Results 241 to 250 of about 3,573,689 (297)

Autophagosome marker, LC3, is released extracellularly via several distinct pathways

FEBS Open Bio, EarlyView.
This study establishes a novel HiBiT‐tagging system for ultrasensitive detection of LC3, revealing multiple pathways for its extracellular secretion. It demonstrates that LC3 is released via both autophagy‐dependent and ‐independent mechanisms, including a novel route for nonlipidated LC3‐I.
Koki Saito, Masashi Arakawa, Koki Maeda, Eiji Morita   +3 more
wiley   +1 more source

Computational repurposing of approved drugs targeting KRAS G12D and EGFR for colorectal cancer therapy. [PDF]

PLoS One
Ibraheem W, Alsheikh F, Alzain AA, Bhongade BA, Ejaz L, Baig H, Robinson RC, El-Tanani M.   +7 more
europepmc   +1 more source

An interview with Paul Binding

, 2015
Nick Turner, Paul Binding
openalex   +1 more source

Author response: Restoring data balance via generative models of T cell receptors for antigen-binding prediction

Emanuele Loffredo, Mauro Pastore, Simona Cocco, Rémi Monasson   +3 more
openalex   +1 more source

Analysis of Treacher Collins syndrome 4‐associated mutations in Schizosaccharomyces pombe

FEBS Open Bio, EarlyView.
Fission yeast models carrying Treacher Collins syndrome type 4‐associated mutations reveal that impaired processivity of RNA polymerase I leads to defective rRNA transcription. This study highlights the essential role of a conserved arginine residue in Pol I elongation and provides mechanistic insight into the pathogenesis of ribosomopathies.
Kei Kawakami, Hiroaki Kato
wiley   +1 more source

Molecular driving force of a small molecule-induced protein disorder-order transition. [PDF]

Commun Chem
Mendoza-Martinez C, Gupta AA, Llabrés S, Barlow PN, Michel J.   +4 more
europepmc   +1 more source

Novel Heteroleptic Complexes of O- and N-Donor Isophthalate–Nicotinamide Ligands: Binding Modes, Thermal Behavior and Multi-Characterization of Supramolecular Structures

Tuğrul Yıldırım, Mustafa Burak Telli, Dursun Ali Köse, Esma Sari, Zarife Sibel Şahin   +4 more
openalex   +1 more source

DDX3X induces mesenchymal transition of endothelial cells by disrupting BMPR2 signaling

FEBS Open Bio, EarlyView.
Elevated DDX3X expression led to downregulation of BMPR2, a key regulator of endothelial homeostasis and function. Our co‐immunoprecipitation assays further demonstrated a molecular interaction between DDX3X and BMPR2. Notably, DDX3X promoted lysosomal degradation of BMPR2, thereby impairing its downstream signaling and facilitating endothelial‐to ...
Yu Zhang, Jing Wang, De‐Hui Qian, Yang‐Fan Lv, Tian‐Le Cheng, Da‐Peng Wang, Jing Zhang, Ye Fan   +7 more
wiley   +1 more source

Mutation-Induced Resistance of SARS-CoV-2 M^pro to WU-04 Revealed by Multi-Scale Modeling. [PDF]

Int J Mol Sci
Liu M, Zhao D, Duan H, Zhu J, Zheng L, Yuan N, Xia Y, Sang P, Yang L.   +8 more
europepmc   +1 more source

Novel immunogenic T cell epitope of the HBV core protein with multiple overlapping binding registers in HLA-DR13

Schreiber, Sophia, Goeppert, Simone
openalex   +1 more source