Results 51 to 60 of about 637,766 (337)

Counting maximal cycles in binary matroids

Discrete Mathematics, 1996
zbMATH Open Web Interface contents unavailable due to conflicting licenses.
openaire   +2 more sources

A large‐scale retrospective study in metastatic breast cancer patients using circulating tumour DNA and machine learning to predict treatment outcome and progression‐free survival

Molecular Oncology, EarlyView.
There is an unmet need in metastatic breast cancer patients to monitor therapy response in real time. In this study, we show how a noninvasive and affordable strategy based on sequencing of plasma samples with longitudinal tracking of tumour fraction paired with a statistical model provides valuable information on treatment response in advance of the ...
Emma J. Beddowes, Mario Ortega Duran, Solon Karapanagiotis, Alistair Martin, Meiling Gao, Riccardo Masina, Ramona Woitek, James Tanner, Fleur Tippin, Justine Kane, Jonathan Lay, Anja Brouwer, Stephen‐John Sammut, Suet‐Feung Chin, Davina Gale, Dana W. Y. Tsui, Sarah‐Jane Dawson, Nitzan Rosenfeld, Maurizio Callari, Oscar M. Rueda, Carlos Caldas   +20 more
wiley   +1 more source

The Quasi-Roche lobe overflow state in the evolution of Close Binary Systems containing a radio pulsar [PDF]

, 2014
We study the evolution of close binary systems formed by a normal (solar composition), intermediate mass donor star together with a neutron star. We consider models including irradiation feedback and evaporation.
Benvenuto, O. G., De Vito, M. A., Horvath, J. E.   +2 more
core   +3 more sources

Detecting homologous recombination deficiency for breast cancer through integrative analysis of genomic data

Molecular Oncology, EarlyView.
This study develops a semi‐supervised classifier integrating multi‐genomic data (1404 training/5893 validation samples) to improve homologous recombination deficiency (HRD) detection in breast cancer. Our method demonstrates prognostic value and predicts chemotherapy/PARP inhibitor sensitivity in HRD+ tumours.
Rong Zhu, Katherine Eason, Suet‐Feung Chin, Paul A. W. Edwards, Raquel Manzano Garcia, Richard Moulange, Jia Wern Pan, Soo Hwang Teo, Sach Mukherjee, Maurizio Callari, Carlos Caldas, Stephen‐John Sammut, Oscar M. Rueda   +12 more
wiley   +1 more source

Design and Thermodynamic Analysis of Waste Heat-Driven Liquid Metal–Water Binary Vapor Power Plant Onboard Ship

Journal of Marine Science and Engineering
Day after day, stricter environmental regulations and rising operating costs and fuel prices are forcing the shipping industry to find more effective ways of designing and operating energy-efficient ships.
Haydar Kepekci, Cuneyt Ezgi
doaj   +1 more source

Construction of Near-Capacity Protograph LDPC Code Sequences with Block-Error Thresholds

, 2015
Density evolution for protograph Low-Density Parity-Check (LDPC) codes is considered, and it is shown that the message-error rate falls double-exponentially with iterations whenever the degree-2 subgraph of the protograph is cycle-free and noise level is
Pradhan, Asit Kumar, Subramanian, Arunkumar, Thangaraj, Andrew   +2 more
core   +1 more source

Long secondary periods in variable red giants [PDF]

, 2009
‘The definitive version is available at www3.interscience.wiley.com '. Copyright Royal Astronomical Society. DOI: 10.1111/j.1365-2966.2009.15401.xWe present a study of a sample of Large Magellanic Cloud red giants exhibiting Long Secondary Periods (LSPs).
Cioni, M-R.L., Nicholls, C.P., Soszynski, I., Wood, P.R.   +3 more
core   +2 more sources

Milankovitch cycles of terrestrial planets in binary star systems [PDF]

Monthly Notices of the Royal Astronomical Society, 2016
The habitability of planets in binary star systems depends not only on the radiation environment created by the two stars, but also on the perturbations to planetary orbits and rotation produced by the gravitational field of the binary and neighbouring planets.
openaire   +5 more sources

Data‐driven discovery of gene expression markers distinguishing pediatric acute lymphoblastic leukemia subtypes

Molecular Oncology, EarlyView.
This study investigates gene expression differences between two major pediatric acute lymphoblastic leukemia (ALL) subtypes, B‐cell precursor ALL, and T‐cell ALL, using a data‐driven approach consisting of biostatistics and machine learning methods. Following analysis of a discovery dataset, we find a set of 14 expression markers differentiating the ...
Mona Nourbakhsh, Nikola Tom, Anna Schrøder Lassen, Helene Brasch Lind Petersen, Ulrik Kristoffer Stoltze, Karin Wadt, Kjeld Schmiegelow, Matteo Tiberti, Elena Papaleo   +8 more
wiley   +1 more source

Genomics‐led approach to drug testing in models of undifferentiated pleomorphic sarcoma

Molecular Oncology, EarlyView.
GA text Genomic data from undifferentiated pleomorphic sarcoma patients and preclinical models were used to inform a targeted drug screen. Selected compounds were tested in 2D and 3D cultures of UPS cell lines. A combination of trametinib and infigratinib was synergistic in the majority of UPS cell lines tested, which was further confirmed in an ex ...
Piotr J. Manasterski, Molly R. Danks, John P. Thomson, Morwenna Muir, Martin Lee, John C. Dawson, Ana T. Amaral, Juan Diaz‐Martin, David S. Moura, Javier Martin‐Broto, Ali Alsaadi, Donald M. Salter, Ailsa J. Oswald, Graeme Grimes, Larry Hayward, Ted R. Hupp, Karen Sisley, Paul H. Huang, Neil O. Carragher, Valerie G. Brunton   +19 more
wiley   +1 more source