Results 51 to 60 of about 1,010,486 (283)

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

Relation Extraction in Biomedical Texts Based on Multi-Head Attention Model With Syntactic Dependency Feature: Modeling Study

JMIR Medical Informatics, 2022
BackgroundWith the rapid expansion of biomedical literature, biomedical information extraction has attracted increasing attention from researchers.
Yongbin Li, Linhu Hui, Liping Zou, Huyang Li, Luo Xu, Xiaohua Wang, Stephanie Chua   +6 more
doaj   +1 more source

Identification of amino acids essential for angulin‐1/3 binding of the tricellular tight junction binder, angubindin‐1

FEBS Open Bio, EarlyView.
Angubindin‐1 binds angulin‐1/‐3 at tricellular tight junctions, enhancing intestinal macromolecule permeation. Alanine scanning identified six essential residues (L562, L598, E638, V640, Y643, and K644) of angubindin‐1 critical for binding to angulin‐1/‐3 and permeation‐enhancing activity, providing insights for the development of targeted noninvasive ...
Taiki Kuzu, Yumi Iwashita, Keisuke Tachibana, Itsuki Nishino, Yuki Niwa, Atsuko Uyeda, Kazuki Matsuo, Masahiro Nagahama, Masuo Kondoh   +8 more
wiley   +1 more source

Ample Spectrum Contractions and Related Fixed Point Theorems

Mathematics, 2019
Simulation functions were introduced by Khojasteh et al. as a method to extend several classes of fixed point theorems by a simple condition. After that, many researchers have amplified the knowledge of such kind of contractions in several ways.
Antonio Francisco Roldán López de Hierro, Naseer Shahzad   +1 more
doaj   +1 more source

The Stokes-Einstein Relation in Supercooled Aqueous Solutions of Glycerol

, 2006
The diffusion of glycerol molecules decreases with decreasing temperature as its viscosity increases in a manner simply described by the Stokes-Einstein(SE) relation. Approaching the glass transition, this relation breaks down as it does with a number of
A. Einstein, Bo Chen, C. Gao, D. J. Tomlinson, E. E. Sigmund, E. Jenckel, G. Tamman, G. S. Fulcher, H. Vogel, W. P. Halperin   +9 more
core   +1 more source

Serum Neurofilament Light Chain in Multiple Sclerosis: Superiority of Age‐ and BMI‐Corrected Z Scores/Percentiles Over Absolute Cutoff Values for Prediction of Treatment Response

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Prognostication of disease course and prediction of treatment response in multiple sclerosis is an unmet need. We compared the performance of serum neurofilament light chain Z scores (age‐ and BMI‐adjusted) with absolute concentrations for the prediction of response to disease‐modifying therapy.
Maximilian Einsiedler, Aleksandra Maleska Maceski, Sofia Sandgren, Johanna Oechtering, Sabine Schaedelin, Lisa Hofer, Amar Zadic, Juan Francisco Vilchez Gomez, Lester Melie‐Garcia, Alessandro Cagol, Riccardo Galbusera, Sebastian Finkener, Patrice Lalive, Marjolaine Uginet, Stefanie Müller, Caroline Pot, Amandine Mathias, Renaud Du Pasquier, Robert Hoepner, Andrew Chan, Giulio Disanto, Chiara Zecca, Marcus D’Souza, Lars G. Hemkens, Tobias Derfuss, Özgür Yaldizli, Patrick Roth, Claudio Gobbi, David Brassat, Björn Tackenberg, Henrik Zetterberg, Tjalf Ziemssen, Heinz Wiendl, Klaus Berger, Marco Hermesdorf, Fredrik Piehl, Ludwig Kappos, Cristina Granziera, Ahmed Abdelhak, David Leppert, Eline A. J. Willemse, Pascal Benkert, Jens Kuhle, Swiss Multiple Sclerosis Cohort Study (SMSC)   +43 more
wiley   +1 more source

A generalization of majorization that characterizes Shannon entropy

, 2016
We introduce a binary relation on the finite discrete probability distributions which generalizes notions of majorization that have been studied in quantum information theory.
Mueller, Markus P., Pastena, Michele
core   +1 more source

The rs10191329 Risk Allele Is Associated With Pronounced Retinal Layer Atrophy in Multiple Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To investigate whether the rs10191329 risk allele in the DYSF–ZNF638 locus, which is implicated in central nervous system resilience rather than immune‐mediated pathology, is associated with retinal layer thinning, a biomarker of neuroaxonal damage in relapsing multiple sclerosis (RMS). Methods From a prospective observational study,
Gabriel Bsteh, Ruchi Tanavade, Nik Krajnc, Fabian Föttinger, Theresa König, Martin Krenn, Lukas Haider, Barbara Kornek, Fritz Leutmezer, Kerstin U. Ludwig, Stefan Macher, Tobias Monschein, Markus Ponleitner, Paulus Rommer, Christiane Schmied, Karin Zebenholzer, Tobias Zrzavy, Gudrun Zulehner, Franziska Di Pauli, Axel Schmidt, Harald Hegen, Berthold Pemp, Thomas Berger   +22 more
wiley   +1 more source

Relational Almost (ϕ,ψ)-Contractions and Applications to Nonlinear Fredholm Integral Equations

Axioms
This paper deals with the fixed-point findings under relational strict almost (ϕ,ψ)-contraction. Our findings complement and strengthen prevailing results.
Fahad M. Alamrani, Ebrahem A. Algehyne, Esmail Alshaban, Adel Alatawi, Hamid I. A. Mohammed, Faizan Ahmad Khan   +5 more
doaj   +1 more source

Common Fixed Point Theorems for Generalized Contractive Pair of Mappings in a Metric Space and Their Application to Fractional Calculus

Journal of Applied Mathematics, 2022
In this manuscript, we have established relation-theoretic version of some common fixed point results in metric space for generalized β−ϕ−Z-contractive pair of mappings furnished with an arbitrary binary relation R.
Priya Goel, Manoj Kumar, Dimple Singh, Kamal Kumar   +3 more
doaj   +1 more source