Results 61 to 70 of about 515,369 (301)

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

Bubble formation in active binary mixture model

Physical Review Research
Phase separation, the spontaneous segregation of density, is a ubiquitous phenomenon observed across diverse physical and biological systems. Within a crowd of motile elements, active phase separation emerges from the interplay of activity (i.e., self ...
Kyosuke Adachi
doaj   +1 more source

Domain wall suppression in trapped mixtures of Bose-Einstein condensates

, 2012
The ground state energy of a binary mixture of Bose-Einstein condensates can be estimated for large atomic samples by making use of suitably regularized Thomas-Fermi density profiles.
A. L. Fetter, Francesco V. Pepe, Giuseppe Florio, L. Pitaevskij, M. Abramowitz, Paolo Facchi, Saverio Pascazio   +6 more
core   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

Coexisting Pulses in a Model for Binary-Mixture Convection

, 1995
We address the striking coexistence of localized waves (`pulses') of different lengths which was observed in recent experiments and full numerical simulations of binary-mixture convection.
B. Malomed, D. Bensimon, E. Moses, H. Brand, H. Herrero, H. Riecke, H. Riecke, H. Riecke, H. Riecke, Hermann Riecke, J. Niemela, L. Pismen, M. Cross, M. Renardy, O. Thual, P. Kolodner, P. Kolodner, P. Kolodner, R. Deissler, R. Heinrichs, V. Hakim, W. Barten, Wouter-Jan Rappel   +22 more
core   +2 more sources

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

FEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz, Bart Geverts, Johan A. Slotman, Andrea Sacchetti, Stefan Prekovic, Martin E. van Royen, Adriaan B. Houtsmuller   +6 more
wiley   +1 more source

An investigation on removal of ciprofloxacin and norfloxacin by phycoremediation with an emphasis on acute toxicity and biochemical composition

Scientific Reports, 2023
Ciprofloxacin (CIP) and norfloxacin (NOR) belong to the class of emerging contaminants that are frequently detected in the aquatic environment as a binary mixture, responsible for the development of antibiotic-resistant genes and antibiotic-resistant ...
R. Ricky, S. Shanthakumar
doaj   +1 more source

Sound-propagation gap in fluid mixtures [PDF]

, 2006
We discuss the behavior of the extended sound modes of a dense binary hard-sphere mixture. In a dense simple hard-sphere fluid the Enskog theory predicts a gap in the sound propagation at large wave vectors.
A. A. van Well, A. Campa, E. G. D. Cohen, I. M. de Schepper, I. M. de Schepper, I. M. de Schepper, I. M. de Schepper, J. B. Suck, J. Bosse, J. M. Kincaid, J. P. Boon, J. R. D. Copley, M. Cristina Marchetti, P. B. Lerner, Supurna Sinha, T. R. Kirkpatrick   +15 more
core   +3 more sources

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

FEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill, Yelyzaveta Pulnova, Elke De Zitter, Helen M. Ginn, Briony A. Yorke   +4 more
wiley   +1 more source

Cutaneous Melanoma Drives Metabolic Changes in the Aged Bone Marrow Immune Microenvironment

Aging and Cancer, EarlyView.
Melanoma, the deadliest form of skin cancer, increasingly affects older adults. Our study reveals that melanoma induces changes in iron and lipid levels in the bone marrow, impacting immune cell populations and increasing susceptibility to ferroptosis.
Alexis E. Carey, Murilo Ramos Rocha, Cheyenne Palm, Vania Wang, Denys Balandin, Ethan Black, Kevin Y. Zhang, Fan Huang, Daniel J. Zabransky, Yash Chhabra, Mareike Peters, Gabriel Ghiaur, Ashani Weeraratna   +12 more
wiley   +1 more source