Results 181 to 190 of about 1,435,643 (295)

Cross‐Cohort Evidence Links KCNJ6 rs702859 to Impulsive–Compulsive Phenotypes in Parkinson's Disease

Movement Disorders, EarlyView.
Abstract Background Impulse control disorders (ICDs) and related compulsive behaviors (CBs) are frequent non‐motor complications of Parkinson's disease (PD) with a probable genetic contribution. Objective To investigate whether genetic variants involved in reward and punishment processing are associated with impulsive–compulsive phenotypes in PD ...
Sergio García‐Díaz, Juan Francisco Martín‐Rodríguez, Laura Muñoz‐Delgado, Rafael Díaz‐Belloso, Silvia Jesús, María Teresa Periñán, Miguel Martín‐Bórnez, Ana M. Castellano‐Guerrero, Elena Ojeda‐Lepe, Daniel Macías‐García, Astrid Adarmes‐Gómez, Dolores Buiza‐Rueda, Marta Bonilla‐Toribio, Elena Iglesias‐Camacho, Manuela San‐Eufrasio, Cristina Pérez‐Calvo, Rocío Pineda‐Sánchez, Francisco Javier Gómez‐Campos, Antonio Luque‐Ambrosiani, Fátima Carrillo‐García, Pilar Gómez‐Garre, Pablo Mir   +21 more
wiley   +1 more source

Understanding vulnerabilities and resilience in binge eating disorder among female population and transgender individuals across the lifespan: a narrative review. [PDF]

Eat Weight Disord
Madini N, Breda C, El Masri D, Rizzo CR, Lanati S, Stanford FC, Vincenti A, Cena H, De Giuseppe R.   +8 more
europepmc   +1 more source

Effects of Orbitofrontal Cortex tDCS on Cognitive Control in Individuals With Obesity: A Randomized Sham‐Controlled Trial

Obesity, EarlyView.
ABSTRACT Objective Neurocognitive traits can drive obesity‐related eating behaviors. The orbitofrontal cortex (OFC) integrates reward and sensory information to guide food‐related decision‐making. Here, we build on prior data in individuals without obesity demonstrating that transcranial direct current stimulation (tDCS) of the OFC improves cognitive ...
Jessica Ruffolo, Alexander McGirr, Stephanie L. Borgland   +2 more
wiley   +1 more source

Naltrexone/bupropion for binge-eating disorder: A human laboratory investigation of mechanisms. [PDF]

Drug Alcohol Depend Rep
McKee SA, Lydecker JA, Pittman B, Jastreboff AM, DiLeone RJ, Lavery M, Grilo CM.   +6 more
europepmc   +1 more source

Suppression of PKM2 by Leonurine Attenuates Alcoholic Hepatitis Through Regulating Glycolytic Reprogramming

Phytotherapy Research, EarlyView.
Leonurine inhibits PKM2 to remodel hepatocyte glycolysis, thereby alleviating liver injury in alcoholic hepatitis. ABSTRACT Alcoholic hepatitis (AH) is a liver disease caused by long‐term heavy drinking. In the early stages, it usually manifests as fatty liver, which can then develop into liver fibrosis and cirrhosis.
Xuan‐Xuan Zhang, Gao‐Feng Pan, Hong Fang, Xiao‐Peng Liu, Jing Sun, Ji‐Xiang Chen, Xin Fan, Jia‐Hao Feng   +7 more
wiley   +1 more source

Toll‐Like Receptor 4 Signaling in Natural N‐Acylethanolamines and Derivative NAE‐Like Compounds: Mechanisms and Implications for Neuroimmune and Inflammatory Processes in a Systematic Search Approach

Phytotherapy Research, EarlyView.
ABSTRACT N‐acylethanolamines (NAEs) are endogenous fatty acid amides structurally related to the endocannabinoid anandamide and function as bioactive lipid mediators with broad regulatory roles in inflammation and neuroinflammation. Among pattern‐recognition receptors, Toll‐like receptor 4 (TLR4) occupies a central position in innate immune ...
Damiana Scuteri, Francesca Guida, Giacinto Bagetta, Sabatino Maione, Maria Tiziana Corasaniti, Morena Zusso   +5 more
wiley   +1 more source

Implementing Supported Digital Enhanced Cognitive Behavior Therapy for Binge Eating Disorder in Routine Care: Mixed Methods Service Evaluation. [PDF]

J Med Internet Res
Osborne EL, Powell J, Brown C, Cresswell-Nash G, Debrou L, Defever E, Greenwood S, Horton J, Hunter E, Lees A, Moore M, Newell C, Randell B, Rosten C, Shaw N, Yao V, Murphy R.   +16 more
europepmc   +1 more source

Polyphyllin I Alleviates Alcoholic Liver Disease via Modulation of the Phosphodiesterase 6D–Cyclic Guanosine Monophosphate–Protein Kinase G Axis

Phytotherapy Research, EarlyView.
ABSTRACT Alcoholic liver disease (ALD) is a multifaceted disorder in which oxidative injury, iron‐dependent ferroptosis, steatosis, and inflammation are closely intertwined. Consequently, therapeutic strategies targeting a single pathway often produce limited clinical benefits.
Hongyan Feng, Xuelian Yuan, Yawen Xie, Zhenni Xia, Zhaohui Guo, Xuesong Liu, Rong Li, Wenliang Wang   +7 more
wiley   +1 more source

Binge Eating Disorder in Bipolar I Disorder: Prevalence, Childhood Trauma, and Clinical Correlates. [PDF]

Noro Psikiyatr Ars
Karabıyık B, Onur ÖŞ, Karamustafalıoğlu N.   +2 more
europepmc   +1 more source

Play Hard, Work (Too) Hard: The Impact of Gamification on Work Addiction, Burnout, and Turnover Intention

Human Resource Management Journal, EarlyView.
ABSTRACT Gamification is being increasingly implemented within human resource management by organizations to incentivize employees to remain engaged with their work. However, despite nascent empirical evidence on the potential drawbacks of gamification for employees, our understanding of these consequences remains limited. Our study aims to explore the
Francis Maisonneuve, Antoine Bujold, Xavier Parent‐Rocheleau   +2 more
wiley   +1 more source