Results 61 to 70 of about 986,794 (335)

Detecting homologous recombination deficiency for breast cancer through integrative analysis of genomic data

Molecular Oncology, EarlyView.
This study develops a semi‐supervised classifier integrating multi‐genomic data (1404 training/5893 validation samples) to improve homologous recombination deficiency (HRD) detection in breast cancer. Our method demonstrates prognostic value and predicts chemotherapy/PARP inhibitor sensitivity in HRD+ tumours.
Rong Zhu, Katherine Eason, Suet‐Feung Chin, Paul A. W. Edwards, Raquel Manzano Garcia, Richard Moulange, Jia Wern Pan, Soo Hwang Teo, Sach Mukherjee, Maurizio Callari, Carlos Caldas, Stephen‐John Sammut, Oscar M. Rueda   +12 more
wiley   +1 more source

Refinements to Relation-Theoretic Contraction Principle

Axioms, 2022
After the appearance of relation-theoretic contraction principle proved in a metric space equipped with an amorphous binary relation (often termed as relational metric space), various core fixed point results have been proved in the setting of different ...
Aftab Alam, Reny George, Mohammad Imdad
doaj   +1 more source

Operations on binary relations and their applications [PDF]

Bulletin of the American Mathematical Society, 1964
This paper is a rapid report from the author and the results are given without proofs. The author defines types of relations by means of semi-closure operations and discusses the existence of the smallest relation of a given type. By providing semi-closure operations with the condition ``join conservative'', a method of construction of the smallest ...
openaire   +4 more sources

Data‐driven discovery of gene expression markers distinguishing pediatric acute lymphoblastic leukemia subtypes

Molecular Oncology, EarlyView.
This study investigates gene expression differences between two major pediatric acute lymphoblastic leukemia (ALL) subtypes, B‐cell precursor ALL, and T‐cell ALL, using a data‐driven approach consisting of biostatistics and machine learning methods. Following analysis of a discovery dataset, we find a set of 14 expression markers differentiating the ...
Mona Nourbakhsh, Nikola Tom, Anna Schrøder Lassen, Helene Brasch Lind Petersen, Ulrik Kristoffer Stoltze, Karin Wadt, Kjeld Schmiegelow, Matteo Tiberti, Elena Papaleo   +8 more
wiley   +1 more source

Relation Extraction in Biomedical Texts Based on Multi-Head Attention Model With Syntactic Dependency Feature: Modeling Study

JMIR Medical Informatics, 2022
BackgroundWith the rapid expansion of biomedical literature, biomedical information extraction has attracted increasing attention from researchers.
Yongbin Li, Linhu Hui, Liping Zou, Huyang Li, Luo Xu, Xiaohua Wang, Stephanie Chua   +6 more
doaj   +1 more source

The Stokes-Einstein Relation in Supercooled Aqueous Solutions of Glycerol

, 2006
The diffusion of glycerol molecules decreases with decreasing temperature as its viscosity increases in a manner simply described by the Stokes-Einstein(SE) relation. Approaching the glass transition, this relation breaks down as it does with a number of
A. Einstein, Bo Chen, C. Gao, D. J. Tomlinson, E. E. Sigmund, E. Jenckel, G. Tamman, G. S. Fulcher, H. Vogel, W. P. Halperin   +9 more
core   +1 more source

Molecular imaging predicts trastuzumab‐deruxtecan (T‐DXd) response in head and neck cancer xenograft models

Molecular Oncology, EarlyView.
Trastuzumab‐deruxtecan, a HER2‐targeting antibody‐drug conjugate, shows promising antitumor activity in head and neck squamous cell carcinoma with low HER2 expression. In vitro and in vivo studies demonstrated dose‐dependent cell death and tumor growth reduction in low HER2‐expressing cell lines, which correlated with drug accumulation measured using a
Abdullah Bin Naveed, Lucas Mani, Muhammad Bilal Mirza, Ashtyn McAdoo, Takahito Kondo, Hidenori Tanaka, Nicole Meeks, Eben Rosenthal, Marisa Hom   +8 more
wiley   +1 more source

Suzuki-type fixed point theorems in relational metric spaces with applications [PDF]

Mathematica Moravica
In this paper, we establish a relation-theoretic version of the results presented by Kim et al. (Journal of Nonlinear and Convex Analysis, 16 (9) (2015), 1779-1786).
Khantwal Deepak, Pant Rajendra
doaj   +1 more source

Genomics‐led approach to drug testing in models of undifferentiated pleomorphic sarcoma

Molecular Oncology, EarlyView.
GA text Genomic data from undifferentiated pleomorphic sarcoma patients and preclinical models were used to inform a targeted drug screen. Selected compounds were tested in 2D and 3D cultures of UPS cell lines. A combination of trametinib and infigratinib was synergistic in the majority of UPS cell lines tested, which was further confirmed in an ex ...
Piotr J. Manasterski, Molly R. Danks, John P. Thomson, Morwenna Muir, Martin Lee, John C. Dawson, Ana T. Amaral, Juan Diaz‐Martin, David S. Moura, Javier Martin‐Broto, Ali Alsaadi, Donald M. Salter, Ailsa J. Oswald, Graeme Grimes, Larry Hayward, Ted R. Hupp, Karen Sisley, Paul H. Huang, Neil O. Carragher, Valerie G. Brunton   +19 more
wiley   +1 more source

Topological Connectedness and Behavioral Assumptions on Preferences: A Two-Way Relationship

, 2018
This paper offers a comprehensive treatment of the question as to whether a binary relation can be consistent (transitive) without being decisive (complete), or decisive without being consistent, or simultaneously inconsistent or indecisive, in the ...
Khan, M. Ali, Uyanık, Metin
core   +1 more source