Results 71 to 80 of about 145 (144)

Sedentary ageing remodels the structure–function relationships that underlie calcium signalling at super‐resolution scales in the heart

open access: yesThe Journal of Physiology, EarlyView.
Abstract figure legend Illustration of calcium spark function and ryanodine receptor (RyR) structure within a sedentary model of ageing. Upon sympathetic stimulation from 1 µM isoprenaline a linear response to calcium spark morphology occurred, accompanied by a biphasic progression of RyR remodelling across age.
Miriam E. Hurley   +3 more
wiley   +1 more source

A Super‐Resolution Approach for Astrocyte‐Specific Molecular Imaging Reveals the Nanoscale Distribution of Monoacylglycerol Lipase, the Metabolic Node Between Endocannabinoid and Prostaglandin Signaling

open access: yesGlia, Volume 74, Issue 9, September 2026.
Dual‐color STORM resolves the precise architecture and protein distributions within hippocampal astrocytes at the nanoscale. Identification of a sparse but specific MAGL pool in CA1 astrocytic processes. Astrocytic MAGL is not synapse‐associated, suggesting a synapse‐independent role.
Miklós Zöldi, István Katona
wiley   +1 more source

A cofactor‐promiscuous HMGR from the Lyme disease pathogen illuminates diversity in bacterial isoprenoid biosynthesis

open access: yesProtein Science, Volume 35, Issue 9, September 2026.
Abstract The Lyme disease pathogen Borrelia burgdorferi contains a highly reduced genome lacking many primary metabolic pathways. However, B. burgdorferi retains the mevalonate pathway that synthesizes isopentenyl pyrophosphate (IPP), the precursor to the peptidoglycan carrier lipid.
Isaac A. Paddy   +7 more
wiley   +1 more source

Dietary restriction induces persistent multigenerational phenotypic effects in Phytoseiulus persimilis

open access: yesPest Management Science, Volume 82, Issue 9, Page 8725-8733, September 2026.
The study shows ancestral dietary restriction in Phytoseiulus persimilis produces persistent, sex‐specific, multi‐generational effects on survival and body size, with stronger maternal than paternal lineage influences despite nutritional recovery. Abstract BACKGROUND Transgenerational phenotypic plasticity (TGP) allows environmental effects to persist ...
Xia Chen   +4 more
wiley   +1 more source

Collaboration post‐acquisition: The role of acquirers' motives

open access: yesStrategic Management Journal, Volume 47, Issue 9, Page 2551-2589, September 2026.
Abstract Research Summary What role do collaborations with a target's partners play in an acquisition, and how do these collaborations evolve post‐acquisition? Research suggests that these collaborations are an important reason to acquire but often diminish post‐acquisition. But if they tend to diminish, why are they a reason to acquire?
Henning Piezunka   +3 more
wiley   +1 more source

Image Databases for Pollen Grain Classification: Availability, Quality, and Challenges

open access: yesWIREs Data Mining and Knowledge Discovery, Volume 16, Issue 3, September 2026.
Overview of the study process, from identifying gaps in pollen image databases to a systematic search across six libraries, resulting in 73 final studies, 18 datasets (10 public), and a seven‐point standardization framework proposed under FAIR principles.
Heloise Acco Tives Bedin   +4 more
wiley   +1 more source

The Mutable Original: How Chinese Counterfeits Become Nigerian Originals in African Markets

open access: yesAmerican Anthropologist, Volume 128, Issue 3, Page 581-594, September 2026.
ABSTRACT Affordable Chinese copies of Western brands are ubiquitous in African markets. Despite democratizing consumer access, these goods appear to cement hegemonic value hierarchies that rank Chinese or local products as inferior to Western goods.
Jing Jing Liu
wiley   +1 more source

Clinical Trial: Effectiveness and Safety of a Novel Anal Insert Device for Treatment of Faecal Incontinence

open access: yesAlimentary Pharmacology &Therapeutics, Volume 64, Issue 5, Page 603-614, September 2026.
StaySure is a novel anal insert device that safely and effectively treats medically refractory faecal incontinence. Treatment reduced incontinence episodes by 69%, improved quality of life beyond clinically meaningful thresholds, and was well tolerated with no treatment‐related serious adverse events. ABSTRACT Background Treatment options for medically‐
Adil E. Bharucha   +6 more
wiley   +1 more source

Punchline with(out) purpose: Integrating research on instructional humour and seductive details

open access: yesBritish Journal of Educational Psychology, Volume 96, Issue 3, Page 1272-1296, September 2026.
Abstract Introduction We integrated research on instructional humour and seductive details to investigate when affiliative course‐related humour is effective or rather ineffective for learning. We assumed that instructional humour without a cognitive function (irrelevant humour) would have detrimental effects on learning performance resembling the ...
Lisa Bender   +2 more
wiley   +1 more source

The selective degradation of PDE4B shortform, using a PROTAC, leads to inhibition of several hallmarks of cancer in HCT116 cells

open access: yesBritish Journal of Pharmacology, Volume 183, Issue 18, Page 5516-5540, September 2026.
Background and Purpose Colorectal cancer is one of the most prevalent cancers worldwide, and novel precision medicine approaches are rapidly improving patient outcomes. Phosphodiesterase 4B (PDE4B) is a member of an enzyme family (PDE4) that hydrolyses intracellular cAMP to control spatial and temporal signalling cues.
Alina Zorn   +11 more
wiley   +1 more source

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