Results 181 to 190 of about 294,501 (380)
A Study on the Application of BIM in Civil Engineering Professional Practice [PDF]
, 2015 Zhengya ZHANG, K.M. Liu
openalex +1 more source
Clinical Genetics, EarlyView.Whole‐exome sequencing of five families with non‐medullary thyroid cancer revealed three candidate genes. Functional analyses confirmed BCL2L11 as a strong candidate gene for hereditary predisposition to non‐medullary thyroid cancer. ABSTRACT Familial non‐medullary thyroid cancer, defined as two or more affected first‐degree relatives, accounts for 3 ...
Duygu Abbasoglu +9 more
wiley +1 more source
Improvement of 3D Visualization Capability of BIM Software [PDF]
, 2023 Önder Halis Bettemir, Faruk Ergen
openalex +1 more source
Cell Proliferation, EarlyView.Non‐coding RNAs (ncRNAs) regulate breast cancer radioresistance via cell cycle, DNA repair and tumour microenvironment pathways. Targeting ncRNAs (e.g., HOTAIR and miR‐155) with RNA‐based therapies (ASOs and CRISPR) shows promise but faces delivery challenges.
Xiaohui Zhao +8 more
wiley +1 more source
Association of metabolic obesity phenotypes with cognitive decline in the ELSA‐Brasil study
Diabetes, Obesity and Metabolism, EarlyView.Abstract Aims To investigate the association between metabolic obesity phenotypes and cognitive decline and evaluate the potential mediating role of C‐reactive protein (CRP). Methods Longitudinal cohort study using three waves (2008–2019) of the Brazilian Longitudinal Study of Adult Health (ELSA‐Brasil).
Paulo Henrique Lazzaris Coelho +9 more
wiley +1 more source
European Management Review, EarlyView.ABSTRACT Multi‐sided platform (MSP) models have become more relevant for incumbent companies, requiring them to develop MSP engagement strategies. This study sheds light on the complex process incumbents undergo in developing platform strategies. Adopting an inductive research design, we conducted interviews with 37 decision‐makers across 35 incumbent ...
Lukas Zechel, Vivek K. Velamuri
wiley +1 more source
Building product suggestions for a BIM model based on rule sets and a semantic reasoning engine [PDF]
, 2015 The architecture, engineering and construction (AEC) industry today relies on different information systems and computational tools built to support and assist in the building design and construction.
Costa, Gonçal, Pauwels, Pieter
core +1 more source
Limited roles of the miR‐17‐92 cluster in the regulation of T‐cell apoptosis
The FEBS Journal, EarlyView.The pro‐apoptotic protein BIM shapes T‐cell survival and function, but how it is regulated remains unclear. In a mouse model lacking direct miR‐17‐92:Bim interactions, we observed a moderate reduction in Th17 CD4+ T cells. BIM levels were modestly increased in double‐positive thymocytes and naive CD8+ T cells, but this did not affect overall T‐cell ...
Katharina Hoppe +7 more
wiley +1 more source
The BH3-only protein NOXA is essential for apoptosis induction by BH3-mimetics targeting BCL2 or BCL-X<sub>L</sub> in DLBCL. [PDF]
Br J HaematolSummary BCL2 inhibitors (BCL2i) have transformed the management of chronic lymphocytic leukaemia (CLL), but their use in more aggressive B‐cell malignancies such as diffuse large B‐Cell lymphoma (DLBCL) is complicated by the more heterogeneous nature of the disease.
Yildirim N +7 more
europepmc +2 more sources
The FEBS Journal, EarlyView.Proteostasis ensures proper protein folding, modification, and degradation, while its impairment triggers ER stress. Chronic ER stress and maladaptive UPR via the CHOP–ERO1 axis remodel ERMCs, altering calcium signaling and mitochondrial metabolism.
Giorgia Maria Renna +5 more
wiley +1 more source