Han, Qingcheng Zeng, Yuhui Sun   +3 more
semanticscholar   +1 more source