Results 61 to 70 of about 1,421,542 (340)

A large‐scale retrospective study in metastatic breast cancer patients using circulating tumour DNA and machine learning to predict treatment outcome and progression‐free survival

Molecular Oncology, EarlyView.
There is an unmet need in metastatic breast cancer patients to monitor therapy response in real time. In this study, we show how a noninvasive and affordable strategy based on sequencing of plasma samples with longitudinal tracking of tumour fraction paired with a statistical model provides valuable information on treatment response in advance of the ...
Emma J. Beddowes, Mario Ortega Duran, Solon Karapanagiotis, Alistair Martin, Meiling Gao, Riccardo Masina, Ramona Woitek, James Tanner, Fleur Tippin, Justine Kane, Jonathan Lay, Anja Brouwer, Stephen‐John Sammut, Suet‐Feung Chin, Davina Gale, Dana W. Y. Tsui, Sarah‐Jane Dawson, Nitzan Rosenfeld, Maurizio Callari, Oscar M. Rueda, Carlos Caldas   +20 more
wiley   +1 more source

The Orbital Architecture of Qatar-6: A Fully Aligned Three-body System?

The Astronomical Journal, 2023
The evolutionary history of an extrasolar system is, in part, fossilized through its planets’ orbital orientations relative to the host star’s spin axis.
Malena Rice, Songhu Wang, Konstantin Gerbig, Xian-Yu Wang, Fei Dai, Dakotah Tyler, Howard Isaacson, Andrew W. Howard   +7 more
doaj   +1 more source

Compact radio emission indicates a structured jet was produced by a binary neutron star merger [PDF]

Science, 2018
Merging produced a structured jet The binary neutron star merger event GW170817 was observed with gravitational waves and across the electromagnetic spectrum.
G. Ghirlanda, O. Salafia, Z. Paragi, M. Giroletti, Junxiong Yang, J. Yang, B. Marcote, J. Blanchard, I. Agudo, T. An, M. Bernardini, R. Beswick, M. Branchesi, S. Campana, C. Casadio, É. Chassande-Mottin, M. Colpi, S. Covino, P. D’Avanzo, V. D’Elia, S. Frey, M. Gawroński, G. Ghisellini, L. Gurvits, P. Jonker, P. Jonker, H. V. Langevelde, A. Melandri, J. Moldón, L. Nava, A. Perego, M. Pérez-Torres, M. Pérez-Torres, C. Reynolds, R. Salvaterra, G. Tagliaferri, T. Venturi, S. Vergani, Ming Zhang   +38 more
semanticscholar   +1 more source

Detecting homologous recombination deficiency for breast cancer through integrative analysis of genomic data

Molecular Oncology, EarlyView.
This study develops a semi‐supervised classifier integrating multi‐genomic data (1404 training/5893 validation samples) to improve homologous recombination deficiency (HRD) detection in breast cancer. Our method demonstrates prognostic value and predicts chemotherapy/PARP inhibitor sensitivity in HRD+ tumours.
Rong Zhu, Katherine Eason, Suet‐Feung Chin, Paul A. W. Edwards, Raquel Manzano Garcia, Richard Moulange, Jia Wern Pan, Soo Hwang Teo, Sach Mukherjee, Maurizio Callari, Carlos Caldas, Stephen‐John Sammut, Oscar M. Rueda   +12 more
wiley   +1 more source

On the universal outcome of star-formation: Is there a link between stars and brown-dwarfs?

, 2003
(abridged) The recent evidence obtained by Briceno et al. that star-formation in Taurus-Auriga (TA) may be producing significantly fewer brown dwarfs (BDs) per star than the ONC is investigated by setting up a realistic model stellar plus BD population ...
Aarseth, Adams, Bate, Bhattacharyya, Bonnell, Bontemps, Boss, Boss, Bouvier, Bouvier, Bouy, Briceno, Burgasser, Burkert, Carpenter, Close, de la Fuente Marcos, Delgado-Donate, Duchêne, Duchêne, Duquennoy, Elmegreen, Estelle Moraux, Fischer, Gaspard Duchêne, Gizis, Gizis, Gomez, Haisch, Halbwachs, Hartigan, Hartmann, Hartmann, Hartmann, Henry, Hillenbrand, Hillenbrand, Horton, Jerome Bouvier, Kroupa, Kroupa, Kroupa, Kroupa, Kroupa, Kroupa, Kroupa, Kroupa, Kroupa, Kroupa, Kroupa, Köhler, Lada, Leinert, Luhman, Luhman, Marcy, Martín, Martín, Mathieu, Matzner, Mayor, Mazeh, Mermilliod, Moraux, Motte, Muench, Muench, Myers, Padoan, Pavel Kroupa, Pinfield, Prosser, Reid, Reipurth, Reipurth, Richichi, Sterzik, Sterzik, White, White, White, Woitas, Wuchterl   +82 more
core   +1 more source

The Electromagnetic Counterpart of the Binary Neutron Star Merger LIGO/Virgo GW170817. II. UV, Optical, and Near-infrared Light Curves and Comparison to Kilonova Models [PDF]

, 2017
We present UV, optical, and near-infrared (NIR) photometry of the first electromagnetic counterpart to a gravitational wave source from Advanced Laser Interferometer Gravitational-wave Observatory (LIGO)/Virgo, the binary neutron star merger GW170817 ...
P. Cowperthwaite, E. Berger, V. Villar, B. Metzger, M. Nicholl, R. Chornock, P. Blanchard, W. Fong, R. Margutti, M. Soares-Santos, K. Alexander, S. Allam, J. Annis, D. Brout, D. Brown, R. Butler, H.-Y. Chen, H. Diehl, Zoheyr Doctor, M. Drout, T. Eftekhari, B. Farr, D. Finley, R. Foley, J. Frieman, C. Fryer, J. Garc'ia-Bellido, M. Gill, J. Guillochon, K. Herner, D. Holz, D. Kasen, R. Kessler, J. Marriner, T. Matheson, E. Neilsen, Jr., E. Quataert, A. Palmese, A. Rest, M. Sako, D. Scolnic, N. Smith, D. Tucker, P. G. Williams, E. Balbinot, J. Carlin, E. Cook, F. Durret, T. Li, P. Lopes, A. C. C. Lourencco, J. Marshall, G. Medina, J. Muir, R. Muñoz, M. Sauseda, D. Schlegel, L. Secco, A. K. Vivas, W. Wester, A. Zenteno, Y. Zhang, T. Abbott, M. Banerji, K. Bechtol, A. Benoit-Lévy, E. Bertin, E. Buckley-Geer, D. Burke, D. Capozzi, A. Rosell, M. Kind, F. Castander, M. Crocce, C. Cunha, C. D'Andrea, L. Costa, C. Davis, D. DePoy, S. Desai, J. Dietrich, A. Drlica-Wagner, T. Eifler, A. Evrard, E. Fernández, B. Flaugher, P. Fosalba, E. Gaztañaga, D. Gerdes, T. Giannantonio, D. Goldstein, D. Gruen, R. Gruendl, G. Gutiérrez, K. Honscheid, B. Jain, D. James, T. Jeltema, M. Johnson, M. Johnson, S. Kent, E. Krause, R. Kron, K. Kuehn, N. Kuropatkin, O. Lahav, M. Lima, H. Lin, M. Maia, M. March, P. Martini, R. McMahon, F. Menanteau, C. Miller, R. Miquel, J. Mohr, E. Neilsen, R. Nichol, R. Ogando, A. Plazas, N. Roe, A. Romer, A. Roodman, E. Rykoff, E. Sánchez, V. Scarpine, R. Schindler, M. Schubnell, I. Sevilla-Noarbe, M. Smith, R. C. Smith, F. Sobreira, E. Suchyta, M. Swanson, G. Tarlé, D. Thomas, R. Thomas, M. Troxel, V. Vikram, A. Walker, Risa Wechsler, J. Weller, B. Yanny, J. Zuntz   +144 more
semanticscholar   +1 more source

Improving the NRTidal model for binary neutron star systems [PDF]

Physical Review D, 2019
Accurate and fast gravitational waveform (GW) models are essential to extract information about the properties of compact binary systems that generate GWs.
T. Dietrich, A. Samajdar, Sebastian Khan, N. Johnson-McDaniel, R. Dudi, W. Tichy   +5 more
semanticscholar   +1 more source

Data‐driven discovery of gene expression markers distinguishing pediatric acute lymphoblastic leukemia subtypes

Molecular Oncology, EarlyView.
This study investigates gene expression differences between two major pediatric acute lymphoblastic leukemia (ALL) subtypes, B‐cell precursor ALL, and T‐cell ALL, using a data‐driven approach consisting of biostatistics and machine learning methods. Following analysis of a discovery dataset, we find a set of 14 expression markers differentiating the ...
Mona Nourbakhsh, Nikola Tom, Anna Schrøder Lassen, Helene Brasch Lind Petersen, Ulrik Kristoffer Stoltze, Karin Wadt, Kjeld Schmiegelow, Matteo Tiberti, Elena Papaleo   +8 more
wiley   +1 more source

Polar Circumtriple Planets and Disks around Misaligned Hierarchical Triple Stars

The Astrophysical Journal
Observations of hierarchical triple-star systems show that misalignments are common both between the angular momentum vector of the inner binary and the outer companion orbit, and between the outer binary orbit and a circumtriple gas disk.
Stephen Lepp, Rebecca G. Martin, Stephen H. Lubow   +2 more
doaj   +1 more source

Massive double compact object mergers: gravitational wave sources and r-process-element production sites

, 2014
With our galactic evolutionary code that contains a detailed intermediate mass and massive binary population model, we study the temporal evolution of the galactic population of double neutron star binaries, mixed systems with a neutron star and black ...
Mennekens, N., Vanbeveren, D.
core   +1 more source