Results 371 to 380 of about 8,121,841 (424)
Some of the next articles are maybe not open access.
Mitochondrial Binding Sites for Triiodothyronine
Endocrinology, 1978Metabolic effects upon rat liver mitochondria have been observed by others within 2 min of injection of massive amounts of L-T4. Reported here is the subcellular distribution of 2--5 ng high specific activity [125I]L-T3 2 min after ip injection with and without a loading dose of 30 micrograms unlabeled T3.
Roger L. Greif, Denise A. Sloane
openaire +3 more sources
Order out of chaos: assembly of ligand binding sites in heparan sulfate.
Annual Review of Biochemistry, 2002Virtually every cell type in metazoan organisms produces heparan sulfate. These complex polysaccharides provide docking sites for numerous protein ligands and receptors involved in diverse biological processes, including growth control, signal ...
J. Esko, S. Selleck
semanticscholar +1 more source
A Binding Site for Chlorambucil on Metallothionein
Biochemistry, 1996It is of interest to test the hypothesis that induced metallothionein (MT) acts in acquired drug resistance by covalent sequestration. In this study MT was incubated in vitro with chlorambucil (CHB) under conditions where only 1:1 covalent adducts were formed.
Joseph Zaia +6 more
openaire +3 more sources
Metal-binding sites in proteins
Current Opinion in Biotechnology, 1991A dramatic increase in the number of solved metalloprotein structures and recent breakthroughs in structural analysis have provided a sufficiently detailed understanding of the structural chemistry of some metal-binding sites to allow successful design.
Elizabeth D. Getzoff +2 more
openaire +3 more sources
Database Searches for Binding Sites
Science, 2000In their Report “Identification of a coordinate regulator of interleukins 4, 13, and 5 by cross-species sequence comparisons” (7 Apr., p. [136][1]), G. G. Loots and colleagues identify conserved noncoding sequences (CNSs) in orthologous regions of the interleukin (IL)-4/13/5 locus of ...
K, Murphy +3 more
openaire +3 more sources
Peripheral benzodiazepine binding sites
Pharmacology & Therapeutics, 1989Article de synthese sur les sites de fixation peripheriques des benzodiazepines: distribution, fixation biologique, action au niveau du systeme nerveux central, regulation par le GABA et le stress, regulation endocrine, relation avec les canaux calcium, autres ligands, role ...
Markku Räty, Veijo Saano, Lembit Rägo
openaire +3 more sources
Substrate-binding sites in acetylcholinesterase
Trends in Pharmacological Sciences, 1991Acetylcholinesterase is among the most efficient enzymes known. In order to provide an explanation for its catalytic and regulatory mechanisms, including the high turnover rate, the specific amino acid residues involved in substrate binding and hydrolysis need to be identified.
Christoph Weise +2 more
openaire +3 more sources
A citrate-binding site in calmodulin
Journal of Molecular Recognition, 1998Calmodulin (CaM) is a major Ca2+ messenger which, upon Ca2+ activation, binds and activates a number of target enzymes involved in crucial cellular processes. The dependence on Ca2+ ion concentration suggests that CaM activation may be modulated by low-affinity Ca2+ chelators.
Karol A. Muszkat +3 more
openaire +3 more sources
Binding sites for calcium on tubulin
Biochemistry, 1977Calcium ions can inhibit the in vitro assembly of microtubules and, therefore, may play a role in the regulation of microtubule formation in vivo. In order to test the validity of this hypothesis; the interaction between calcium and pruified brain microtubular protein has been investigated by standard binding assays.
openaire +2 more sources
Hydrophobic binding site in acetylcholinesterase
Journal of Medicinal Chemistry, 1975The dissociation constants have been determined and compared for a series of reversible, noncovalent inhibitors of eel acetylcholinesterase that are structurally related to the very potent inhibitor, 1,2,3,4-tetrahydro-9-aminoacridine (THA).
Jan P. Maddox +4 more
openaire +3 more sources