Results 51 to 60 of about 58,723 (257)

CEACAM1 participation in breast cancer progression

open access: yesMolecular Oncology, EarlyView.
In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin   +3 more
wiley   +1 more source

Twin Binaries: Studies of Stability, Mass Transfer, and Coalescence

open access: yes, 2011
Motivated by suggestions that binaries with almost equal-mass components (“twins”) play an important role in the formation of double neutron stars and may be rather abundant among binaries, we study the stability of synchronized close and contact ...
Lombardi, James C., Jr. (Jamie)   +5 more
core   +1 more source

Mass Transfer in Two Post-AGB Binaries with Dusty Disks

open access: yesOpen Astronomy, 2012
We present a time series of high-resolution spectra for two poorly studied candidate post-AGB stars surrounded by dusty disks, BD+46 442 and IRAS 19135+3937. We find that both stars show radial velocity variations with periods of 130-140 days. IRAS 19135+
Gorlova N., Van Winckel H., Jorissen A.
doaj   +1 more source

Unique circulating miRNAome signatures captured with distinct molecular states in Lynch syndrome and sporadic colorectal cancer

open access: yesMolecular Oncology, EarlyView.
Circulating microRNA profiles distinguish nonmalignant Lynch syndrome from cancer‐associated Lynch syndrome, sporadic colorectal cancer, and healthy controls. Age‐stratified analysis reveals disease‐specific regulatory states, and a six‐miRNA panel shows concordant separation in an independent colorectal tissue cohort.
Ramadhani Salum Chambuso   +5 more
wiley   +1 more source

Features of globular cluster’s dynamics with an intermediate-mass black hole

open access: yesOpen Astronomy, 2018
In this paper, we address the question of how a central intermediate-mass black hole (IMBH) in a globular cluster (GC) affects dynamics, core collapse, and formation of the binary population.
Ryabova Marina V.   +3 more
doaj   +1 more source

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

open access: yesFEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz   +6 more
wiley   +1 more source

RoundMi: A quantitative method to analyze mitochondrial morphology in mitotic cells

open access: yesFEBS Open Bio, EarlyView.
RoundMi is a workflow for rapid analysis of mitochondrial morphology in mitotic cells. By combining adaptive preprocessing with automated segmentation and quantification, it enables accurate measurements from single focal plane images, reducing acquisition time and computational demands while remaining compatible with high‐throughput fixed and live ...
Elmira Parvindokht Bararpour   +2 more
wiley   +1 more source

An Extremely Massive White Dwarf of the Symbiotic Classical Nova V407 Cyg as Suggested by the RS Oph and U SCO Models

open access: yesOpen Astronomy, 2012
We have analyzed the optical light curve of the symbiotic star V407 Cyg that underwent a classical nova outburst in 2010 March. Being guided by a supersoft X-ray phase observed during days 20-40 after the nova outburst, we are able to reproduce the light
Hachisu I., Kato M.
doaj   +1 more source

Directed evolution of enzymes at the crossroads of tradition and innovation

open access: yesFEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova   +2 more
wiley   +1 more source

High inclination X-ray and cataclysmic binaries [PDF]

open access: yes, 1987
An introduction is given to the fields of X-ray and cataclysmic binaries, low mass X-ray binaries (LMXBs) and globular clusters. New observations of the W Vir star AC5 (=V86) are used show that it is probably the source of Hα emission previous authors ...
Naylor, T., Naylor, Timothy, Naylor, T
core   +1 more source

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