Results 101 to 110 of about 6,896 (262)
Mechanical Activation of Piezo1 Drives Osteoarthritis Through Kdm5c‐Mediated Epigenetic Silencing
Advanced Science, EarlyView.Excessive mechanical stress activates Piezo1, triggering Ca2+‐dependent cytoskeletal forces that deform the nucleus and reduce H3K4me3. Kdm5c demethylates H3K4me3 at Col2a1 and Runx3 promoters. Kdm5c knockout rescues degradation. Repurposed telmisartan directly inhibits Kdm5c, blocking this axis and showing disease‐modifying efficacy in mouse OA models
Tianyou Kan +13 more
wiley +1 more source
Advanced Science, EarlyView.Human neutrophils exist as two epigenetically imprinted subtypes defined by stable CD177 expression or absence — a ratio that persists across time, circadian rhythms, and inflammation. CD177− neutrophils display a distinct molecular landscape enriched in arginase 1 and lipid metabolism markers, accumulate in head‐and‐neck tumors, and associate with ...
Marcel Jung +39 more
wiley +1 more source
Advanced Science, EarlyView.Eligibility flow and real‐world AMD burden in the UKB retinal imaging cohort and TMUEH external‐validation cohort. Overview of the ORBIT‐AMD architecture, integrating retinal representation pretraining, bilateral eye‐graph modeling and concept bottleneck learning to support ordered risk, bilateral context, interpretable lesion concepts, longitudinal ...
Xuehao Cui +3 more
wiley +1 more source
Advanced Electronic Materials, EarlyView.ABSTRACT With the continuous development of computer image processing, developing efficient and low‐power computing devices has become a key challenge. Memristors have integrated in‐situ storage and computing capabilities, making them an ideal choice for low‐power image processing computing architectures. However, current memristors are confronted with
Tengyu Li +4 more
wiley +1 more source
Advancing Energy Materials by In Situ Atomic Scale Methods
Advanced Energy Materials, Volume 15, Issue 11, March 18, 2025.Progress in in situ atomic scale methods leads to an improved understanding of new and advanced energy materials, where a local understanding of complex, inhomogeneous systems or interfaces down to the atomic scale and quantum level is required. Topics from photovoltaics, dissipation losses, phase transitions, and chemical energy conversion are ...
Christian Jooss +21 more
wiley +1 more source
Rising from the Ashes. II. The Bar-driven Abundance Bimodality of the Milky Way
The Astrophysical JournalThe Milky Way hosts at least two modes in its present-day distribution of Fe and α -elements. The exact cause of this bimodality is disputed, but one class of explanations involves the merger between the Milky Way and a relatively massive satellite (Gaia-
Angus Beane +5 more
doaj +1 more source
A Weighted Skew-Logistic Distribution with Applications to Environmental Data
MathematicsSkewness and bimodality properties are frequently observed when analyzing environmental data such as wind speeds, precipitation levels, and ambient temperatures.
Isaac Cortés +2 more
doaj +1 more source
Intrinsic Mechanical Parameters and their Characterization in Solid‐State Lithium Batteries
Advanced Energy Materials, Volume 15, Issue 11, March 18, 2025.This review focuses on the intrinsic mechanical parameters and their associated characterization in solid‐state batteries. The physical significance of mechanics parameters is introduced with exhaustive classifications by elastic, plastic deformations and fracture in bulk, adhesion, friction at interfaces, and mechanical fatigue in cells ...
Shuai Hao +5 more
wiley +1 more source
Advanced Energy Materials, EarlyView.The molecular design strategy that integrates both side chain and backbone engineering in diketopyrrolopyrrole‐based conjugated polymers to identify the optimal balance between doping efficiency and microstructural order is demonstrated. Comprehensive spectroscopic, electrochemical, morphological, and structural characterizations reveal that the ...
Taewoong Han +13 more
wiley +1 more source
Earth and Space ScienceGiven the essential implications of Kuroshio Extension (KE) bimodality on oceanic dynamical environment and climate, the present study investigates the targeted observation schemes, based on the conditional nonlinear optimal perturbation (CNOP) method ...
Yu Geng +5 more
doaj +1 more source