Results 121 to 130 of about 796,772 (273)
Advanced Science, EarlyView.Tumor‐associated TP53 inactivation correlates with lipid droplet (LD) accumulation. High‐fat diets drive Cyb5r3‐Myh9‐mediated p53 enrichment on LD surfaces, accelerating its degradation while upregulating LD‐promoting factor CD36 expression to establish a feed‐forward loop. LD suppression or dietary intervention restores p53 and inhibits tumorigenesis,
Haiyang Liu +20 more
wiley +1 more source
CeiTEA: Adaptive Hierarchy of Single Cells with Topological Entropy
Advanced Science, EarlyView.CeiTEA, a novel hierarchical clustering algorithm based on topological entropy, effectively captures complex structures underlying data. By constructing an adaptive multi‐nary partition tree, CeiTEA reveals hierarchical structures and local diversifications, outperforming existing methods in clustering accuracy and consistency and providing the ...
Bowen Tan +3 more
wiley +1 more source
Advanced Science, EarlyView.A novel composite mapping strategy for peptide‐based data storage is presented, which enhances coding density by using composite letters made up of multiple amino acids. This approach significantly increases data encoding capacity, achieving 15 bits per letter.
Anxun Zhang +8 more
wiley +1 more source
A Novel nor@DHB Matrix for Direct Microbial Analysis in Lung Cancer Tissues
Advanced Science, EarlyView.Integrated matrix‐assisted laser desorption/ionization mass spectrometry workflow quantifies intratumoral microbes in lung cancer through lipopolysaccharide/lipid A extraction from biopsies. The novel ionic matrix called norharmane conjugated to 2,5‐dihydroxybenzoic acid enhances lipid A ionization, enabling direct detection of bacterial genera ...
Liang Shan +12 more
wiley +1 more source
Advanced Science, EarlyView.This work introduces E‐GeoGNN, a graph neural network framework that systematically encodes molecular structural information through three hierarchical correlation graphs: atom‐bond graph, bond‐angle graph, and angle‐dihedral graph. By incorporating quantum and geometric dual‐scale self‐supervised pretraining, Q‐GEM is proposed, a novel molecular ...
Zhijiang Yang +7 more
wiley +1 more source
Transparent and Transient Flexible Electronics
Advanced Science, EarlyView.Transparent electronics has gained tremendous attention in recent years because of the growing demand for see‐through devices in applications such as displays, windscreens, and wearables. This review discusses the recent developments related to transparent electronics as well as the challenges associated with the development of flexible and transient ...
Nitheesh M. Nair +2 more
wiley +1 more source
Dynamics between the obstacles of business environment and firm performance in Bangladesh: Survey-based empirical insights using ML algorithms. [PDF]
HeliyonRoy CK.
europepmc +1 more source
A Wearable In‐Pad Diagnostic for the Detection of Disease Biomarkers in Menstruation Blood
Advanced Science, EarlyView.MenstruAI integrates a paper‐based biosensor into sanitary pads to detect biomarkers in menstrual blood, enabling accessible, lab‐free diagnostics health. The platform supports early disease detection, especially in underserved communities, while challenging menstrual stigma and opening pathways for scalable, inclusive, and sustainable population ...
Lucas Dosnon +3 more
wiley +1 more source
Surface Activity of Hydrophobized Modified Starch Hydrolysates in Mixed Systems. [PDF]
Materials (Basel)Konował E, Sybis M, Prochaska K.
europepmc +1 more source
The Neglected Role of GSDMD C‐Terminal in Counteracting Type I Interferon Signaling
Advanced Science, EarlyView.The C‐terminal domain of Gasdermin D (GSDMD‐CT) shows functions beyond pyroptosis. GSDMD‐CT negatively regulates IFN‐I signaling during viral infection by triggering autophagic degradation of RIG‐I and TBK1. GSDMD‐CT interacts with retinoic acid‐inducible gene‐I (RIG‐I) and tank‐binding kinase 1 (TBK1), leading to TRIM28‐mediated ubiquitination and ...
Weilv Xu +17 more
wiley +1 more source