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Evolutionarily divergent DUF4465 domains have a common vitamin B12‐binding function

open access: yesFEBS Open Bio, EarlyView.
We show that DUF4465 family proteins, widespread across bacteria from gut microbiomes, hydrothermal vents, and soil, share a common vitamin B12‐binding function. These augmented β‐jellyroll proteins bind vitamin B12 via extended loops. Our findings establish sequence‐diverse DUF4465 proteins as a widespread class of B12‐binding proteins, highlighting ...
Charlea Clarke   +4 more
wiley   +1 more source

AI-Driven De Novo Binder Design: From Structure Prediction to Closed-Loop Optimization. [PDF]

open access: yesComput Struct Biotechnol J
Li X   +9 more
europepmc   +1 more source

Waste Glass Powder as a Circular-Economy Precursor in Geopolymer Binders. [PDF]

open access: yesMaterials (Basel)
Mohan Kumar SGK   +3 more
europepmc   +1 more source

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