Results 141 to 150 of about 64,524 (287)
Temporal Profiles of the Subcellular Localization of Bim, a BH3-Only Protein, during Middle Cerebral Artery Occlusion in Mice [PDF]
, 2002 Mamoru Shibata +5 more
openalex +1 more source
Deciphering Novel Communication Patterns in T Regulatory Cells From Very Old Adults
Aging Cell, EarlyView.Graphical summary depicting the changes in the co‐receptor landscape (a), migratory potential (b), differentiation program (c) and communication networks (d) in Tregs from the ‐< 66‐year‐old cohort versus the 85‐year‐olds. ABSTRACT Regulatory T cells (Tregs) are important in maintaining tolerance and are key players in immunity.
Tegan McTaggart +11 more
wiley +1 more source
An optimised Bcl‐3 inhibitor for melanoma treatment
British Journal of Pharmacology, EarlyView.Abstract Background and Purpose Malignant melanoma is the most lethal form of skin cancer, characterised by a poor survival rate. One of the key factors driving the aggressive growth of melanoma cells is the elevated expression of the proto‐oncogene Bcl‐3. This study aims to optimise, evaluate and characterise a second‐generation Bcl‐3 inhibitor, using
Karunakar Saamarthy +8 more
wiley +1 more source
Cancer Science, EarlyView.The combination of the Aurora‐A kinase inhibitor MLN8237 and the BH3 mimetic ABT263 enhanced anti‐tumor immunity by boosting CD8+ T cells and natural killer cells, while reducing immunosuppressive cells in the tumor microenvironment. It induced apoptosis via extrinsic and intrinsic pathways with minimal toxicity, offering a promising therapeutic ...
Mingxue Liu +4 more
wiley +1 more source
Loss of the Pro-Apoptotic BH3-only Bcl-2 Family Member Bim Inhibits BCR Stimulation–induced Apoptosis and Deletion of Autoreactive B Cells [PDF]
, 2003 Anselm Enders +5 more
openalex +1 more source
FOXO transcription factors directly activate bim gene expression and promote apoptosis in sympathetic neurons [PDF]
, 2003 Jonathan Gilley +2 more
openalex +1 more source
Mesenchymal Stem Cell‐Derived Exosomes: A Promising Therapeutic Strategy for Age‐Related Diseases
Cell Proliferation, EarlyView.Mechanisms of MSC‐Exos in the treatment of age‐related diseases. A Immunomodulatory and anti‐inflammatory, MSC‐Exos mediate immunomodulatory and anti‐inflammatory effects by regulating the polarisation of T cells and macrophages, promoting an anti‐inflammatory state while inhibiting pro‐inflammatory responses; B Suppression of oxidative stress, MSC ...
Bohua Wei +5 more
wiley +1 more source
Early developmental trajectories of the impaired hand in infants with unilateral cerebral palsy
Developmental Medicine &Child Neurology, EarlyView.Plain language summary: https://onlinelibrary.wiley.com/doi/10.1111/dmcn.16266 Abstract Aim To identify developmental trajectories of impaired hand function in infants aged 3 to 15 months with unilateral cerebral palsy (CP). Method Sixty‐three infants (37 male; median gestational age 37 weeks [interquartile range 30–39.1 weeks]) recruited as part of a ...
Leanne Sakzewski +8 more
wiley +1 more source