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Metal-binding sites in proteins
Current Opinion in Biotechnology, 1991A dramatic increase in the number of solved metalloprotein structures and recent breakthroughs in structural analysis have provided a sufficiently detailed understanding of the structural chemistry of some metal-binding sites to allow successful design.
Elizabeth D. Getzoff +2 more
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Database Searches for Binding Sites
Science, 2000In their Report “Identification of a coordinate regulator of interleukins 4, 13, and 5 by cross-species sequence comparisons” (7 Apr., p. [136][1]), G. G. Loots and colleagues identify conserved noncoding sequences (CNSs) in orthologous regions of the interleukin (IL)-4/13/5 locus of ...
K, Murphy +3 more
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Peripheral benzodiazepine binding sites
Pharmacology & Therapeutics, 1989Article de synthese sur les sites de fixation peripheriques des benzodiazepines: distribution, fixation biologique, action au niveau du systeme nerveux central, regulation par le GABA et le stress, regulation endocrine, relation avec les canaux calcium, autres ligands, role ...
Markku Räty, Veijo Saano, Lembit Rägo
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Substrate-binding sites in acetylcholinesterase
Trends in Pharmacological Sciences, 1991Acetylcholinesterase is among the most efficient enzymes known. In order to provide an explanation for its catalytic and regulatory mechanisms, including the high turnover rate, the specific amino acid residues involved in substrate binding and hydrolysis need to be identified.
Christoph Weise +2 more
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A citrate-binding site in calmodulin
Journal of Molecular Recognition, 1998Calmodulin (CaM) is a major Ca2+ messenger which, upon Ca2+ activation, binds and activates a number of target enzymes involved in crucial cellular processes. The dependence on Ca2+ ion concentration suggests that CaM activation may be modulated by low-affinity Ca2+ chelators.
Karol A. Muszkat +3 more
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Binding sites for calcium on tubulin
Biochemistry, 1977Calcium ions can inhibit the in vitro assembly of microtubules and, therefore, may play a role in the regulation of microtubule formation in vivo. In order to test the validity of this hypothesis; the interaction between calcium and pruified brain microtubular protein has been investigated by standard binding assays.
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Hydrophobic binding site in acetylcholinesterase
Journal of Medicinal Chemistry, 1975The dissociation constants have been determined and compared for a series of reversible, noncovalent inhibitors of eel acetylcholinesterase that are structurally related to the very potent inhibitor, 1,2,3,4-tetrahydro-9-aminoacridine (THA).
Jan P. Maddox +4 more
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1987
An account is given of the purification of the ethylene binding protein from developing cotyeldons of Phaseolus vulgaris. A correlation has been demonstrated between ethylene binding and sensitivity to the hormone in epicotyls of Pisum sativum. As this tissue also metabolises ethylene, this system could provide evidence for the hypothesis that ethylene
R. A. N. Williams +4 more
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An account is given of the purification of the ethylene binding protein from developing cotyeldons of Phaseolus vulgaris. A correlation has been demonstrated between ethylene binding and sensitivity to the hormone in epicotyls of Pisum sativum. As this tissue also metabolises ethylene, this system could provide evidence for the hypothesis that ethylene
R. A. N. Williams +4 more
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The taxonomy of binding sites in proteins
Molecular and Cellular Biochemistry, 1978Conservation of polypeptide fold and mode of ligand binding is frequently found within proteins of related function. Examples illustrating this phenomenon are taken from NAD linked enzymes, nucleotide binding proteins, polysaccharide binding proteins, heme binding proteins and enzymes with essential Fe--S complexes or zinc atoms.
Michael G. Rossmann, Patrick Argos
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Localization of the Chaperone Binding-Site
Biochemical and Biophysical Research Communications, 1993The hypothesis derived from models of the multi-oligomeric chaperone complex suggests that partially denatured proteins bind in a central cavity in the aggregate. To test this hypothesis, the molecular chaperone, alpha crystallin, was bound to partially denatured forms of gamma crystallin, and the binding site was visualized by immunogold localization.
Daniel L. Boyle +2 more
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